Aliases for ZNF416 Gene

Aliases for ZNF416 Gene

  • Zinc Finger Protein 416 2 3 4 5
  • FLJ20557 2
  • ZNF416 5

External Ids for ZNF416 Gene

Previous GeneCards Identifiers for ZNF416 Gene

  • GC00U900989
  • GC19M062775
  • GC19M058082
  • GC19M054395

Summaries for ZNF416 Gene

GeneCards Summary for ZNF416 Gene

ZNF416 (Zinc Finger Protein 416) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF530.

UniProtKB/Swiss-Prot Summary for ZNF416 Gene

Additional gene information for ZNF416 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF416 Gene

Genomics for ZNF416 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF416 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF416 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF416

Top Transcription factor binding sites by QIAGEN in the ZNF416 gene promoter:
  • Arnt
  • c-Ets-1
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • CP1C
  • NF-Y
  • NF-YA

Genomic Locations for ZNF416 Gene

Genomic Locations for ZNF416 Gene
7,913 bases
Minus strand
7,362 bases
Minus strand

Genomic View for ZNF416 Gene

Genes around ZNF416 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF416 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF416 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF416 Gene

Proteins for ZNF416 Gene

  • Protein details for ZNF416 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 416
    Protein Accession:
    Secondary Accessions:
    • Q9NWW8

    Protein attributes for ZNF416 Gene

    594 amino acids
    Molecular mass:
    67188 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91257.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ZNF416 Gene

Post-translational modifications for ZNF416 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF416 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF416 Gene

Domains & Families for ZNF416 Gene

Gene Families for ZNF416 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF416 Gene

  • C2H2-type zinc finger signature
  • KRAB box

Suggested Antigen Peptide Sequences for ZNF416 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 416, isoform CRA_a (O43338_HUMAN)
  • Zinc finger protein 416 (ZN416_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF416: view

Function for ZNF416 Gene

Molecular function for ZNF416 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF416 Gene

Gene Ontology (GO) - Molecular Function for ZNF416 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF416: view
genes like me logo Genes that share phenotypes with ZNF416: view

Animal Model Products

CRISPR Products

miRNA for ZNF416 Gene

Targeted motifs for ZNF416 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF416
  • Consensus sequence: WDNCTGGGCA Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF416

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF416 Gene

Localization for ZNF416 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF416 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF416 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF416 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF416: view

Pathways & Interactions for ZNF416 Gene

genes like me logo Genes that share pathways with ZNF416: view

Pathways by source for ZNF416 Gene

2 Reactome pathways for ZNF416 Gene
1 KEGG pathway for ZNF416 Gene

Gene Ontology (GO) - Biological Process for ZNF416 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF416: view

No data available for SIGNOR curated interactions for ZNF416 Gene

Drugs & Compounds for ZNF416 Gene

No Compound Related Data Available

Transcripts for ZNF416 Gene

mRNA/cDNA for ZNF416 Gene

2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF416

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF416 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for ZNF416 Gene

GeneLoc Exon Structure for

Expression for ZNF416 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF416 Gene

Protein differential expression in normal tissues from HIPED for ZNF416 Gene

This gene is overexpressed in Platelet (51.8) and Peripheral blood mononuclear cells (17.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF416 Gene

Protein tissue co-expression partners for ZNF416 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF416

SOURCE GeneReport for Unigene cluster for ZNF416 Gene:

genes like me logo Genes that share expression patterns with ZNF416: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF416 Gene

Orthologs for ZNF416 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF416 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF416 30 31
  • 99.66 (n)
(Bos Taurus)
Mammalia ZNF416 30
  • 76.33 (n)
-- 31
  • 59 (a)
(Rattus norvegicus)
Mammalia Zfp418 30
  • 68.4 (n)
(Mus musculus)
Mammalia Zfp418 30 17 31
  • 68.3 (n)
Species where no ortholog for ZNF416 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF416 Gene

Gene Tree for ZNF416 (if available)
Gene Tree for ZNF416 (if available)
Evolutionary constrained regions (ECRs) for ZNF416: view image

Paralogs for ZNF416 Gene

(484) SIMAP similar genes for ZNF416 Gene using alignment to 2 proteins:

  • ZN416_HUMAN
  • O43338_HUMAN
genes like me logo Genes that share paralogs with ZNF416: view

Variants for ZNF416 Gene

Additional dbSNP identifiers (rs#s) for ZNF416 Gene

Variation tolerance for ZNF416 Gene

Residual Variation Intolerance Score: 40.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.27; 25.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF416 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for ZNF416 Gene

Disorders for ZNF416 Gene

No disorders were found for ZNF416 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF416 Gene

Publications for ZNF416 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for ZNF416 Gene

Sources for ZNF416 Gene