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Aliases for ZNF410 Gene

Aliases for ZNF410 Gene

  • Zinc Finger Protein 410 2 3 5
  • Another Partner For ARF 1 3 4
  • Zinc Finger Protein APA-1 3 4
  • APA1 3 4
  • Clones 23667 And 23775 Zinc Finger Protein 3
  • APA-1 3

External Ids for ZNF410 Gene

Previous GeneCards Identifiers for ZNF410 Gene

  • GC14P072344
  • GC14P072345
  • GC14P073423
  • GC14P074353
  • GC14P054520

Summaries for ZNF410 Gene

GeneCards Summary for ZNF410 Gene

ZNF410 (Zinc Finger Protein 410) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZXDB.

UniProtKB/Swiss-Prot for ZNF410 Gene

  • Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.

Additional gene information for ZNF410 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF410 Gene

Genomics for ZNF410 Gene

GeneHancer (GH) Regulatory Elements for ZNF410 Gene

Promoters and enhancers for ZNF410 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I073885 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.9 859 4.3 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B ENSG00000273711 PIR36223 ZNF410 PTGR2 LOC100506476 ENSG00000223300 DCAF4 PNMA1 FAM161B LIN52
GH14I074083 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 43.1 +198.3 198296 3.5 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 LIN52 ALDH6A1 PIR52311 ZNF410 LOC100506476 ELMSAN1 MLH3 YLPM1 FCF1 PTGR2
GH14I073748 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 33.4 -129.0 -128989 17.4 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 ELMSAN1 GC14P073756 MIR4505 ZNF410 PNMA1 RBM25 LOC100506476 NUMB FCF1 PTGR2
GH14I074762 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 42.1 +877.6 877623 3.8 HDGF SMAD1 ARNT ZFP64 NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B YY1 YLPM1 ZNF410 ELMSAN1 MLH3 TTLL5 RPS6KL1 ENSG00000258559 ENSG00000258891 NEK9 ABCD4
GH14I073782 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 33.9 -99.5 -99532 9.2 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 LOC100506476 ELMSAN1 GC14P073786 ZNF410 RBM25 PTGR2 LOC100420966 DCAF4 YLPM1 ENSG00000258559
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF410 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF410 gene promoter:

Genomic Locations for ZNF410 Gene

Genomic Locations for ZNF410 Gene
chr14:73,886,615-73,932,511
(GRCh38/hg38)
Size:
45,897 bases
Orientation:
Plus strand
chr14:74,353,318-74,399,214
(GRCh37/hg19)

Genomic View for ZNF410 Gene

Genes around ZNF410 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF410 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF410 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF410 Gene

Proteins for ZNF410 Gene

  • Protein details for ZNF410 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VK4-ZN410_HUMAN
    Recommended name:
    Zinc finger protein 410
    Protein Accession:
    Q86VK4
    Secondary Accessions:
    • B4DDV5
    • B4DR78
    • O00153
    • Q9BQ19

    Protein attributes for ZNF410 Gene

    Size:
    478 amino acids
    Molecular mass:
    52113 Da
    Quaternary structure:
    • Interacts with CDKN2A/p14ARF.

    Alternative splice isoforms for ZNF410 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF410 Gene

Post-translational modifications for ZNF410 Gene

  • Sumoylated. Sumoylation increases its half-life, possibly by blocking ubiquitin-mediated degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF410 Gene

Domains & Families for ZNF410 Gene

Gene Families for ZNF410 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF410 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF410: view

No data available for UniProtKB/Swiss-Prot for ZNF410 Gene

Function for ZNF410 Gene

Molecular function for ZNF410 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that activates transcription of matrix-remodeling genes such as MMP1 during fibroblast senescence.
UniProtKB/Swiss-Prot Induction:
During fibroblast senescence.

