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This gene encodes a zinc finger protein whose exact function is not known. It may be involved in transcriptional regulation. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
ZNF407 (Zinc Finger Protein 407) is a Protein Coding gene. Diseases associated with ZNF407 include Radioulnar Synostosis-Microcephaly-Scoliosis Syndrome and Non-Syndromic Intellectual Disability. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is GZF1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003676 | nucleic acid binding | IEA | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0008270 | zinc ion binding | IEA | -- |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005634 | nucleus | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0010468 | regulation of gene expression | IBA | 21873635 |
GO:0045944 | positive regulation of transcription by RNA polymerase II | IBA | 21873635 |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | ZNF407 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | ZNF407 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Zfp407 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Zfp407 30 |
|
||
Cow (Bos Taurus) |
Mammalia | ZNF407 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | ZNF407 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | ZNF407 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | ZNF407 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | ZNF407 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | znf407 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ZNF407 31 |
|
OneToOne | |
LOC101884678 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | CG31612 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1022719683 | Uncertain Significance: not specified | 75,064,473(+) |
C/T NM_017757.2(ZNF407):c.*5C>T |
THREE_PRIME_UTR | |
rs112161706 | Benign: not provided | 75,063,970(+) |
C/T NM_017757.2(ZNF407):c.6249C>T (p.Val2083=) |
SYNONYMOUS | |
rs114095914 | Benign: not provided | 74,635,591(+) |
T/G NM_017757.2(ZNF407):c.4572T>G (p.Thr1524=) |
SYNONYMOUS | |
rs114313623 | Benign: not provided | 74,632,254(+) |
C/T NM_017757.2(ZNF407):c.1235C>T (p.Ser412Leu) |
MISSENSE | |
rs115368653 | Benign: not provided | 74,632,046(+) |
G/A NM_017757.2(ZNF407):c.1027G>A (p.Glu343Lys) |
MISSENSE |
Disorder | Aliases | PubMed IDs |
---|---|---|
radioulnar synostosis-microcephaly-scoliosis syndrome |
|
|
non-syndromic intellectual disability |
|
|
homocarnosinosis |
|
|
syndromic intellectual disability |
|
|
radioulnar synostosis |
|
|