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Aliases for ZNF430 Gene

Aliases for ZNF430 Gene

  • Zinc Finger Protein 430 2 3 3 5

External Ids for ZNF430 Gene

Previous GeneCards Identifiers for ZNF430 Gene

  • GC19P020979
  • GC19P021203
  • GC19P020694

Summaries for ZNF430 Gene

GeneCards Summary for ZNF430 Gene

ZNF430 (Zinc Finger Protein 430) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF431.

UniProtKB/Swiss-Prot for ZNF430 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF430 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF430 Gene

Genomics for ZNF430 Gene

GeneHancer (GH) Regulatory Elements for ZNF430 Gene

Promoters and enhancers for ZNF430 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J021019 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 650.7 +1.7 1656 4.6 HDGF PKNOX1 ATF1 SMAD1 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF714 ZNF430 ZNF100 LOC641367 ZNF90 BNIP3P26 RPL7AP10 ZNF66 ZNF431 ZNF486
GH19J021504 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 2.3 +485.4 485415 2.6 PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 ZNF48 YY1 POLR2B ZNF766 ZNF429 ENSG00000268555 ZNF708 ZNF493 ZNF100 ZNF430 PIR57057 PIR58149
GH19J021314 Enhancer 0.7 FANTOM5 ENCODE 2 +294.3 294348 1.3 JUND CUX1 ZNF708 ZNF429 ENSG00000213976 ZNF493 ZNF100 ZNF430 BNIP3P25 GC19M022495
GH19J021495 Enhancer 0.3 FANTOM5 1.4 +474.9 474875 0.2 MITF ZNF429 ZNF100 ZNF430 LINC00664
GH19J021027 Enhancer 0.9 Ensembl ENCODE 0.4 +7.8 7848 1.4 HDGF PKNOX1 BATF IRF4 EGR1 EED ATF7 ZSCAN29 BCLAF1 IKZF2 ZNF714 ENSG00000271598 ZNF430 VN1R80P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF430 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF430 gene promoter:
  • RFX1
  • Pax-5
  • USF-1
  • USF-1:USF-2
  • USF1
  • USF2
  • NF-YB
  • NF-YA
  • NF-Y
  • CP1A

Genomic Locations for ZNF430 Gene

Genomic Locations for ZNF430 Gene
39,436 bases
Plus strand
39,431 bases
Plus strand

Genomic View for ZNF430 Gene

Genes around ZNF430 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF430 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF430 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF430 Gene

Proteins for ZNF430 Gene

  • Protein details for ZNF430 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 430
    Protein Accession:
    Secondary Accessions:
    • Q86V70

    Protein attributes for ZNF430 Gene

    570 amino acids
    Molecular mass:
    66319 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14656.1; Type=Frameshift; Positions=293; Evidence={ECO:0000305};

neXtProt entry for ZNF430 Gene

Post-translational modifications for ZNF430 Gene

  • Ubiquitination at isoforms=188
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF430 Gene

No data available for DME Specific Peptides for ZNF430 Gene

Domains & Families for ZNF430 Gene

Gene Families for ZNF430 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF430 Gene

Suggested Antigen Peptide Sequences for ZNF430 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF430: view

Function for ZNF430 Gene

Molecular function for ZNF430 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF430 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF430: view
genes like me logo Genes that share phenotypes with ZNF430: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF430 Gene

Localization for ZNF430 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF430 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF430 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF430 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF430: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF430 Gene

Pathways & Interactions for ZNF430 Gene

SuperPathways for ZNF430 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF430: view

Pathways by source for ZNF430 Gene

2 Reactome pathways for ZNF430 Gene

Gene Ontology (GO) - Biological Process for ZNF430 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0021762 substantia nigra development HEP 22926577
genes like me logo Genes that share ontologies with ZNF430: view

No data available for SIGNOR curated interactions for ZNF430 Gene

Drugs & Compounds for ZNF430 Gene

No Compound Related Data Available

Transcripts for ZNF430 Gene

mRNA/cDNA for ZNF430 Gene

Unigene Clusters for ZNF430 Gene

Zinc finger protein 430:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF430 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b
SP3: - - -

Relevant External Links for ZNF430 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF430 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF430 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF430 Gene

Protein tissue co-expression partners for ZNF430 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF430 Gene:


SOURCE GeneReport for Unigene cluster for ZNF430 Gene:

genes like me logo Genes that share expression patterns with ZNF430: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF430 Gene

Orthologs for ZNF430 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF430 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF430 34 33
  • 99.04 (n)
(Bos Taurus)
Mammalia -- 34
  • 53 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
-- 34
  • 37 (a)
(Mus musculus)
Mammalia Zfp874b 34
  • 49 (a)
(Canis familiaris)
Mammalia -- 34
  • 38 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 52 (a)
-- 34
  • 39 (a)
-- 34
  • 39 (a)
-- 34
  • 33 (a)
-- 34
  • 31 (a)
-- 34
  • 31 (a)
-- 34
  • 30 (a)
-- 34
  • 29 (a)
Species where no ortholog for ZNF430 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF430 Gene

Gene Tree for ZNF430 (if available)
Gene Tree for ZNF430 (if available)
Evolutionary constrained regions (ECRs) for ZNF430: view image

Paralogs for ZNF430 Gene

(533) SIMAP similar genes for ZNF430 Gene using alignment to 6 proteins:

  • ZN430_HUMAN
  • M0R0L5_HUMAN
  • M0R392_HUMAN
  • Q2NKJ9_HUMAN Pseudogenes for ZNF430 Gene

genes like me logo Genes that share paralogs with ZNF430: view

Variants for ZNF430 Gene

Sequence variations from dbSNP and Humsavar for ZNF430 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000066724 -- 21,026,266(+) G/A/T intron_variant
rs1000106837 -- 21,044,631(+) C/G intron_variant
rs1000114095 -- 21,051,230(+) C/T intron_variant
rs1000159168 -- 21,021,282(+) A/G intron_variant
rs1000193014 -- 21,042,271(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF430 Gene

Variant ID Type Subtype PubMed ID
esv1634993 CNV deletion 17803354
esv2763043 CNV gain 21179565
nsv1061327 CNV gain 25217958
nsv2439 CNV insertion 18451855
nsv458377 CNV gain 19166990
nsv578809 CNV gain 21841781
nsv578949 CNV loss 21841781
nsv960811 CNV duplication 23825009

Variation tolerance for ZNF430 Gene

Residual Variation Intolerance Score: 77.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF430 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF430 Gene

Disorders for ZNF430 Gene

Additional Disease Information for ZNF430

No disorders were found for ZNF430 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF430 Gene

Publications for ZNF430 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis. (PMID: 22926577) Chen S … Liu F (Neurochemical research 2012) 3 58
  5. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 58

Products for ZNF430 Gene

Sources for ZNF430 Gene

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