Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-protea... See more...

Aliases for ZNF426 Gene

Aliases for ZNF426 Gene

  • Zinc Finger Protein 426 2 3 4 5
  • KSHV RTA Binding Protein 3
  • CTC-543D15.7 3
  • MGC2663 2
  • ZNF426 5
  • K-RBP 3

External Ids for ZNF426 Gene

Previous GeneCards Identifiers for ZNF426 Gene

  • GC19M009861
  • GC19M009483
  • GC19M009499
  • GC19M009638
  • GC19M009219

Summaries for ZNF426 Gene

Entrez Gene Summary for ZNF426 Gene

  • Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for ZNF426 Gene

ZNF426 (Zinc Finger Protein 426) is a Protein Coding gene. Diseases associated with ZNF426 include Kaposi Sarcoma. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF333.

UniProtKB/Swiss-Prot Summary for ZNF426 Gene

Additional gene information for ZNF426 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF426 Gene

Genomics for ZNF426 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF426 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF426 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF426

Top Transcription factor binding sites by QIAGEN in the ZNF426 gene promoter:
  • FOXD3
  • Pbx1a

Genomic Locations for ZNF426 Gene

Genomic Locations for ZNF426 Gene
chr19:9,523,223-9,538,865
(GRCh38/hg38)
Size:
15,643 bases
Orientation:
Minus strand
chr19:9,638,667-9,649,303
(GRCh37/hg19)
Size:
10,637 bases
Orientation:
Minus strand

Genomic View for ZNF426 Gene

Genes around ZNF426 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF426 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF426 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF426 Gene

Proteins for ZNF426 Gene

  • Protein details for ZNF426 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BUY5-ZN426_HUMAN
    Recommended name:
    Zinc finger protein 426
    Protein Accession:
    Q9BUY5
    Secondary Accessions:
    • B3KTL2

    Protein attributes for ZNF426 Gene

    Size:
    554 amino acids
    Molecular mass:
    63106 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF426 Gene

Post-translational modifications for ZNF426 Gene

  • Ubiquitination at Lys204
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF426 Gene

Domains & Families for ZNF426 Gene

Gene Families for ZNF426 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF426 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF426 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 426 (ZN426_HUMAN)
genes like me logo Genes that share domains with ZNF426: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF426 Gene

Function for ZNF426 Gene

Molecular function for ZNF426 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF426 Gene

Gene Ontology (GO) - Molecular Function for ZNF426 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 23414517
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF426: view
genes like me logo Genes that share phenotypes with ZNF426: view

Animal Model Products

CRISPR Products

miRNA for ZNF426 Gene

miRTarBase miRNAs that target ZNF426

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF426

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF426 Gene

Localization for ZNF426 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF426 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF426 gene
Compartment Confidence
nucleus 4
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF426 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF426: view

Pathways & Interactions for ZNF426 Gene

genes like me logo Genes that share pathways with ZNF426: view

Pathways by source for ZNF426 Gene

2 Reactome pathways for ZNF426 Gene
1 KEGG pathway for ZNF426 Gene

Gene Ontology (GO) - Biological Process for ZNF426 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF426: view

No data available for SIGNOR curated interactions for ZNF426 Gene

Drugs & Compounds for ZNF426 Gene

No Compound Related Data Available

Transcripts for ZNF426 Gene

mRNA/cDNA for ZNF426 Gene

4 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF426

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF426 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2:

Relevant External Links for ZNF426 Gene

GeneLoc Exon Structure for
ZNF426

Expression for ZNF426 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF426 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF426 Gene

This gene is overexpressed in Esophagus - Mucosa (x4.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF426 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF426

SOURCE GeneReport for Unigene cluster for ZNF426 Gene:

Hs.594011

Evidence on tissue expression from TISSUES for ZNF426 Gene

  • Skin(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF426: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF426 Gene

Orthologs for ZNF426 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF426 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF426 30 31
  • 99.52 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp426 30 17 31
  • 81.29 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp426 30
  • 80.87 (n)
Dog
(Canis familiaris)
Mammalia -- 31
  • 52 (a)
OneToMany
Cow
(Bos Taurus)
Mammalia -- 31
  • 34 (a)
OneToMany
Species where no ortholog for ZNF426 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF426 Gene

ENSEMBL:
Gene Tree for ZNF426 (if available)
TreeFam:
Gene Tree for ZNF426 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF426: view image

Paralogs for ZNF426 Gene

(531) SIMAP similar genes for ZNF426 Gene using alignment to 3 proteins:

  • ZN426_HUMAN
  • K7EME3_HUMAN
  • K7ER43_HUMAN

Pseudogenes.org Pseudogenes for ZNF426 Gene

genes like me logo Genes that share paralogs with ZNF426: view

Variants for ZNF426 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF426 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs10420644 - p.Thr219Ala
rs2042200 - p.Ala4Val

Additional dbSNP identifiers (rs#s) for ZNF426 Gene

Variation tolerance for ZNF426 Gene

Residual Variation Intolerance Score: 13.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 10.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF426 Gene

Human Gene Mutation Database (HGMD)
ZNF426
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF426

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ZNF426 Gene

Disorders for ZNF426 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF426 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
kaposi sarcoma
  • kaposi sarcoma, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF426: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF426 Gene

Publications for ZNF426 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. An inter-species protein-protein interaction network across vast evolutionary distance. (PMID: 27107014) Zhong Q … Vidal M (Molecular systems biology 2016) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3

Products for ZNF426 Gene

Sources for ZNF426 Gene