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Aliases for ZNF425 Gene

Aliases for ZNF425 Gene

  • Zinc Finger Protein 425 2 3 5

External Ids for ZNF425 Gene

Previous GeneCards Identifiers for ZNF425 Gene

  • GC00U902913
  • GC07M148237
  • GC07M148430
  • GC07M148799
  • GC07M142877

Summaries for ZNF425 Gene

GeneCards Summary for ZNF425 Gene

ZNF425 (Zinc Finger Protein 425) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF786.

UniProtKB/Swiss-Prot for ZNF425 Gene

  • Acts as a transcriptional repressor.

Additional gene information for ZNF425 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF425 Gene

Genomics for ZNF425 Gene

GeneHancer (GH) Regulatory Elements for ZNF425 Gene

Promoters and enhancers for ZNF425 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I149124 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 586.9 -0.5 -480 3.8 CLOCK MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZFP41 ZNF398 ZNF425 RN7SL521P GC07M149126 ZNF212 ZNF282 ZNF783 ENSG00000271664 ZNF767P CUL1
GH07I149143 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 38.8 -20.2 -20178 7 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A ZNF2 YY1 POLR2B ZNF398 GC07P149148 GC07P149147 ZNF282 ZNF783 ZNF212 ZNF425 ENSG00000271664 ZNF786 LOC155060
GH07I149089 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 20.9 +35.4 35385 2.3 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF786 ZNF425 ZNF783 LOC155060 ZNF212 ENSG00000271664 ZNF767P ZNF862 ZNF777 CUL1
GH07I149064 Enhancer 1.3 Ensembl ENCODE 31.4 +60.8 60803 2.1 HDGF SMAD1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF398 ZNF212 ZNF425 ZNF786 ZNF783 ZNF746 ZNF282 ENSG00000271664 RNU6-650P PDIA4
GH07I149194 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.6 -70.1 -70074 3.1 HDGF SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF282 ZNF212 RN7SL521P ZNF398 ZNF425 ZNF783
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF425 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF425 gene promoter:

Genomic Locations for ZNF425 Gene

Genomic Locations for ZNF425 Gene
23,563 bases
Minus strand

Genomic View for ZNF425 Gene

Genes around ZNF425 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF425 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF425 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF425 Gene

Proteins for ZNF425 Gene

  • Protein details for ZNF425 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 425
    Protein Accession:
    Secondary Accessions:
    • B3KPM1
    • Q08AG3

    Protein attributes for ZNF425 Gene

    752 amino acids
    Molecular mass:
    87721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF425 Gene

Post-translational modifications for ZNF425 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF425 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF425 Gene

Domains & Families for ZNF425 Gene

Gene Families for ZNF425 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF425 Gene

Suggested Antigen Peptide Sequences for ZNF425 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The C2H2 domain is necessary for the transcriptional repression.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • The C2H2 domain is necessary for the transcriptional repression.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF425: view

Function for ZNF425 Gene

Molecular function for ZNF425 Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor.

Phenotypes From GWAS Catalog for ZNF425 Gene

Gene Ontology (GO) - Molecular Function for ZNF425 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF425: view

Phenotypes for ZNF425 Gene

genes like me logo Genes that share phenotypes with ZNF425: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF425 Gene

Localization for ZNF425 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF425 Gene

Nucleus. Cytoplasm. Note=Predominantly expressed in the nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF425 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF425 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 21266108
GO:0005737 cytoplasm IDA,IEA 21266108
genes like me logo Genes that share ontologies with ZNF425: view

Pathways & Interactions for ZNF425 Gene

SuperPathways for ZNF425 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF425: view

Pathways by source for ZNF425 Gene

2 Reactome pathways for ZNF425 Gene

Gene Ontology (GO) - Biological Process for ZNF425 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 21266108
genes like me logo Genes that share ontologies with ZNF425: view

No data available for SIGNOR curated interactions for ZNF425 Gene

Drugs & Compounds for ZNF425 Gene

No Compound Related Data Available

Transcripts for ZNF425 Gene

mRNA/cDNA for ZNF425 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF425 Gene

Zinc finger protein 425:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF425 Gene

No ASD Table

Relevant External Links for ZNF425 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF425 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF425 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF425 Gene:


SOURCE GeneReport for Unigene cluster for ZNF425 Gene:


Evidence on tissue expression from TISSUES for ZNF425 Gene

  • Heart(4)
genes like me logo Genes that share expression patterns with ZNF425: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF425 Gene

Orthologs for ZNF425 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF425 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF425 33 34
  • 99.47 (n)
(Canis familiaris)
Mammalia ZNF425 34
  • 71 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 41 (a)
-- 34
  • 33 (a)
Species where no ortholog for ZNF425 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF425 Gene

Gene Tree for ZNF425 (if available)
Gene Tree for ZNF425 (if available)

Paralogs for ZNF425 Gene

Paralogs for ZNF425 Gene

(307) SIMAP similar genes for ZNF425 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF425: view

Variants for ZNF425 Gene

Sequence variations from dbSNP and Humsavar for ZNF425 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000049038 -- 149,125,009(-) A/C intron_variant
rs1000103298 -- 149,122,653(-) G/A intron_variant
rs1000177579 -- 149,109,983(-) T/A intron_variant
rs1000398837 -- 149,125,310(-) G/A intron_variant
rs1001074488 -- 149,106,740(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF425 Gene

Variant ID Type Subtype PubMed ID
dgv3692n106 CNV deletion 24896259
esv1422572 CNV deletion 17803354
esv2396942 CNV deletion 18987734
esv2458810 CNV deletion 19546169
esv2668984 CNV deletion 23128226
esv2735327 CNV deletion 23290073
esv3542626 CNV deletion 23714750
esv3615426 CNV loss 21293372
esv7630 CNV loss 19470904
nsv1018754 CNV gain 25217958
nsv1076964 CNV deletion 25765185
nsv1147688 CNV deletion 26484159
nsv955965 CNV deletion 24416366

Variation tolerance for ZNF425 Gene

Residual Variation Intolerance Score: 29.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.38; 42.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF425 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF425 Gene

Disorders for ZNF425 Gene

Additional Disease Information for ZNF425

No disorders were found for ZNF425 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF425 Gene

Publications for ZNF425 Gene

  1. A novel human KRAB-related zinc finger gene ZNF425 inhibits mitogen-activated protein kinase signaling pathway. (PMID: 21266108) Wang Y … Wu X (BMB reports 2011) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 58

Products for ZNF425 Gene

Sources for ZNF425 Gene

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