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Aliases for ZNF404 Gene

Aliases for ZNF404 Gene

  • Zinc Finger Protein 404 2 3 5

External Ids for ZNF404 Gene

Previous GeneCards Identifiers for ZNF404 Gene

  • GC19U900013
  • GC19M049030
  • GC19M049068
  • GC19M044376
  • GC19M040808

Summaries for ZNF404 Gene

GeneCards Summary for ZNF404 Gene

ZNF404 (Zinc Finger Protein 404) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF470.

UniProtKB/Swiss-Prot for ZNF404 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF404 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF404 Gene

Genomics for ZNF404 Gene

GeneHancer (GH) Regulatory Elements for ZNF404 Gene

Promoters and enhancers for ZNF404 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I043901 Promoter/Enhancer 1.5 Ensembl ENCODE 609.5 -0.4 -416 1.6 ARID4B ZNF2 YY1 ZNF766 ZNF302 ZNF416 ZNF143 ZNF548 KLF13 SP3 ZNF404 LOC100505715 ENSG00000267191 ZNF45 ZNF180 ZNF225 ZNF224 ZNF227 ZNF284 ZNF234
GH19I043883 Promoter 0.5 EPDnew 550.4 +17.4 17411 0.1 ZNF404 ZNF45 ENSG00000278917 ZNF283
GH19I043826 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 18.6 +73.9 73911 1.6 ATF1 ZNF493 ARID4B SIN3A DMAP1 YY1 ETS1 ZNF121 ZNF766 ELK1 ZNF283 LYPD5 ZNF45 ZNF225 ZNF180 ZNF234 MRPS15P2 ZNF224 ZNF227 ZNF155
GH19I043673 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 20.5 +226.5 226535 3 PKNOX1 ATF1 ZNF133 SIN3A YBX1 ZNF2 ZBTB7B ZNF48 ZNF121 ZNF143 ZNF225 ZNF283 ZNF45 PLAUR ZNF180 ZNF226 ZNF112 ZNF234 ZNF223 ZNF224
GH19I044740 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.6 -848.6 -848632 19.4 YBX1 FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 SP3 BCL3 ZNF45 ZNF224 ZNF155 ZNF180 ZNF284 ZNF225 ZNF234 CLASRP ZNF235
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF404 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF404 Gene

Genomic Locations for ZNF404 Gene
29,023 bases
Minus strand

Genomic View for ZNF404 Gene

Genes around ZNF404 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF404 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF404 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF404 Gene

Proteins for ZNF404 Gene

  • Protein details for ZNF404 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 404
    Protein Accession:
    Secondary Accessions:
    • A4FU30
    • K7ELF2

    Protein attributes for ZNF404 Gene

    552 amino acids
    Molecular mass:
    65425 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF404 Gene

Post-translational modifications for ZNF404 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF404 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF404 Gene

Domains & Families for ZNF404 Gene

Gene Families for ZNF404 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF404 Gene

Suggested Antigen Peptide Sequences for ZNF404 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF404: view

Function for ZNF404 Gene

Molecular function for ZNF404 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF404 Gene

Gene Ontology (GO) - Molecular Function for ZNF404 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF404: view

Phenotypes for ZNF404 Gene

genes like me logo Genes that share phenotypes with ZNF404: view

miRNA for ZNF404 Gene

miRTarBase miRNAs that target ZNF404

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF404 Gene

Localization for ZNF404 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF404 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF404 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF404 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF404: view

Pathways & Interactions for ZNF404 Gene

SuperPathways for ZNF404 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF404 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF404: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF404 Gene

Drugs & Compounds for ZNF404 Gene

No Compound Related Data Available

Transcripts for ZNF404 Gene

mRNA/cDNA for ZNF404 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(18) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF404 Gene

Zinc finger protein 404:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF404 Gene

No ASD Table

Relevant External Links for ZNF404 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF404 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF404 Gene

Protein differential expression in normal tissues from HIPED for ZNF404 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF404 Gene

Protein tissue co-expression partners for ZNF404 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF404 Gene:


SOURCE GeneReport for Unigene cluster for ZNF404 Gene:

genes like me logo Genes that share expression patterns with ZNF404: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF404 Gene

Orthologs for ZNF404 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF404 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF404 33 34
  • 99.03 (n)
(Canis familiaris)
Mammalia ZNF404 33 34
  • 91.06 (n)
(Bos Taurus)
Mammalia ZNF404 33
  • 87.14 (n)
ZNF383 34
  • 43 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 41 (a)
Species where no ortholog for ZNF404 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF404 Gene

Gene Tree for ZNF404 (if available)
Gene Tree for ZNF404 (if available)

Paralogs for ZNF404 Gene

(484) SIMAP similar genes for ZNF404 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF404: view

Variants for ZNF404 Gene

Sequence variations from dbSNP and Humsavar for ZNF404 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000214616 -- 43,880,670(-) G/A intron_variant
rs1000632499 -- 43,882,287(-) C/T intron_variant
rs1000660408 -- 43,881,900(-) T/G intron_variant
rs1001015665 -- 43,885,889(-) T/C upstream_transcript_variant
rs1001186144 -- 43,875,005(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF404 Gene

Variant ID Type Subtype PubMed ID
esv3303886 CNV mobile element insertion 20981092
esv3405915 CNV insertion 20981092
nsv458710 CNV loss 19166990
nsv579853 CNV loss 21841781

Variation tolerance for ZNF404 Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.45; 96.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF404 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF404 Gene

Disorders for ZNF404 Gene

Additional Disease Information for ZNF404

No disorders were found for ZNF404 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF404 Gene

Publications for ZNF404 Gene

  1. Identification of breast cancer associated variants that modulate transcription factor binding. (PMID: 28957321) Liu Y … Guertin MJ (PLoS genetics 2017) 3 58
  2. F-box only protein 9 is an E3 ubiquitin ligase of PPARγ. (PMID: 27197753) Lee KW … Park KS (Experimental & molecular medicine 2016) 3 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. The correlation between reading and mathematics ability at age twelve has a substantial genetic component. (PMID: 25003214) Davis OS … Spencer CC (Nature communications 2014) 3 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for ZNF404 Gene

Sources for ZNF404 Gene

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