This gene encodes a zinc finger protein whose exact function is not known. It may be involved in transcriptional regulation. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] See more...

Aliases for ZNF407 Gene

Aliases for ZNF407 Gene

  • Zinc Finger Protein 407 2 3 4 5
  • KIAA1703 2 4
  • FLJ20307 2
  • FLJ13839 2
  • ZNF407 5

External Ids for ZNF407 Gene

Previous GeneCards Identifiers for ZNF407 Gene

  • GC18P072345
  • GC18P072108
  • GC18P070472
  • GC18P070474
  • GC18P069029

Summaries for ZNF407 Gene

Entrez Gene Summary for ZNF407 Gene

  • This gene encodes a zinc finger protein whose exact function is not known. It may be involved in transcriptional regulation. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for ZNF407 Gene

ZNF407 (Zinc Finger Protein 407) is a Protein Coding gene. Diseases associated with ZNF407 include Radioulnar Synostosis-Microcephaly-Scoliosis Syndrome and Non-Syndromic Intellectual Disability. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF572.

UniProtKB/Swiss-Prot Summary for ZNF407 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF407 Gene

Genomics for ZNF407 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF407 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J074595 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 614.6 +6.8 6770 4.4 SP1 HNRNPL REST NFKBIZ LARP7 GABPA DDX20 ZNF143 ZIC2 RBFOX2 LINC00909 ZNF407 piR-56640-011 lnc-ZNF407-1 ZADH2
GH18J074591 Enhancer 0.3 FANTOM5 602 +0.6 608 0.4 MAFK ZNF407 lnc-ZNF407-1 LINC00909 CNDP2 CNDP1 ZADH2
GH18J075198 Promoter/Enhancer 3.1 UCNEbase EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 33.8 +619.4 619425 24.2 SP1 HNRNPL CREB1 GATAD2A PRDM10 REST ZNF629 RFX1 LEF1 IKZF1 ZADH2 TSHZ1 ZNF407 piR-55315
GH18J074289 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 25.9 -299.1 -299091 3.4 SP1 HNRNPL CREB1 GATAD2A PRDM10 REST TFE3 NFKBIZ KDM1A RCOR2 CYB5A ENSG00000286529 lnc-FBXO15-6 ZNF407 C18orf63 lnc-CYB5A-2 ENSG00000260569 TIMM21
GH18J074495 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 23.4 -91.7 -91659 7.6 SP1 CREB1 ATF7 PRDM10 ZNF629 RFX1 IKZF1 NFKBIZ ZNF692 POLR2A CNDP2 ZNF407 CNDP1 FAUP1 ENSG00000276934
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF407 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF407

Top Transcription factor binding sites by QIAGEN in the ZNF407 gene promoter:
  • c-Myc
  • FOXI1
  • HFH-3
  • HOXA9
  • Max1
  • Olf-1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)
  • S8

Genomic Locations for ZNF407 Gene

Genomic Locations for ZNF407 Gene
chr18:74,590,475-75,065,672
(GRCh38/hg38)
Size:
475,198 bases
Orientation:
Plus strand
chr18:72,265,106-72,777,628
(GRCh37/hg19)
Size:
512,523 bases
Orientation:
Plus strand

Genomic View for ZNF407 Gene

Genes around ZNF407 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF407 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF407 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF407 Gene

Proteins for ZNF407 Gene

  • Protein details for ZNF407 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0G0-ZN407_HUMAN
    Recommended name:
    Zinc finger protein 407
    Protein Accession:
    Q9C0G0
    Secondary Accessions:
    • B5MD54
    • Q96MY0
    • Q9H8A1
    • Q9NXD4
    • Q9NXD7

    Protein attributes for ZNF407 Gene

    Size:
    2248 amino acids
    Molecular mass:
    247367 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91077.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91080.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF407 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF407 Gene

Post-translational modifications for ZNF407 Gene

  • Ubiquitination at Lys1364
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ZNF407 Gene

Domains & Families for ZNF407 Gene

Gene Families for ZNF407 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF407 Gene

Suggested Antigen Peptide Sequences for ZNF407 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 407 (ZN407_HUMAN)
genes like me logo Genes that share domains with ZNF407: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF407 Gene

Function for ZNF407 Gene

Molecular function for ZNF407 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF407 Gene

Gene Ontology (GO) - Molecular Function for ZNF407 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF407: view
genes like me logo Genes that share phenotypes with ZNF407: view

Animal Model Products

CRISPR Products

miRNA for ZNF407 Gene

miRTarBase miRNAs that target ZNF407

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF407

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF407 Gene

Localization for ZNF407 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF407 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF407 gene
Compartment Confidence
nucleus 4
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF407 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF407: view

Pathways & Interactions for ZNF407 Gene

PathCards logo

SuperPathways for ZNF407 Gene

No Data Available

Interacting Proteins for ZNF407 Gene

Gene Ontology (GO) - Biological Process for ZNF407 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010468 regulation of gene expression IBA 21873635
genes like me logo Genes that share ontologies with ZNF407: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF407 Gene

Drugs & Compounds for ZNF407 Gene

No Compound Related Data Available

Transcripts for ZNF407 Gene

mRNA/cDNA for ZNF407 Gene

4 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF407

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF407 Gene

No ASD Table

Relevant External Links for ZNF407 Gene

GeneLoc Exon Structure for
ZNF407

Expression for ZNF407 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF407 Gene

