Aliases for ZNF418 Gene

Aliases for ZNF418 Gene

  • Zinc Finger Protein 418 2 3 4 5
  • KIAA1956 2 4
  • FLJ31551 2
  • ZNF418 5

External Ids for ZNF418 Gene

Previous GeneCards Identifiers for ZNF418 Gene

  • GC00U900991
  • GC19M063129
  • GC19M062988
  • GC19M058296
  • GC19M054744
  • GC19M058433

Summaries for ZNF418 Gene

GeneCards Summary for ZNF418 Gene

ZNF418 (Zinc Finger Protein 418) is a Protein Coding gene. Diseases associated with ZNF418 include Ovarian Squamous Cell Carcinoma. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF256.

UniProtKB/Swiss-Prot Summary for ZNF418 Gene

Additional gene information for ZNF418 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF418 Gene

Genomics for ZNF418 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF418 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF418 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF418

Top Transcription factor binding sites by QIAGEN in the ZNF418 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • GATA-2
  • GATA-3

Genomic Locations for ZNF418 Gene

Genomic Locations for ZNF418 Gene
chr19:57,921,882-57,935,403
(GRCh38/hg38)
Size:
13,522 bases
Orientation:
Minus strand
chr19:58,433,252-58,446,761
(GRCh37/hg19)
Size:
13,510 bases
Orientation:
Minus strand

Genomic View for ZNF418 Gene

Genes around ZNF418 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF418 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF418 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF418 Gene

Proteins for ZNF418 Gene

  • Protein details for ZNF418 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF45-ZN418_HUMAN
    Recommended name:
    Zinc finger protein 418
    Protein Accession:
    Q8TF45
    Secondary Accessions:
    • Q2M1S2
    • Q670L5
    • Q96N18

    Protein attributes for ZNF418 Gene

    Size:
    676 amino acids
    Molecular mass:
    77858 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85542.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF418 Gene

Post-translational modifications for ZNF418 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF418 Gene

Domains & Families for ZNF418 Gene

Gene Families for ZNF418 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF418 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF418 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50380, highly similar to Zinc finger protein 418 (B7Z993_HUMAN)
  • Zinc finger protein 418 (ZN418_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TF45

UniProtKB/Swiss-Prot:

ZN418_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF418: view

Function for ZNF418 Gene

Molecular function for ZNF418 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor.

Phenotypes From GWAS Catalog for ZNF418 Gene

Gene Ontology (GO) - Molecular Function for ZNF418 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF418: view
genes like me logo Genes that share phenotypes with ZNF418: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF418

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF418 Gene

Localization for ZNF418 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF418 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF418 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF418 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF418: view

Pathways & Interactions for ZNF418 Gene

genes like me logo Genes that share pathways with ZNF418: view

Pathways by source for ZNF418 Gene

2 Reactome pathways for ZNF418 Gene
1 KEGG pathway for ZNF418 Gene

Interacting Proteins for ZNF418 Gene

Gene Ontology (GO) - Biological Process for ZNF418 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF418: view

No data available for SIGNOR curated interactions for ZNF418 Gene

Drugs & Compounds for ZNF418 Gene

No Compound Related Data Available

Transcripts for ZNF418 Gene

mRNA/cDNA for ZNF418 Gene

5 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF418

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF418 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - -
SP5: - - - - - -
SP6: - -
SP7: -
SP8: - - - - -
SP9: - - - - -
SP10: -

Relevant External Links for ZNF418 Gene

GeneLoc Exon Structure for
ZNF418

Expression for ZNF418 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF418 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF418

SOURCE GeneReport for Unigene cluster for ZNF418 Gene:

Hs.660728

Evidence on tissue expression from TISSUES for ZNF418 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF418: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF418 Gene

Orthologs for ZNF418 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF418 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF418 30 31
  • 99.18 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 54 (a)
OneToMany
Species where no ortholog for ZNF418 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF418 Gene

ENSEMBL:
Gene Tree for ZNF418 (if available)
TreeFam:
Gene Tree for ZNF418 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF418: view image

Paralogs for ZNF418 Gene

(548) SIMAP similar genes for ZNF418 Gene using alignment to 8 proteins:

  • ZN418_HUMAN
  • J3KQR4_HUMAN
  • L8E947_HUMAN
  • M0QX21_HUMAN
  • M0QX82_HUMAN
  • M0QXB3_HUMAN
  • M0QYW9_HUMAN
  • M0R1R2_HUMAN
genes like me logo Genes that share paralogs with ZNF418: view

Variants for ZNF418 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF418 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
719583 Likely Benign: not provided 57,927,979(-) G/A NONSENSE,FIVE_PRIME_UTR_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF418 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF418 Gene

Variant ID Type Subtype PubMed ID
esv2656655 CNV deletion 23128226
esv2719096 CNV deletion 23290073
esv3644913 CNV gain 21293372
esv3644916 CNV loss 21293372
esv3893258 CNV gain 25118596
nsv1066059 CNV gain 25217958

Variation tolerance for ZNF418 Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF418 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF418

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF418 Gene

Disorders for ZNF418 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF418 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovarian squamous cell carcinoma
  • ovarian squamous cell tumor
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF418: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF418 Gene

Publications for ZNF418 Gene

  1. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. miR-1204 promotes hepatocellular carcinoma progression through activating MAPK and c-Jun/AP1 signaling by targeting ZNF418. (PMID: 31337980) Wang L … Liu Z (International journal of biological sciences 2019) 3

Products for ZNF418 Gene

Sources for ZNF418 Gene