Phenotypes From GWAS Catalog for ZNF410 Gene

Gene Ontology (GO) - Molecular Function for ZNF410 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF410: view

Phenotypes for ZNF410 Gene

genes like me logo Genes that share phenotypes with ZNF410: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF410 Gene

Localization for ZNF410 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF410 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF410 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF410 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF410: view

Pathways & Interactions for ZNF410 Gene

SuperPathways for ZNF410 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF410 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF410: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF410 Gene

Drugs & Compounds for ZNF410 Gene

No Compound Related Data Available

Transcripts for ZNF410 Gene

Unigene Clusters for ZNF410 Gene

Zinc finger protein 410:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF410 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a · 10b · 10c · 10d ·
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - - - - - - -
SP6:
SP7:
SP8: - - - - - -
SP9: - - -
SP10: - - - -
SP11: - - - - - -
SP12: - - -
SP13: - - - - -
SP14: - - -
SP15: - -
SP16: - - - -
SP17: - - - - - - - - - - - - - - - - -
SP18: -
SP19:
SP20: - - - - - - - - - - - -
SP21: - - - - - - - -
SP22:
SP23: - - - - - - - -
SP24:
SP25:

ExUns: 10e · 10f ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c · 16d ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20a · 20b · 20c
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - - - -
SP4:
SP5:
SP6: - -
SP7: - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: - - - - - - - - - - - - - - -
SP18:
SP19:
SP20:
SP21:
SP22: - -
SP23:
SP24: - - - - - -
SP25: - - -

Relevant External Links for ZNF410 Gene

GeneLoc Exon Structure for
ZNF410
ECgene alternative splicing isoforms for
ZNF410

Expression for ZNF410 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF410 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF410 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF410 Gene:

ZNF410

SOURCE GeneReport for Unigene cluster for ZNF410 Gene:

Hs.270869

mRNA Expression by UniProt/SwissProt for ZNF410 Gene:

Q86VK4-ZN410_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for ZNF410 Gene

  • Nervous system(4.9)
  • Lung(4.6)
  • Blood(2.5)
genes like me logo Genes that share expression patterns with ZNF410: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF410 Gene

Orthologs for ZNF410 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF410 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF410 33 34
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia ZNF410 33 34
  • 94.35 (n)
cow
(Bos Taurus)
Mammalia ZNF410 33 34
  • 93.93 (n)
mouse
(Mus musculus)
Mammalia Zfp410 33 16 34
  • 91.28 (n)
rat
(Rattus norvegicus)
Mammalia Zfp410 33
  • 91.14 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF410 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF410 33 34
  • 80.68 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF410 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf410 33
  • 67.99 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16594 33
zebrafish
(Danio rerio)
Actinopterygii znf410 33 34
  • 63.43 (n)
Dr.14332 33
Species where no ortholog for ZNF410 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF410 Gene

ENSEMBL:
Gene Tree for ZNF410 (if available)
TreeFam:
Gene Tree for ZNF410 (if available)

Paralogs for ZNF410 Gene

Paralogs for ZNF410 Gene

Pseudogenes.org Pseudogenes for ZNF410 Gene

genes like me logo Genes that share paralogs with ZNF410: view

Variants for ZNF410 Gene

Sequence variations from dbSNP and Humsavar for ZNF410 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000032322 -- 73,914,924(+) G/A intron_variant
rs1000102421 -- 73,910,384(+) T/C intron_variant
rs1000104317 -- 73,901,997(+) A/C/G intron_variant
rs1000221862 -- 73,897,299(+) T/G intron_variant
rs1000307244 -- 73,910,057(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF410 Gene

Variant ID Type Subtype PubMed ID
dgv663e212 CNV loss 25503493
esv3634923 CNV loss 21293372
esv3634924 CNV loss 21293372
nsv1035460 CNV gain 25217958
nsv1053281 CNV gain 25217958
nsv1116033 CNV deletion 24896259
nsv826992 CNV loss 20364138
nsv826993 CNV loss 20364138

Variation tolerance for ZNF410 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.31% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF410 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF410

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF410 Gene

Disorders for ZNF410 Gene

Additional Disease Information for ZNF410

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF410 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF410 Gene

Publications for ZNF410 Gene

  1. Induction of extracellular matrix-remodeling genes by the senescence-associated protein APA-1. (PMID: 12370286) Benanti JA … Galloway DA (Molecular and cellular biology 2002) 2 3 4 22 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W … Gibbs RA (Genome research 1997) 3 4 58
  5. [Apa1 VDR polymorphism and osteoporosis risk in postmenopausal Mexican women]. (PMID: 26290023) Castelán-Martínez OD … Clark P (Gaceta medica de Mexico 2015) 3 58

Products for ZNF410 Gene

Sources for ZNF410 Gene

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