Aliases for ZNF417 Gene

Aliases for ZNF417 Gene

  • Zinc Finger Protein 417 2 3 4 5
  • MGC34079 2
  • ZNF417 5

External Ids for ZNF417 Gene

Previous GeneCards Identifiers for ZNF417 Gene

  • GC00U900990
  • GC19M063111
  • GC19M058417
  • GC19M054728

Summaries for ZNF417 Gene

GeneCards Summary for ZNF417 Gene

ZNF417 (Zinc Finger Protein 417) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF587.

UniProtKB/Swiss-Prot Summary for ZNF417 Gene

Additional gene information for ZNF417 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF417 Gene

Genomics for ZNF417 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF417 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF417 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF417

Genomic Locations for ZNF417 Gene

Genomic Locations for ZNF417 Gene
chr19:57,900,296-57,916,610
(GRCh38/hg38)
Size:
16,315 bases
Orientation:
Minus strand
chr19:58,411,664-58,427,978
(GRCh37/hg19)
Size:
16,315 bases
Orientation:
Minus strand

Genomic View for ZNF417 Gene

Genes around ZNF417 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF417 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF417 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF417 Gene

Proteins for ZNF417 Gene

  • Protein details for ZNF417 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAU3-ZN417_HUMAN
    Recommended name:
    Zinc finger protein 417
    Protein Accession:
    Q8TAU3
    Secondary Accessions:
    • B4DEU1

    Protein attributes for ZNF417 Gene

    Size:
    575 amino acids
    Molecular mass:
    65733 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF417 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF417 Gene

Post-translational modifications for ZNF417 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF417 Gene

Domains & Families for ZNF417 Gene

Gene Families for ZNF417 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF417 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF417 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ58363, highly similar to Zinc finger protein 417 (B4DEU1_HUMAN)
  • Zinc finger protein 417 (ZN417_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TAU3

UniProtKB/Swiss-Prot:

ZN417_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF417: view

Function for ZNF417 Gene

Molecular function for ZNF417 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF417 Gene

Gene Ontology (GO) - Molecular Function for ZNF417 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF417: view
genes like me logo Genes that share phenotypes with ZNF417: view

Animal Model Products

CRISPR Products

miRNA for ZNF417 Gene

miRTarBase miRNAs that target ZNF417

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF417

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF417 Gene

Localization for ZNF417 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF417 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF417 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF417 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF417: view

Pathways & Interactions for ZNF417 Gene

genes like me logo Genes that share pathways with ZNF417: view

Pathways by source for ZNF417 Gene

2 Reactome pathways for ZNF417 Gene
1 KEGG pathway for ZNF417 Gene

Gene Ontology (GO) - Biological Process for ZNF417 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF417: view

No data available for SIGNOR curated interactions for ZNF417 Gene

Drugs & Compounds for ZNF417 Gene

No Compound Related Data Available

Transcripts for ZNF417 Gene

mRNA/cDNA for ZNF417 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF417

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF417 Gene

No ASD Table

Relevant External Links for ZNF417 Gene

GeneLoc Exon Structure for
ZNF417

Expression for ZNF417 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF417 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF417 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF417

SOURCE GeneReport for Unigene cluster for ZNF417 Gene:

Hs.567710

Evidence on tissue expression from TISSUES for ZNF417 Gene

  • Nervous system(4.3)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with ZNF417: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF417 Gene

Orthologs for ZNF417 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF417 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia -- 31
  • 98 (a)
ManyToMany
-- 31
  • 96 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia -- 31
  • 52 (a)
OneToMany
Species where no ortholog for ZNF417 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF417 Gene

ENSEMBL:
Gene Tree for ZNF417 (if available)
TreeFam:
Gene Tree for ZNF417 (if available)

Paralogs for ZNF417 Gene

(535) SIMAP similar genes for ZNF417 Gene using alignment to 8 proteins:

  • ZN417_HUMAN
  • B4DEU1_HUMAN
  • M0QXH9_HUMAN
  • M0R0M6_HUMAN
  • M0R0V5_HUMAN
  • M0R178_HUMAN
  • M0R230_HUMAN
  • M0R267_HUMAN
genes like me logo Genes that share paralogs with ZNF417: view

Variants for ZNF417 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF417 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
769989 Benign: not provided 57,909,712(-) G/T MISSENSE_VARIANT
774743 Benign: not provided 57,908,853(-) A/G SYNONYMOUS_VARIANT
777512 Benign: not provided 57,916,383(-) G/C MISSENSE_VARIANT
rs10416584 - p.Asn495Ser

Additional dbSNP identifiers (rs#s) for ZNF417 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF417 Gene

Variant ID Type Subtype PubMed ID
esv2719094 CNV deletion 23290073
esv3644913 CNV gain 21293372
esv3893258 CNV gain 25118596
nsv1066059 CNV gain 25217958
nsv963085 CNV duplication 23825009

Variation tolerance for ZNF417 Gene

Residual Variation Intolerance Score: 90.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF417 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF417

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF417 Gene

Disorders for ZNF417 Gene

No disorders were found for ZNF417 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF417 Gene

Publications for ZNF417 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3
  5. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N … Vidal M (Cell 2015) 3

Products for ZNF417 Gene

Sources for ZNF417 Gene