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Aliases for ZNF414 Gene

Aliases for ZNF414 Gene

  • Zinc Finger Protein 414 2 3 3 5
  • ZFP414 3

External Ids for ZNF414 Gene

Previous GeneCards Identifiers for ZNF414 Gene

  • GC19M008483
  • GC19M008230
  • GC19M008575

Summaries for ZNF414 Gene

GeneCards Summary for ZNF414 Gene

ZNF414 (Zinc Finger Protein 414) is a Protein Coding gene.

UniProtKB/Swiss-Prot for ZNF414 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF414 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF414 Gene

Genomics for ZNF414 Gene

GeneHancer (GH) Regulatory Elements for ZNF414 Gene

Promoters and enhancers for ZNF414 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J008511 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 672 -1.9 -1902 8.4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF766 ZNF414 XAB2 ZNF317 MYO1F ZNF177 ZNF266 PRAM1 HNRNPM MAP2K7 ENSG00000267273
GH19J008361 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 28.3 +150.8 150755 3.6 FOXA2 PKNOX1 ARNT ZFP64 ARID4B SIN3A YY1 FOS DEK ZC3H11A ANGPTL4 HNRNPM ZNF317 XAB2 ZNF699 ZNF558 MAP2K7 ELAVL1 ZNF559 ZNF414
GH19J007521 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 19.8 +991.3 991307 2 MLX FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 SP3 NFYC MCOLN1 GC19M007510 HNRNPM ELAVL1 XAB2 ZNF557 MAP2K7 ZNF414 TIMM44 SNAPC2
GH19J008524 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 29.4 -12.0 -11975 2.4 HDGF FOXA2 PKNOX1 ARNT ARID4B SIN3A ZNF2 POLR2B E2F8 ZNF416 HNRNPM ELAVL1 ZNF558 ZNF699 ZNF317 ZNF266 ZNF559 XAB2 ZNF414 ENSG00000269300
GH19J008319 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 23.2 +192.7 192708 3.6 HDGF HNRNPUL1 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 RPS28 ENSG00000167774 GC19P008321 NDUFA7 HNRNPM XAB2 ZNF317 ZNF699 ZNF558 MAP2K7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF414 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF414 gene promoter:
  • Max
  • c-Myc
  • FOXC1
  • Tal-1
  • E47
  • AREB6
  • MIF-1
  • AML1a
  • c-Ets-1
  • HSF1short

Genomic Locations for ZNF414 Gene

Genomic Locations for ZNF414 Gene
chr19:8,509,678-8,514,164
(GRCh38/hg38)
Size:
4,487 bases
Orientation:
Minus strand
chr19:8,575,462-8,579,048
(GRCh37/hg19)
Size:
3,587 bases
Orientation:
Minus strand

Genomic View for ZNF414 Gene

Genes around ZNF414 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF414 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF414 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF414 Gene

Proteins for ZNF414 Gene

  • Protein details for ZNF414 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IQ9-ZN414_HUMAN
    Recommended name:
    Zinc finger protein 414
    Protein Accession:
    Q96IQ9
    Secondary Accessions:
    • A8MY94

    Protein attributes for ZNF414 Gene

    Size:
    312 amino acids
    Molecular mass:
    32782 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF414 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF414 Gene

Post-translational modifications for ZNF414 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF414 Gene

No data available for DME Specific Peptides for ZNF414 Gene

Domains & Families for ZNF414 Gene

Gene Families for ZNF414 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF414 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF414 Gene

Graphical View of Domain Structure for InterPro Entry

Q96IQ9

UniProtKB/Swiss-Prot:

ZN414_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF414: view

Function for ZNF414 Gene

Molecular function for ZNF414 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF414 Gene

Gene Ontology (GO) - Molecular Function for ZNF414 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21044950
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF414: view
genes like me logo Genes that share phenotypes with ZNF414: view

Animal Model Products

miRNA for ZNF414 Gene

miRTarBase miRNAs that target ZNF414

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF414 Gene

Localization for ZNF414 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF414 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF414 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF414 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF414: view

Pathways & Interactions for ZNF414 Gene

SuperPathways for ZNF414 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF414 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF414: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF414 Gene

Drugs & Compounds for ZNF414 Gene

No Compound Related Data Available

Transcripts for ZNF414 Gene

mRNA/cDNA for ZNF414 Gene

Unigene Clusters for ZNF414 Gene

Zinc finger protein 414:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF414 Gene

No ASD Table

Relevant External Links for ZNF414 Gene

GeneLoc Exon Structure for
ZNF414
ECgene alternative splicing isoforms for
ZNF414

Expression for ZNF414 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF414 Gene

Protein differential expression in normal tissues from HIPED for ZNF414 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (38.4) and Pancreatic juice (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF414 Gene



Protein tissue co-expression partners for ZNF414 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF414 Gene:

ZNF414

SOURCE GeneReport for Unigene cluster for ZNF414 Gene:

Hs.515114

Evidence on tissue expression from TISSUES for ZNF414 Gene

  • Eye(4.2)
  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with ZNF414: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF414 Gene

Orthologs for ZNF414 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF414 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF414 34 33
  • 99.35 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF414 34 33
  • 88.46 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF414 34 33
  • 87.4 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp414 33
  • 81.19 (n)
mouse
(Mus musculus)
Mammalia Zfp414 16 34 33
  • 80 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF414 34
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF414 34
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF414 34
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ZNF414 34
  • 31 (a)
OneToOne
Species where no ortholog for ZNF414 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF414 Gene

ENSEMBL:
Gene Tree for ZNF414 (if available)
TreeFam:
Gene Tree for ZNF414 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF414: view image

Paralogs for ZNF414 Gene

No data available for Paralogs for ZNF414 Gene

Variants for ZNF414 Gene

Sequence variations from dbSNP and Humsavar for ZNF414 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000887123 -- 8,511,029(-) G/T downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1001164823 -- 8,511,997(-) C/T intron_variant
rs1001887416 -- 8,512,260(-) C/A intron_variant
rs1001918505 -- 8,511,983(-) G/A/C/T intron_variant
rs1002900278 -- 8,513,268(-) T/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF414 Gene

Variant ID Type Subtype PubMed ID
dgv137n111 CNV deletion 26073780
dgv396n27 CNV loss 19166990
dgv6258n54 CNV loss 21841781
nsv458350 CNV loss 19166990
nsv578559 CNV loss 21841781
nsv953966 CNV deletion 24416366

Variation tolerance for ZNF414 Gene

Gene Damage Index Score: 10.24; 90.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF414 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF414

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF414 Gene

Disorders for ZNF414 Gene

Additional Disease Information for ZNF414

No disorders were found for ZNF414 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF414 Gene

Publications for ZNF414 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. (PMID: 21044950) Lee OH … Songyang Z (Molecular & cellular proteomics : MCP 2011) 3 58

Products for ZNF414 Gene

Sources for ZNF414 Gene

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