Protein differential expression in normal tissues from HIPED for ZNF407 Gene

This gene is overexpressed in Fetal heart (39.5), Heart (14.4), and Skin (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF407 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF407

SOURCE GeneReport for Unigene cluster for ZNF407 Gene:

Hs.536490

Evidence on tissue expression from TISSUES for ZNF407 Gene

  • Nervous system(4.3)
  • Liver(4.3)
  • Thyroid gland(4.1)
genes like me logo Genes that share expression patterns with ZNF407: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF407 Gene

Orthologs for ZNF407 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF407 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF407 30 31
  • 99.21 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF407 30 31
  • 81.5 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp407 30 17 31
  • 79.23 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp407 30
  • 78.83 (n)
Cow
(Bos Taurus)
Mammalia ZNF407 30 31
  • 76.98 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF407 31
  • 64 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia ZNF407 31
  • 53 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZNF407 30 31
  • 64.52 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZNF407 31
  • 46 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia znf407 30
  • 63.5 (n)
Zebrafish
(Danio rerio)
Actinopterygii ZNF407 31
  • 67 (a)
OneToOne
LOC101884678 30
  • 62.99 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG31612 31
  • 10 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 19 (a)
OneToOne
Species where no ortholog for ZNF407 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF407 Gene

ENSEMBL:
Gene Tree for ZNF407 (if available)
TreeFam:
Gene Tree for ZNF407 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF407: view image

Paralogs for ZNF407 Gene

genes like me logo Genes that share paralogs with ZNF407: view

Variants for ZNF407 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF407 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
684726 Uncertain Significance: Radioulnar synostosis-microcephaly-scoliosis syndrome 74,781,472(+) G/T MISSENSE_VARIANT
689344 Uncertain Significance: not provided 74,633,444(+) T/C MISSENSE_VARIANT
689353 Uncertain Significance: not provided 74,634,661(+) G/C MISSENSE_VARIANT
689354 Uncertain Significance: not provided 74,633,903(+) C/G MISSENSE_VARIANT
708267 Benign: not provided 75,064,000(+) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF407 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF407 Gene

Variant ID Type Subtype PubMed ID
esv1570874 CNV deletion 17803354
esv2034794 CNV deletion 18987734
esv2053114 CNV deletion 18987734
esv2521516 CNV deletion 19546169
esv2561068 CNV deletion 19546169
esv2612943 CNV deletion 19546169
esv2657517 CNV deletion 23128226
esv2665165 CNV deletion 23128226
esv2673740 CNV deletion 23128226
esv2675767 CNV deletion 23128226
esv2717349 CNV deletion 23290073
esv2717350 CNV deletion 23290073
esv2717352 CNV deletion 23290073
esv2717353 CNV deletion 23290073
esv2717354 CNV deletion 23290073
esv2717355 CNV deletion 23290073
esv3336811 CNV duplication 20981092
esv3336831 CNV insertion 20981092
esv3450633 CNV insertion 20981092
esv3555663 CNV deletion 23714750
esv3583152 CNV loss 25503493
esv3583153 CNV loss 25503493
esv3643123 CNV loss 21293372
esv3643124 CNV gain 21293372
esv3643125 CNV loss 21293372
esv3643126 CNV loss 21293372
esv3643127 CNV loss 21293372
esv3643129 CNV loss 21293372
esv3643130 CNV loss 21293372
esv3643131 CNV loss 21293372
esv4223 CNV loss 18987735
esv999235 CNV deletion 20482838
nsv1057441 CNV gain 25217958
nsv1058948 CNV gain 25217958
nsv1062693 CNV gain 25217958
nsv1072276 CNV deletion 25765185
nsv1072811 CNV deletion 25765185
nsv1111963 CNV deletion 24896259
nsv1112301 CNV deletion 24896259
nsv1113938 CNV deletion 24896259
nsv1117200 CNV tandem duplication 24896259
nsv1120732 CNV deletion 24896259
nsv1121537 CNV deletion 24896259
nsv1127637 CNV deletion 24896259
nsv2357 CNV insertion 18451855
nsv2358 CNV insertion 18451855
nsv2359 CNV deletion 18451855
nsv2360 CNV deletion 18451855
nsv474058 CNV novel sequence insertion 20440878
nsv477235 CNV novel sequence insertion 20440878
nsv479523 CNV novel sequence insertion 20440878
nsv516801 CNV loss 19592680
nsv518563 CNV gain 19592680
nsv523996 CNV gain 19592680
nsv577656 CNV gain 21841781

Variation tolerance for ZNF407 Gene

Residual Variation Intolerance Score: 9.42% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.52; 55.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF407 Gene

Human Gene Mutation Database (HGMD)
ZNF407
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF407

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF407 Gene

Disorders for ZNF407 Gene

MalaCards: The human disease database

(7) MalaCards diseases for ZNF407 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
radioulnar synostosis-microcephaly-scoliosis syndrome
  • tsukahara syndrome
non-syndromic intellectual disability
homocarnosinosis
  • homocarnosinase deficiency
syndromic intellectual disability
radioulnar synostosis
  • congenital radioulnar synostosis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF407

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZNF407: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF407 Gene

Publications for ZNF407 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  4. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PMID: 19690890) McDonough CW … Bowden DW (Human genetics 2009) 3 41
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4

Products for ZNF407 Gene

Sources for ZNF407 Gene