Aliases for ZNF428 Gene

Aliases for ZNF428 Gene

  • Zinc Finger Protein 428 2 3 4 5
  • Enzyme-Like Protein PIT13 3 4
  • C19orf37 3 4
  • Zfp428 2 3
  • Chromosome 19 Open Reading Frame 37 2
  • MGC51082 2
  • ZNF428 5

External Ids for ZNF428 Gene

Previous HGNC Symbols for ZNF428 Gene

  • C19orf37

Previous GeneCards Identifiers for ZNF428 Gene

  • GC19M048805
  • GC19M044112
  • GC19M040542
  • GC19M044115

Summaries for ZNF428 Gene

GeneCards Summary for ZNF428 Gene

ZNF428 (Zinc Finger Protein 428) is a Protein Coding gene. Diseases associated with ZNF428 include Fibrosarcoma Of Bone.

Additional gene information for ZNF428 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF428 Gene

Genomics for ZNF428 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF428 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF428 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF428

Top Transcription factor binding sites by QIAGEN in the ZNF428 gene promoter:
  • Pax-5
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6

Genomic Locations for ZNF428 Gene

Genomic Locations for ZNF428 Gene
chr19:43,607,224-43,619,629
(GRCh38/hg38)
Size:
12,406 bases
Orientation:
Minus strand
chr19:44,111,371-44,124,026
(GRCh37/hg19)
Size:
12,656 bases
Orientation:
Minus strand

Genomic View for ZNF428 Gene

Genes around ZNF428 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF428 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF428 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF428 Gene

Proteins for ZNF428 Gene

  • Protein details for ZNF428 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B54-ZN428_HUMAN
    Recommended name:
    Zinc finger protein 428
    Protein Accession:
    Q96B54
    Secondary Accessions:
    • O95054
    • Q6X3Y3

    Protein attributes for ZNF428 Gene

    Size:
    188 amino acids
    Molecular mass:
    20481 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC99795.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAP87382.1; Type=Miscellaneous discrepancy; Note=Intron retention at the C-terminus.; Evidence={ECO:0000305};

neXtProt entry for ZNF428 Gene

Post-translational modifications for ZNF428 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF428 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF428 Gene

Domains & Families for ZNF428 Gene

Gene Families for ZNF428 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF428 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF428 Gene

GenScript: Design optimal peptide antigens:
  • Enzyme-like protein PIT13 (ZN428_HUMAN)
genes like me logo Genes that share domains with ZNF428: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF428 Gene

Function for ZNF428 Gene

Phenotypes From GWAS Catalog for ZNF428 Gene

Gene Ontology (GO) - Molecular Function for ZNF428 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF428: view

Phenotypes for ZNF428 Gene

genes like me logo Genes that share phenotypes with ZNF428: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF428

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF428 Gene

Localization for ZNF428 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF428 gene
Compartment Confidence
nucleus 4
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ZNF428 Gene

Pathways & Interactions for ZNF428 Gene

PathCards logo

SuperPathways for ZNF428 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF428 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF428 Gene

Drugs & Compounds for ZNF428 Gene

No Compound Related Data Available

Transcripts for ZNF428 Gene

mRNA/cDNA for ZNF428 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF428

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF428 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4
SP1: - -
SP2: -
SP3:

Relevant External Links for ZNF428 Gene

GeneLoc Exon Structure for
ZNF428

Expression for ZNF428 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF428 Gene

Protein differential expression in normal tissues from HIPED for ZNF428 Gene

This gene is overexpressed in Adrenal (45.5) and Fetal Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF428 Gene



Protein tissue co-expression partners for ZNF428 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF428

SOURCE GeneReport for Unigene cluster for ZNF428 Gene:

Hs.99093
genes like me logo Genes that share expression patterns with ZNF428: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF428 Gene

Orthologs for ZNF428 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF428 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF428 30 31
  • 99.65 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF428 30 31
  • 87.94 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF428 30 31
  • 85.99 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp428 30 17 31
  • 83.43 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp428 30
  • 82.95 (n)
Oppossum
(Monodelphis domestica)
Mammalia ZNF428 31
  • 69 (a)
OneToOne
Species where no ortholog for ZNF428 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF428 Gene

ENSEMBL:
Gene Tree for ZNF428 (if available)
TreeFam:
Gene Tree for ZNF428 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF428: view image

Paralogs for ZNF428 Gene

(1) SIMAP similar genes for ZNF428 Gene using alignment to 3 proteins:

  • ZN428_HUMAN
  • I6L9C8_HUMAN
  • M0QXZ5_HUMAN
genes like me logo Genes that share paralogs with ZNF428: view

No data available for Paralogs for ZNF428 Gene

Variants for ZNF428 Gene

Additional dbSNP identifiers (rs#s) for ZNF428 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF428 Gene

Variant ID Type Subtype PubMed ID
nsv833839 CNV loss 17160897

Variation tolerance for ZNF428 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF428 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF428

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF428 Gene

Disorders for ZNF428 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF428 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fibrosarcoma of bone
  • malignant fibroxanthoma
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF428: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF428 Gene

Publications for ZNF428 Gene

  1. Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer. (PMID: 29721183) Barreiro-Alonso A … Cerdán ME (Oncotarget 2018) 3
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y … Ge F (Molecular & cellular proteomics : MCP 2013) 3
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods NT … Monteiro AN (Science signaling 2012) 3

Products for ZNF428 Gene

Sources for ZNF428 Gene