Aliases for ZNF433 Gene

Aliases for ZNF433 Gene

  • Zinc Finger Protein 433 2 3 4 5

External Ids for ZNF433 Gene

Previous GeneCards Identifiers for ZNF433 Gene

  • GC19M011970
  • GC19M011986
  • GC19M011698
  • GC19M012125

Summaries for ZNF433 Gene

GeneCards Summary for ZNF433 Gene

ZNF433 (Zinc Finger Protein 433) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF700.

UniProtKB/Swiss-Prot Summary for ZNF433 Gene

Additional gene information for ZNF433 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF433 Gene

Genomics for ZNF433 Gene

GeneHancer (GH) Regulatory Elements for ZNF433 Gene

Promoters and enhancers for ZNF433 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF433 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF433 gene promoter:
  • FOXD3

Genomic Locations for ZNF433 Gene

Genomic Locations for ZNF433 Gene
21,025 bases
Minus strand
21,025 bases
Minus strand

Genomic View for ZNF433 Gene

Genes around ZNF433 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF433 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF433 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF433 Gene

Proteins for ZNF433 Gene

  • Protein details for ZNF433 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 433
    Protein Accession:
    Secondary Accessions:
    • Q86VX3

    Protein attributes for ZNF433 Gene

    673 amino acids
    Molecular mass:
    77243 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF433 Gene


neXtProt entry for ZNF433 Gene

Post-translational modifications for ZNF433 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF433 Gene

Domains & Families for ZNF433 Gene

Gene Families for ZNF433 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transcription factors

Protein Domains for ZNF433 Gene

Suggested Antigen Peptide Sequences for ZNF433 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 433 (ZN433_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF433: view

Function for ZNF433 Gene

Molecular function for ZNF433 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF433 Gene

Gene Ontology (GO) - Molecular Function for ZNF433 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF433: view
genes like me logo Genes that share phenotypes with ZNF433: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF433 Gene

Localization for ZNF433 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF433 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF433 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF433 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF433: view

Pathways & Interactions for ZNF433 Gene

genes like me logo Genes that share pathways with ZNF433: view

Pathways by source for ZNF433 Gene

2 Reactome pathways for ZNF433 Gene
1 KEGG pathway for ZNF433 Gene

Gene Ontology (GO) - Biological Process for ZNF433 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF433: view

No data available for SIGNOR curated interactions for ZNF433 Gene

Drugs & Compounds for ZNF433 Gene

No Compound Related Data Available

Transcripts for ZNF433 Gene

mRNA/cDNA for ZNF433 Gene

(7) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF433 Gene

No ASD Table

Relevant External Links for ZNF433 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF433 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF433 Gene

mRNA differential expression in normal tissues according to GTEx for ZNF433 Gene

This gene is overexpressed in Testis (x6.0).

Protein differential expression in normal tissues from HIPED for ZNF433 Gene

This gene is overexpressed in Plasma (60.9) and Retina (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF433 Gene

Protein tissue co-expression partners for ZNF433 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF433 Gene:


SOURCE GeneReport for Unigene cluster for ZNF433 Gene:

genes like me logo Genes that share expression patterns with ZNF433: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF433 Gene

Orthologs for ZNF433 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF433 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF433 33 32
  • 99.6 (n)
(Mus musculus)
Mammalia LOC102635315 32
  • 68.22 (n)
Zfp433 17
(Bos Taurus)
Mammalia -- 33
  • 51 (a)
Species where no ortholog for ZNF433 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF433 Gene

Gene Tree for ZNF433 (if available)
Gene Tree for ZNF433 (if available)
Evolutionary constrained regions (ECRs) for ZNF433: view image

Paralogs for ZNF433 Gene

(472) SIMAP similar genes for ZNF433 Gene using alignment to 9 proteins:

  • ZN433_HUMAN
  • F8VP42_HUMAN
  • F8VU36_HUMAN
  • F8W0C9_HUMAN
  • F8W652_HUMAN Pseudogenes for ZNF433 Gene

genes like me logo Genes that share paralogs with ZNF433: view

Variants for ZNF433 Gene

Sequence variations from dbSNP and Humsavar for ZNF433 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000146377 -- 12,017,195(-) TTTTTTTT/TTTTTTT/TTTTTTTTT intron_variant
rs1000341634 -- 12,029,911(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000348481 -- 12,035,664(-) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000471168 -- 12,031,364(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000754956 -- 12,034,622(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF433 Gene

Variant ID Type Subtype PubMed ID
esv3415797 CNV insertion 20981092
nsv525966 CNV gain 19592680
nsv578619 CNV loss 21841781
nsv978771 CNV duplication 23825009

Variation tolerance for ZNF433 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.76; 47.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF433 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF433 Gene

Disorders for ZNF433 Gene

Additional Disease Information for ZNF433

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF433 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF433 Gene

Publications for ZNF433 Gene

  1. Evidence for VAV2 and ZNF433 as susceptibility genes for multiple sclerosis. (PMID: 20598377) Nischwitz S … Weber F (Journal of neuroimmunology 2010) 3 43 56
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 56

Products for ZNF433 Gene

Sources for ZNF433 Gene