Aliases for ZNF404 Gene

Aliases for ZNF404 Gene

  • Zinc Finger Protein 404 2 3 4 5

External Ids for ZNF404 Gene

Previous GeneCards Identifiers for ZNF404 Gene

  • GC19U900013
  • GC19M049030
  • GC19M049068
  • GC19M044376
  • GC19M040808

Summaries for ZNF404 Gene

GeneCards Summary for ZNF404 Gene

ZNF404 (Zinc Finger Protein 404) is a Protein Coding gene. Diseases associated with ZNF404 include Deafness, Autosomal Recessive 29 and Zellweger Syndrome. Among its related pathways are Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF529.

UniProtKB/Swiss-Prot Summary for ZNF404 Gene

Additional gene information for ZNF404 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF404 Gene

Genomics for ZNF404 Gene

GeneHancer (GH) Regulatory Elements for ZNF404 Gene

Promoters and enhancers for ZNF404 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF404 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF404

Genomic Locations for ZNF404 Gene

Genomic Locations for ZNF404 Gene
chr19:43,872,363-43,901,385
(GRCh38/hg38)
Size:
29,023 bases
Orientation:
Minus strand
chr19:44,376,515-44,405,537
(GRCh37/hg19)
Size:
29,023 bases
Orientation:
Minus strand

Genomic View for ZNF404 Gene

Genes around ZNF404 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF404 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF404 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF404 Gene

Proteins for ZNF404 Gene

  • Protein details for ZNF404 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q494X3-ZN404_HUMAN
    Recommended name:
    Zinc finger protein 404
    Protein Accession:
    Q494X3
    Secondary Accessions:
    • A4FU30
    • K7ELF2

    Protein attributes for ZNF404 Gene

    Size:
    552 amino acids
    Molecular mass:
    65425 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF404 Gene

Post-translational modifications for ZNF404 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF404 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF404 Gene

Domains & Families for ZNF404 Gene

Gene Families for ZNF404 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF404 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF404 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein LOC163141 (Q86WM5_HUMAN)
  • Zinc finger protein 404 (ZN404_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q494X3

UniProtKB/Swiss-Prot:

ZN404_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF404: view

Function for ZNF404 Gene

Molecular function for ZNF404 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF404 Gene

Gene Ontology (GO) - Molecular Function for ZNF404 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF404: view
genes like me logo Genes that share phenotypes with ZNF404: view

miRNA for ZNF404 Gene

miRTarBase miRNAs that target ZNF404

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF404 Gene

Localization for ZNF404 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF404 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF404 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF404 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF404: view

Pathways & Interactions for ZNF404 Gene

PathCards logo

SuperPathways for ZNF404 Gene

genes like me logo Genes that share pathways with ZNF404: view

Pathways by source for ZNF404 Gene

1 KEGG pathway for ZNF404 Gene

Interacting Proteins for ZNF404 Gene

;

Gene Ontology (GO) - Biological Process for ZNF404 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF404: view

No data available for SIGNOR curated interactions for ZNF404 Gene

Drugs & Compounds for ZNF404 Gene

No Compound Related Data Available

Transcripts for ZNF404 Gene

mRNA/cDNA for ZNF404 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF404 Gene

No ASD Table

Relevant External Links for ZNF404 Gene

GeneLoc Exon Structure for
ZNF404

Expression for ZNF404 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF404 Gene

Protein differential expression in normal tissues from HIPED for ZNF404 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF404 Gene



Protein tissue co-expression partners for ZNF404 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF404

SOURCE GeneReport for Unigene cluster for ZNF404 Gene:

Hs.76561
genes like me logo Genes that share expression patterns with ZNF404: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF404 Gene

Orthologs for ZNF404 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF404 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF404 31 30
  • 99.03 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF404 31 30
  • 91.06 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF404 30
  • 87.14 (n)
ZNF383 31
  • 43 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 41 (a)
OneToMany
Species where no ortholog for ZNF404 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF404 Gene

ENSEMBL:
Gene Tree for ZNF404 (if available)
TreeFam:
Gene Tree for ZNF404 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF404: view image

Paralogs for ZNF404 Gene

(484) SIMAP similar genes for ZNF404 Gene using alignment to 2 proteins:

  • ZN404_HUMAN
  • Q86WM5_HUMAN
genes like me logo Genes that share paralogs with ZNF404: view

Variants for ZNF404 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF404 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
777497 Likely Benign: not provided 43,873,839(-) G/A SYNONYMOUS_VARIANT
784400 Benign: not provided 43,874,084(-) G/T INTRON_VARIANT
rs12977303 - p.His233Tyr
rs239942 - p.Gly337Ser

Additional dbSNP identifiers (rs#s) for ZNF404 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF404 Gene

Variant ID Type Subtype PubMed ID
esv3303886 CNV mobile element insertion 20981092
esv3405915 CNV insertion 20981092
nsv458710 CNV loss 19166990
nsv579853 CNV loss 21841781

Variation tolerance for ZNF404 Gene

Residual Variation Intolerance Score: 89.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.45; 96.41% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF404 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF404

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF404 Gene

Disorders for ZNF404 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF404 Gene - From: DISEASES

Disorder Aliases PubMed IDs
deafness, autosomal recessive 29
  • dfnb29
zellweger syndrome
  • zs
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF404

genes like me logo Genes that share disorders with ZNF404: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF404 Gene

Publications for ZNF404 Gene

  1. Identification of breast cancer associated variants that modulate transcription factor binding. (PMID: 28957321) Liu Y … Guertin MJ (PLoS genetics 2017) 3 54
  2. Computational Analysis of Breast Cancer GWAS Loci Identifies the Putative Deleterious Effect of STXBP4 and ZNF404 Gene Variants. (PMID: 28422318) Masoodi TA … Shaik NA (Journal of cellular biochemistry 2017) 3 54
  3. F-box only protein 9 is an E3 ubiquitin ligase of PPARγ. (PMID: 27197753) Lee KW … Park KS (Experimental & molecular medicine 2016) 3 54
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 54
  5. The correlation between reading and mathematics ability at age twelve has a substantial genetic component. (PMID: 25003214) Davis OS … Spencer CC (Nature communications 2014) 3 54

Products for ZNF404 Gene

Sources for ZNF404 Gene