Aliases for ZNF432 Gene

Aliases for ZNF432 Gene

  • Zinc Finger Protein 432 2 3 4 5
  • KIAA0798 2 4
  • ZNF432 5

External Ids for ZNF432 Gene

Previous GeneCards Identifiers for ZNF432 Gene

  • GC19M057172
  • GC19M057226
  • GC19M057190
  • GC19M057216
  • GC19M052467
  • GC19M052536

Summaries for ZNF432 Gene

GeneCards Summary for ZNF432 Gene

ZNF432 (Zinc Finger Protein 432) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF615.

UniProtKB/Swiss-Prot Summary for ZNF432 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF432 Gene

Genomics for ZNF432 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF432 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF432 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF432

Top Transcription factor binding sites by QIAGEN in the ZNF432 gene promoter:
  • Nkx3-1
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Nkx3-1 v3
  • Nkx3-1 v4

Genomic Locations for ZNF432 Gene

Latest Assembly
64,361 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
17,461 bases
Minus strand

(GRCh37/hg19 by Ensembl)
64,360 bases
Minus strand

Genomic View for ZNF432 Gene

Genes around ZNF432 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF432 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF432 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF432 Gene

Proteins for ZNF432 Gene

  • Protein details for ZNF432 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 432
    Protein Accession:

    Protein attributes for ZNF432 Gene

    652 amino acids
    Molecular mass:
    74836 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA34518.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF432 Gene

Post-translational modifications for ZNF432 Gene

  • Glycosylation at Asn140
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ZN432_HUMAN (2092)

No data available for DME Specific Peptides for ZNF432 Gene

Domains & Families for ZNF432 Gene

Gene Families for ZNF432 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF432 Gene

  • KRAB box

Suggested Antigen Peptide Sequences for ZNF432 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 432 (ZN432_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF432: view

Function for ZNF432 Gene

Molecular function for ZNF432 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF432 Gene

Gene Ontology (GO) - Molecular Function for ZNF432 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with ZNF432: view
genes like me logo Genes that share phenotypes with ZNF432: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF432

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF432 Gene

Localization for ZNF432 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF432 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF432 gene
Compartment Confidence
nucleus 4
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF432 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF432: view

Pathways & Interactions for ZNF432 Gene

genes like me logo Genes that share pathways with ZNF432: view

Pathways by source for ZNF432 Gene

2 Reactome pathways for ZNF432 Gene
1 KEGG pathway for ZNF432 Gene

Gene Ontology (GO) - Biological Process for ZNF432 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF432: view

No data available for SIGNOR curated interactions for ZNF432 Gene

Drugs & Compounds for ZNF432 Gene

No Compound Related Data Available

Transcripts for ZNF432 Gene

mRNA/cDNA for ZNF432 Gene

5 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF432

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF432 Gene

No ASD Table

Relevant External Links for ZNF432 Gene

GeneLoc Exon Structure for

Expression for ZNF432 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF432 Gene

Protein differential expression in normal tissues from HIPED for ZNF432 Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF432 Gene

Protein tissue co-expression partners for ZNF432 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF432

SOURCE GeneReport for Unigene cluster for ZNF432 Gene:


Evidence on tissue expression from TISSUES for ZNF432 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF432: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF432 Gene

Orthologs for ZNF432 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF432 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF432 30 31
  • 99.54 (n)
(Canis familiaris)
Mammalia ZNF432 30
  • 87.3 (n)
(Bos Taurus)
Mammalia ZNF432 30
  • 85.43 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 47 (a)
-- 31
  • 44 (a)
(Anolis carolinensis)
Reptilia ZNF432 31
  • 41 (a)
(Danio rerio)
Actinopterygii si:ch211-202h22.10 30
  • 53.58 (n)
Species where no ortholog for ZNF432 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF432 Gene

Gene Tree for ZNF432 (if available)
Gene Tree for ZNF432 (if available)
Evolutionary constrained regions (ECRs) for ZNF432: view image

Paralogs for ZNF432 Gene

Paralogs for ZNF432 Gene

(449) SIMAP similar genes for ZNF432 Gene using alignment to 5 proteins:

  • ZN432_HUMAN
  • M0QZ71_HUMAN
  • M0R0E2_HUMAN
  • M0R0H8_HUMAN
  • M0R258_HUMAN Pseudogenes for ZNF432 Gene

genes like me logo Genes that share paralogs with ZNF432: view

Variants for ZNF432 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF432 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs117633649 Benign: not provided 52,034,081(-) C/T
NM_014650.4(ZNF432):c.1598G>A (p.Arg533Gln)
rs755035378 A breast cancer sample p.Cys490Tyr
VAR_035577 A breast cancer sample p.Leu416Val

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF432 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNF432 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3626n100 CNV gain 25217958
dgv425n27 CNV gain 19166990
dgv6523n54 CNV gain 21841781
esv2758767 CNV gain+loss 17122850
esv3644684 CNV gain 21293372
nsv1140251 OTHER inversion 24896259
nsv833872 CNV loss 17160897

Variation tolerance for ZNF432 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.53; 82.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF432 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF432 Gene

Disorders for ZNF432 Gene

Additional Disease Information for ZNF432

Genetic Association Database
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for ZNF432 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF432 Gene

Publications for ZNF432 Gene

  1. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X … Desiderio DM (Analytical biochemistry 2006) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3

Products for ZNF432 Gene

Sources for ZNF432 Gene