Aliases for ZNF414 Gene

Aliases for ZNF414 Gene

  • Zinc Finger Protein 414 2 3 4 5
  • MGC15716 2
  • ZFP414 3
  • ZNF414 5
  • Zfp414 2

External Ids for ZNF414 Gene

Previous GeneCards Identifiers for ZNF414 Gene

  • GC19M008483
  • GC19M008230
  • GC19M008575

Summaries for ZNF414 Gene

GeneCards Summary for ZNF414 Gene

ZNF414 (Zinc Finger Protein 414) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for ZNF414 Gene

Additional gene information for ZNF414 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF414 Gene

Genomics for ZNF414 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF414 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF414 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF414

Top Transcription factor binding sites by QIAGEN in the ZNF414 gene promoter:
  • AML1a
  • AREB6
  • c-Ets-1
  • c-Myc
  • E47
  • FOXC1
  • HSF1short
  • Max
  • MIF-1
  • Tal-1

Genomic Locations for ZNF414 Gene

Genomic Locations for ZNF414 Gene
chr19:8,509,678-8,514,167
(GRCh38/hg38)
Size:
4,490 bases
Orientation:
Minus strand
chr19:8,575,462-8,579,048
(GRCh37/hg19)
Size:
3,587 bases
Orientation:
Minus strand

Genomic View for ZNF414 Gene

Genes around ZNF414 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF414 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF414 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF414 Gene

Proteins for ZNF414 Gene

  • Protein details for ZNF414 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96IQ9-ZN414_HUMAN
    Recommended name:
    Zinc finger protein 414
    Protein Accession:
    Q96IQ9
    Secondary Accessions:
    • A8MY94

    Protein attributes for ZNF414 Gene

    Size:
    312 amino acids
    Molecular mass:
    32782 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF414 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF414 Gene

Post-translational modifications for ZNF414 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF414 Gene

No data available for DME Specific Peptides for ZNF414 Gene

Domains & Families for ZNF414 Gene

Gene Families for ZNF414 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF414 Gene

Suggested Antigen Peptide Sequences for ZNF414 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 414, isoform CRA_c (A8MY94_HUMAN)
  • Zinc finger protein 414 (ZN414_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96IQ9

UniProtKB/Swiss-Prot:

ZN414_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF414: view

Function for ZNF414 Gene

Molecular function for ZNF414 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF414 Gene

Gene Ontology (GO) - Molecular Function for ZNF414 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21044950
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF414: view
genes like me logo Genes that share phenotypes with ZNF414: view

Animal Model Products

CRISPR Products

miRNA for ZNF414 Gene

miRTarBase miRNAs that target ZNF414

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF414

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF414 Gene

Localization for ZNF414 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF414 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF414 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF414 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF414: view

Pathways & Interactions for ZNF414 Gene

PathCards logo

SuperPathways for ZNF414 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF414 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF414: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF414 Gene

Drugs & Compounds for ZNF414 Gene

No Compound Related Data Available

Transcripts for ZNF414 Gene

mRNA/cDNA for ZNF414 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF414

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF414 Gene

No ASD Table

Relevant External Links for ZNF414 Gene

GeneLoc Exon Structure for
ZNF414

Expression for ZNF414 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF414 Gene

Protein differential expression in normal tissues from HIPED for ZNF414 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (38.4) and Pancreatic juice (19.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF414 Gene



Protein tissue co-expression partners for ZNF414 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF414

SOURCE GeneReport for Unigene cluster for ZNF414 Gene:

Hs.515114

Evidence on tissue expression from TISSUES for ZNF414 Gene

  • Eye(4.2)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with ZNF414: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF414 Gene

Orthologs for ZNF414 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF414 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF414 30 31
  • 99.35 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF414 30 31
  • 88.46 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF414 30 31
  • 87.4 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp414 30
  • 81.19 (n)
Mouse
(Mus musculus)
Mammalia Zfp414 30 17 31
  • 80 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF414 31
  • 60 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZNF414 31
  • 55 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZNF414 31
  • 34 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii ZNF414 31
  • 31 (a)
OneToOne
Species where no ortholog for ZNF414 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF414 Gene

ENSEMBL:
Gene Tree for ZNF414 (if available)
TreeFam:
Gene Tree for ZNF414 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF414: view image

Paralogs for ZNF414 Gene

No data available for Paralogs for ZNF414 Gene

Variants for ZNF414 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF414 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs1064010 - p.Pro77Ser
rs8100431 - p.Gln65Arg

Additional dbSNP identifiers (rs#s) for ZNF414 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF414 Gene

Variant ID Type Subtype PubMed ID
dgv137n111 CNV deletion 26073780
dgv396n27 CNV loss 19166990
dgv6258n54 CNV loss 21841781
nsv458350 CNV loss 19166990
nsv578559 CNV loss 21841781
nsv953966 CNV deletion 24416366

Variation tolerance for ZNF414 Gene

Gene Damage Index Score: 10.24; 90.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF414 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF414

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF414 Gene

Disorders for ZNF414 Gene

No disorders were found for ZNF414 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF414 Gene

Publications for ZNF414 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations. (PMID: 31515488) Fragoza R … Yu H (Nature communications 2019) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Search for KPNA7 cargo proteins in human cells reveals MVP and ZNF414 as novel regulators of cancer cell growth. (PMID: 27664836) Vuorinen EM … Kallioniemi A (Biochimica et biophysica acta. Molecular basis of disease 2017) 3

Products for ZNF414 Gene

Sources for ZNF414 Gene