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Aliases for ZNF420 Gene

Aliases for ZNF420 Gene

  • Zinc Finger Protein 420 2 3 5
  • ATM And P53-Associated KZNF Protein 3
  • APAK 3

External Ids for ZNF420 Gene

Previous GeneCards Identifiers for ZNF420 Gene

  • GC00U900995
  • GC19P042262
  • GC19P037569
  • GC19P034038
  • GC19P037498

Summaries for ZNF420 Gene

Entrez Gene Summary for ZNF420 Gene

  • The protein encoded by this gene is a KRAB-type zinc finger protein that negatively-regulates p53-mediated apoptosis. Under stress conditions, the encoded protein is phosphorylated by ATM and dissociates from p53, which activates p53 and initiates apoptosis. [provided by RefSeq, Jul 2016]

GeneCards Summary for ZNF420 Gene

ZNF420 (Zinc Finger Protein 420) is a Protein Coding gene. Among its related pathways are Gene Expression and TP53 Regulates Transcription of Cell Death Genes. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF850.

UniProtKB/Swiss-Prot for ZNF420 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF420 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF420 Gene

Genomics for ZNF420 Gene

GeneHancer (GH) Regulatory Elements for ZNF420 Gene

Promoters and enhancers for ZNF420 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I037077 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 603.4 +70.6 70621 2.5 HDGF SMAD1 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF416 ZNF207 ZNF143 ZNF420 ENSG00000267345 LOC105372390 ZNF567 ZNF383 ZNF527 ZNF345 ZNF585B HKR1 ZFP30
GH19I037007 Promoter 0.9 Ensembl 550.8 0.0 -12 0.8 ZNF639 RFX1 ZBTB2 NRF1 ELF1 GABPA ZNF83 ZNF148 ZNF420 LINC01535 GC19M038832
GH19I037593 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 143 +586.9 586888 2.2 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 SLC30A9 ZNF213 ZNF571 ZNF540 ZNF567 ZNF527 ZFP30 ZNF383 HKR1 ZNF345 ZNF585A ZNF607
GH19I037653 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 126.7 +647.5 647487 3 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF416 ZNF143 ZNF548 SP3 ZFP30 ZNF527 ZNF567 ZNF383 ZNF345 ZNF571 ZNF790 HKR1 ZNF850 ZNF585A
GH19I037370 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 124.5 +363.2 363227 1.9 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF213 ZNF527 ZNF567 ZNF383 ZNF345 ZFP30 ZNF571 HKR1 ZNF850 ZNF793 ZNF790
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF420 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF420 gene promoter:

Genomic Locations for ZNF420 Gene

Genomic Locations for ZNF420 Gene
chr19:37,007,813-37,130,324
(GRCh38/hg38)
Size:
122,512 bases
Orientation:
Plus strand
chr19:37,498,759-37,621,216
(GRCh37/hg19)

Genomic View for ZNF420 Gene

Genes around ZNF420 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF420 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF420 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF420 Gene

Proteins for ZNF420 Gene

  • Protein details for ZNF420 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAQ5-ZN420_HUMAN
    Recommended name:
    Zinc finger protein 420
    Protein Accession:
    Q8TAQ5
    Secondary Accessions:
    • B2RDY6
    • Q96ML5

    Protein attributes for ZNF420 Gene

    Size:
    688 amino acids
    Molecular mass:
    80247 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF420 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF420 Gene

Post-translational modifications for ZNF420 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF420 Gene

Domains & Families for ZNF420 Gene

Gene Families for ZNF420 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF420 Gene

Suggested Antigen Peptide Sequences for ZNF420 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF420: view

No data available for UniProtKB/Swiss-Prot for ZNF420 Gene

Function for ZNF420 Gene

Molecular function for ZNF420 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF420 Gene

Gene Ontology (GO) - Molecular Function for ZNF420 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 20713054
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF420: view
genes like me logo Genes that share phenotypes with ZNF420: view

Animal Model Products

CRISPR Products

miRNA for ZNF420 Gene

miRTarBase miRNAs that target ZNF420

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF420 Gene

Localization for ZNF420 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF420 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF420 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF420 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0070062 extracellular exosome IDA,HDA 23376485
genes like me logo Genes that share ontologies with ZNF420: view

Pathways & Interactions for ZNF420 Gene

genes like me logo Genes that share pathways with ZNF420: view

Gene Ontology (GO) - Biological Process for ZNF420 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0042981 regulation of apoptotic process TAS --
genes like me logo Genes that share ontologies with ZNF420: view

No data available for SIGNOR curated interactions for ZNF420 Gene

Drugs & Compounds for ZNF420 Gene

No Compound Related Data Available

Transcripts for ZNF420 Gene

Unigene Clusters for ZNF420 Gene

Zinc finger protein 420:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF420 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8
SP1: - -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for ZNF420 Gene

GeneLoc Exon Structure for
ZNF420
ECgene alternative splicing isoforms for
ZNF420

Expression for ZNF420 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF420 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZNF420 Gene:

ZNF420

SOURCE GeneReport for Unigene cluster for ZNF420 Gene:

Hs.444992

Evidence on tissue expression from TISSUES for ZNF420 Gene

  • Muscle(4.2)
genes like me logo Genes that share expression patterns with ZNF420: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF420 Gene

Orthologs for ZNF420 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF420 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF420 34
  • 100 (a)
OneToOne
LOC101059449 33
  • 99.76 (n)
dog
(Canis familiaris)
Mammalia ZNF420 34
  • 94 (a)
OneToOne
LOC100682968 33
  • 90.61 (n)
cow
(Bos Taurus)
Mammalia ZNF420 33 34
  • 92.67 (n)
mouse
(Mus musculus)
Mammalia Zfp420 33 16 34
  • 85.18 (n)
rat
(Rattus norvegicus)
Mammalia Zfp420 33
  • 83.62 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 55 (a)
OneToMany
Species where no ortholog for ZNF420 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF420 Gene

ENSEMBL:
Gene Tree for ZNF420 (if available)
TreeFam:
Gene Tree for ZNF420 (if available)

Paralogs for ZNF420 Gene

(563) SIMAP similar genes for ZNF420 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for ZNF420 Gene

genes like me logo Genes that share paralogs with ZNF420: view

Variants for ZNF420 Gene

Sequence variations from dbSNP and Humsavar for ZNF420 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs771433810 uncertain-significance, Ductal breast carcinoma 37,127,353(+) A/G coding_sequence_variant, missense_variant
rs1000046487 -- 37,118,271(+) T/A intron_variant
rs1000067100 -- 37,072,655(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000071744 -- 37,099,350(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000076432 -- 37,044,223(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF420 Gene

Variant ID Type Subtype PubMed ID
esv3644277 CNV gain 21293372
esv3893201 CNV gain 25118596
nsv1064851 CNV loss 25217958
nsv2477 CNV deletion 18451855
nsv579461 CNV gain 21841781
nsv833818 CNV gain 17160897
nsv953292 CNV duplication 24416366

Variation tolerance for ZNF420 Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 21.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF420 Gene

Human Gene Mutation Database (HGMD)
ZNF420
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF420

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF420 Gene

Disorders for ZNF420 Gene

Additional Disease Information for ZNF420

No disorders were found for ZNF420 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF420 Gene

Publications for ZNF420 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Agonist-specific Protein Interactomes of Glucocorticoid and Androgen Receptor as Revealed by Proximity Mapping. (PMID: 28611094) Lempiäinen JK … Palvimo JJ (Molecular & cellular proteomics : MCP 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZNF420 Gene

Sources for ZNF420 Gene

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