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Aliases for ZNF419 Gene

Aliases for ZNF419 Gene

  • Zinc Finger Protein 419 2 3 5
  • Zinc Finger Protein 419A 2 3
  • ZNF419A 3 4
  • ZAPHIR 3

External Ids for ZNF419 Gene

Previous HGNC Symbols for ZNF419 Gene

  • ZNF419A

Previous GeneCards Identifiers for ZNF419 Gene

  • GC00U900993
  • GC19P062691
  • GC19P057999
  • GC19P054311

Summaries for ZNF419 Gene

GeneCards Summary for ZNF419 Gene

ZNF419 (Zinc Finger Protein 419) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF773.

UniProtKB/Swiss-Prot for ZNF419 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF419 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF419 Gene

Genomics for ZNF419 Gene

GeneHancer (GH) Regulatory Elements for ZNF419 Gene

Promoters and enhancers for ZNF419 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I057487 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 585.6 +0.3 333 1.9 HDGF PKNOX1 ATF1 ARID4B SIN3A YBX1 ZNF48 YY1 ETS1 ELK1 ZNF419 GC19P057489 ENSG00000268107 VN1R1 ZNF264 ZNF773 ZNF543 ZNF805 ZNF550 ZNF544
GH19I057499 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 48 +12.5 12510 1.9 HDGF PKNOX1 ARID4B SIN3A DMAP1 YBX1 ZNF2 ZNF48 YY1 ETS1 ZNF773 ZNF419 ZNF264 ZNF805 ZNF543 ZNF548 ZNF550 ZNF134 VN1R1 ZNF417
GH19I058325 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.9 +839.2 839160 3.6 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZSCAN22 LOC105372480 PIR44424 ZNF134 ZNF606 ZNF417 ZNF549 ZNF135 ZNF17 ZNF446
GH19I058181 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.1 +695.5 695525 2.5 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF274 ZNF134 ZNF606 ZNF17 ZNF417 ZNF549 ZNF550 ZNF773 LOC105372483 ZNF264
GH19I057599 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 22.3 +112.3 112326 1.5 PKNOX1 SMAD1 ARID4B SIN3A DMAP1 YY1 E2F8 ZNF207 ZNF143 KLF13 ZNF530 ZNF606 ZNF549 ZNF135 ZNF417 ZNF132 ZNF418 ZNF446 ZNF17 LOC105372482
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF419 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF419 gene promoter:

Genomic Locations for ZNF419 Gene

Genomic Locations for ZNF419 Gene
8,387 bases
Plus strand

Genomic View for ZNF419 Gene

Genes around ZNF419 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF419 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF419 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF419 Gene

Proteins for ZNF419 Gene

  • Protein details for ZNF419 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 419
    Protein Accession:
    Secondary Accessions:
    • B4DXU7
    • B4E348
    • B7ZA41
    • E9PCP4
    • E9PED0
    • E9PET3
    • E9PFX9
    • Q9H5P0

    Protein attributes for ZNF419 Gene

    510 amino acids
    Molecular mass:
    58564 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF419 Gene

neXtProt entry for ZNF419 Gene

Post-translational modifications for ZNF419 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF419 Gene

Domains & Families for ZNF419 Gene

Gene Families for ZNF419 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transcription factors

Protein Domains for ZNF419 Gene

Suggested Antigen Peptide Sequences for ZNF419 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF419: view

Function for ZNF419 Gene

Molecular function for ZNF419 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF419 Gene

Gene Ontology (GO) - Molecular Function for ZNF419 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF419: view

Phenotypes for ZNF419 Gene

genes like me logo Genes that share phenotypes with ZNF419: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF419 Gene

Localization for ZNF419 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF419 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF419 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF419 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF419: view

Pathways & Interactions for ZNF419 Gene

SuperPathways for ZNF419 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF419: view

Pathways by source for ZNF419 Gene

2 Reactome pathways for ZNF419 Gene

Gene Ontology (GO) - Biological Process for ZNF419 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF419: view

No data available for SIGNOR curated interactions for ZNF419 Gene

Drugs & Compounds for ZNF419 Gene

No Compound Related Data Available

Transcripts for ZNF419 Gene

Unigene Clusters for ZNF419 Gene

Zinc finger protein 419:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF419 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c
SP1: - - -
SP2: - - - -
SP3: -
SP4: - -
SP5: -
SP6: - -
SP7: - - - - -

Relevant External Links for ZNF419 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF419 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF419 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of ZNF419 Gene:


SOURCE GeneReport for Unigene cluster for ZNF419 Gene:


Evidence on tissue expression from TISSUES for ZNF419 Gene

  • Nervous system(4.4)
  • Skin(4.2)
  • Heart(4.1)
genes like me logo Genes that share expression patterns with ZNF419: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF419 Gene

Orthologs for ZNF419 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF419 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF419 33
  • 98.69 (n)
-- 34
  • 97 (a)
(Canis familiaris)
Mammalia ZNF419 33
  • 82.51 (n)
(Bos Taurus)
Mammalia ZNF419 33
  • 81.75 (n)
-- 34
  • 71 (a)
(Mus musculus)
Mammalia Zfp600 34
  • 29 (a)
Species where no ortholog for ZNF419 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF419 Gene

Gene Tree for ZNF419 (if available)
Gene Tree for ZNF419 (if available)

Paralogs for ZNF419 Gene

(529) SIMAP similar genes for ZNF419 Gene using alignment to 10 proteins: Pseudogenes for ZNF419 Gene

genes like me logo Genes that share paralogs with ZNF419: view

Variants for ZNF419 Gene

Sequence variations from dbSNP and Humsavar for ZNF419 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs193920918 uncertain-significance, Malignant tumor of prostate 57,491,471(+) G/T 5_prime_UTR_variant, coding_sequence_variant, missense_variant
rs1000023151 -- 57,488,614(+) G/A/T intron_variant
rs1000354670 -- 57,488,782(+) G/C intron_variant
rs1000836462 -- 57,493,464(+) G/C coding_sequence_variant, intron_variant, missense_variant
rs1001676393 -- 57,486,782(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF419 Gene

Variant ID Type Subtype PubMed ID
dgv3684n100 CNV gain 25217958
esv24439 CNV gain 19812545
esv2719071 CNV deletion 23290073
esv2758774 CNV gain 17122850
esv3575097 CNV gain 25503493
esv3575108 CNV gain 25503493
esv3583609 CNV loss 25503493
esv3644903 CNV gain 21293372
nsv1056203 CNV gain 25217958
nsv1067145 CNV gain 25217958
nsv522762 CNV loss 19592680
nsv580401 CNV gain 21841781
nsv828655 CNV gain 20364138
nsv963083 CNV duplication 23825009

Variation tolerance for ZNF419 Gene

Residual Variation Intolerance Score: 84.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.79% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF419 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF419 Gene

Disorders for ZNF419 Gene

Additional Disease Information for ZNF419

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF419 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF419 Gene

Publications for ZNF419 Gene

  1. A polymorphism in the splice donor site of ZNF419 results in the novel renal cell carcinoma-associated minor histocompatibility antigen ZAPHIR. (PMID: 21738768) Broen K … Dolstra H (PloS one 2011) 2 3 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Allele-specific splicing effects on DKKL1 and ZNF419 transcripts in HeLa cells. (PMID: 27826023) Martin G … Spillane C (Gene 2017) 3 58

Products for ZNF419 Gene

Sources for ZNF419 Gene

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