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Aliases for ZNF432 Gene

Aliases for ZNF432 Gene

  • Zinc Finger Protein 432 2 3 5
  • KIAA0798 4

External Ids for ZNF432 Gene

Previous GeneCards Identifiers for ZNF432 Gene

  • GC19M057172
  • GC19M057226
  • GC19M057190
  • GC19M057216
  • GC19M052467
  • GC19M052536

Summaries for ZNF432 Gene

GeneCards Summary for ZNF432 Gene

ZNF432 (Zinc Finger Protein 432) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF33B.

UniProtKB/Swiss-Prot for ZNF432 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF432 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF432 Gene

Genomics for ZNF432 Gene

GeneHancer (GH) Regulatory Elements for ZNF432 Gene

Promoters and enhancers for ZNF432 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I052047 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 566 +46.8 46837 2.2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B E2F8 ZNF143 ZNF432 ENSG00000275055 ZNF841 ZNF614
GH19I052093 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 556.1 +0.6 599 2.7 ATF1 ARID4B SIN3A ZNF48 POLR2B GLIS2 E2F8 KLF13 SP3 NCOA1 ZNF841 ZNF432 GC19M052098 ZNF613 ZNF137P ENSG00000268970 ZNF701 ZNF611 ZNF28 ZNF578
GH19I051393 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE 58.1 +700.7 700691 2.8 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B SIN3A IRF4 YY1 POLR2B ENSG00000268889 LOC105372446 ZNF841 ZNF766 ZNF577 ZNF616 ZNF175 ZNF836 ZNF432 ZNF614
GH19I051687 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 40.5 +405.2 405247 6.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZBTB7B E2F8 ZNF207 ZNF143 ZNF137P ZNF808 ZNF841 ZNF616 ZNF766 ZNF577 ENSG00000268970 ZNF836 ENSG00000269825 ZNF175
GH19I052026 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 16 +67.8 67825 3 HDGF PKNOX1 FOXA2 SMAD1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF614 ZNF841 ZNF613 ZNF137P ZNF432 ENSG00000269483 ENSG00000268970 ZNF701 ZNF611 ZNF528
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF432 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF432 gene promoter:

Genomic Locations for ZNF432 Gene

Genomic Locations for ZNF432 Gene
chr19:52,031,378-52,095,738
(GRCh38/hg38)
Size:
64,361 bases
Orientation:
Minus strand
chr19:52,534,632-52,598,991
(GRCh37/hg19)

Genomic View for ZNF432 Gene

Genes around ZNF432 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF432 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF432 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF432 Gene

Proteins for ZNF432 Gene

  • Protein details for ZNF432 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94892-ZN432_HUMAN
    Recommended name:
    Zinc finger protein 432
    Protein Accession:
    O94892

    Protein attributes for ZNF432 Gene

    Size:
    652 amino acids
    Molecular mass:
    74836 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA34518.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF432 Gene

Post-translational modifications for ZNF432 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF432 Gene

No data available for DME Specific Peptides for ZNF432 Gene

Domains & Families for ZNF432 Gene

Gene Families for ZNF432 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF432 Gene

Suggested Antigen Peptide Sequences for ZNF432 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O94892

UniProtKB/Swiss-Prot:

ZN432_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF432: view

Function for ZNF432 Gene

Molecular function for ZNF432 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF432 Gene

Gene Ontology (GO) - Molecular Function for ZNF432 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF432: view
genes like me logo Genes that share phenotypes with ZNF432: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF432 Gene

Localization for ZNF432 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF432 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF432 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF432 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ZNF432: view

Pathways & Interactions for ZNF432 Gene

SuperPathways for ZNF432 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF432: view

Pathways by source for ZNF432 Gene

2 Reactome pathways for ZNF432 Gene

Gene Ontology (GO) - Biological Process for ZNF432 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF432: view

No data available for SIGNOR curated interactions for ZNF432 Gene

Drugs & Compounds for ZNF432 Gene

No Compound Related Data Available

Transcripts for ZNF432 Gene

Unigene Clusters for ZNF432 Gene

Zinc finger protein 432:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF432 Gene

No ASD Table

Relevant External Links for ZNF432 Gene

GeneLoc Exon Structure for
ZNF432
ECgene alternative splicing isoforms for
ZNF432

Expression for ZNF432 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF432 Gene

Protein differential expression in normal tissues from HIPED for ZNF432 Gene

This gene is overexpressed in Islet of Langerhans (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF432 Gene



Protein tissue co-expression partners for ZNF432 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF432 Gene:

ZNF432

SOURCE GeneReport for Unigene cluster for ZNF432 Gene:

Hs.655934

Evidence on tissue expression from TISSUES for ZNF432 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with ZNF432: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF432 Gene

Orthologs for ZNF432 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF432 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF432 33 34
  • 99.54 (n)
dog
(Canis familiaris)
Mammalia ZNF432 33
  • 87.3 (n)
cow
(Bos Taurus)
Mammalia ZNF432 33
  • 85.43 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 47 (a)
OneToMany
-- 34
  • 44 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia ZNF432 34
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-202h22.10 33
  • 53.58 (n)
Species where no ortholog for ZNF432 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF432 Gene

ENSEMBL:
Gene Tree for ZNF432 (if available)
TreeFam:
Gene Tree for ZNF432 (if available)

Paralogs for ZNF432 Gene

(449) SIMAP similar genes for ZNF432 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNF432 Gene

genes like me logo Genes that share paralogs with ZNF432: view

Variants for ZNF432 Gene

Sequence variations from dbSNP and Humsavar for ZNF432 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs755035378 A breast cancer sample 52,034,210(-) C/T coding_sequence_variant, missense_variant
VAR_035577 A breast cancer sample p.Leu416Val
rs1000031777 -- 52,049,378(-) T/C upstream_transcript_variant
rs1000040430 -- 52,042,653(-) T/A intron_variant
rs1000083441 -- 52,049,191(-) G/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF432 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3626n100 CNV gain 25217958
dgv425n27 CNV gain 19166990
dgv6523n54 CNV gain 21841781
esv2758767 CNV gain+loss 17122850
esv3644684 CNV gain 21293372
nsv1140251 OTHER inversion 24896259
nsv833872 CNV loss 17160897

Variation tolerance for ZNF432 Gene

Residual Variation Intolerance Score: 28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.53; 82.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF432 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF432

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF432 Gene

Disorders for ZNF432 Gene

Additional Disease Information for ZNF432

No disorders were found for ZNF432 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF432 Gene

Publications for ZNF432 Gene

  1. Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. (PMID: 16777052) Zhan X … Desiderio DM (Analytical biochemistry 2006) 3 4 22 58
  2. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 9872452) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics. (PMID: 24280104) Wu AC … Tantisira K (The Journal of allergy and clinical immunology 2014) 3 58

Products for ZNF432 Gene

Sources for ZNF432 Gene

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