External Ids for ZNF431 Gene
Previous GeneCards Identifiers for ZNF431 Gene
This gene encodes a member of the Krueppel C2H2-type zinc-finger family of proteins. The encoded protein may negatively regulate transcription of target genes, including the hedgehog signaling pathway receptor patched 1, by interacting with histone deacetylases. Mutations in this gene may be associated with non-syndromic facial clefting in human patients. [provided by RefSeq, Jul 2016]
GeneCards Summary for ZNF431 Gene
ZNF431 (Zinc Finger Protein 431) is a Protein Coding gene. Diseases associated with ZNF431 include Cleft Palate, Isolated. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and core promoter sequence-specific DNA binding. An important paralog of this gene is ZNF430.
UniProtKB/Swiss-Prot Summary for ZNF431 Gene
Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity).