Aliases for ZNF425 Gene

Aliases for ZNF425 Gene

  • Zinc Finger Protein 425 2 3 4 5
  • ZNF425 5

External Ids for ZNF425 Gene

Previous GeneCards Identifiers for ZNF425 Gene

  • GC00U902913
  • GC07M148237
  • GC07M148430
  • GC07M148799
  • GC07M142877

Summaries for ZNF425 Gene

GeneCards Summary for ZNF425 Gene

ZNF425 (Zinc Finger Protein 425) is a Protein Coding gene. Diseases associated with ZNF425 include Epiglottitis. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF133.

UniProtKB/Swiss-Prot Summary for ZNF425 Gene

Additional gene information for ZNF425 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF425 Gene

Genomics for ZNF425 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF425 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF425 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF425

Top Transcription factor binding sites by QIAGEN in the ZNF425 gene promoter:
  • Brachyury
  • C/EBPbeta
  • E47
  • HOXA3
  • HTF
  • POU3F2
  • Tal-1beta
  • XBP-1

Genomic Locations for ZNF425 Gene

Genomic Locations for ZNF425 Gene
chr7:149,102,784-149,126,324
(GRCh38/hg38)
Size:
23,541 bases
Orientation:
Minus strand
chr7:148,799,876-148,823,438
(GRCh37/hg19)
Size:
23,563 bases
Orientation:
Minus strand

Genomic View for ZNF425 Gene

Genes around ZNF425 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF425 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF425 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF425 Gene

Proteins for ZNF425 Gene

  • Protein details for ZNF425 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IV72-ZN425_HUMAN
    Recommended name:
    Zinc finger protein 425
    Protein Accession:
    Q6IV72
    Secondary Accessions:
    • B3KPM1
    • Q08AG3

    Protein attributes for ZNF425 Gene

    Size:
    752 amino acids
    Molecular mass:
    87721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF425 Gene

Post-translational modifications for ZNF425 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF425 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF425 Gene

Domains & Families for ZNF425 Gene

Gene Families for ZNF425 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF425 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF425 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 425 (ZN425_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6IV72

UniProtKB/Swiss-Prot:

ZN425_HUMAN :
  • The C2H2 domain is necessary for the transcriptional repression.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The C2H2 domain is necessary for the transcriptional repression.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF425: view

Function for ZNF425 Gene

Molecular function for ZNF425 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor.

Phenotypes From GWAS Catalog for ZNF425 Gene

Gene Ontology (GO) - Molecular Function for ZNF425 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZNF425: view
genes like me logo Genes that share phenotypes with ZNF425: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF425

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF425 Gene

Localization for ZNF425 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF425 Gene

Nucleus. Cytoplasm. Note=Predominantly expressed in the nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF425 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF425 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 21266108
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 21266108
genes like me logo Genes that share ontologies with ZNF425: view

Pathways & Interactions for ZNF425 Gene

genes like me logo Genes that share pathways with ZNF425: view

Pathways by source for ZNF425 Gene

2 Reactome pathways for ZNF425 Gene
1 KEGG pathway for ZNF425 Gene

Interacting Proteins for ZNF425 Gene

Gene Ontology (GO) - Biological Process for ZNF425 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 21266108
genes like me logo Genes that share ontologies with ZNF425: view

No data available for SIGNOR curated interactions for ZNF425 Gene

Drugs & Compounds for ZNF425 Gene

No Compound Related Data Available

Transcripts for ZNF425 Gene

mRNA/cDNA for ZNF425 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF425

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF425 Gene

No ASD Table

Relevant External Links for ZNF425 Gene

GeneLoc Exon Structure for
ZNF425

Expression for ZNF425 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF425 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF425

SOURCE GeneReport for Unigene cluster for ZNF425 Gene:

Hs.31743

Evidence on tissue expression from TISSUES for ZNF425 Gene

  • Heart(4)
genes like me logo Genes that share expression patterns with ZNF425: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF425 Gene

Orthologs for ZNF425 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF425 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF425 30 31
  • 99.47 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF425 31
  • 71 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 41 (a)
OneToMany
-- 31
  • 33 (a)
OneToMany
Species where no ortholog for ZNF425 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF425 Gene

ENSEMBL:
Gene Tree for ZNF425 (if available)
TreeFam:
Gene Tree for ZNF425 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF425: view image

Paralogs for ZNF425 Gene

(307) SIMAP similar genes for ZNF425 Gene using alignment to 2 proteins:

  • ZN425_HUMAN
  • C9JNW7_HUMAN
genes like me logo Genes that share paralogs with ZNF425: view

Variants for ZNF425 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF425 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs6965052 - p.Asp166Val

Additional dbSNP identifiers (rs#s) for ZNF425 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF425 Gene

Variant ID Type Subtype PubMed ID
dgv3692n106 CNV deletion 24896259
esv1422572 CNV deletion 17803354
esv2396942 CNV deletion 18987734
esv2458810 CNV deletion 19546169
esv2668984 CNV deletion 23128226
esv2735327 CNV deletion 23290073
esv3542626 CNV deletion 23714750
esv3615426 CNV loss 21293372
esv7630 CNV loss 19470904
nsv1018754 CNV gain 25217958
nsv1076964 CNV deletion 25765185
nsv1147688 CNV deletion 26484159
nsv955965 CNV deletion 24416366

Variation tolerance for ZNF425 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF425 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF425

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF425 Gene

Disorders for ZNF425 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF425 Gene - From: DISEASES

Disorder Aliases PubMed IDs
epiglottitis
  • acute epiglottitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF425

genes like me logo Genes that share disorders with ZNF425: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF425 Gene

Publications for ZNF425 Gene

  1. A novel human KRAB-related zinc finger gene ZNF425 inhibits mitogen-activated protein kinase signaling pathway. (PMID: 21266108) Wang Y … Wu X (BMB reports 2011) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4

Products for ZNF425 Gene

Sources for ZNF425 Gene