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Aliases for ZNF398 Gene

Aliases for ZNF398 Gene

  • Zinc Finger Protein 398 2 3 3 5
  • ZER6 3 4
  • Zinc Finger-Estrogen Receptor Interaction, Clone 6 3
  • Zinc Finger DNA Binding Protein P52/P71 3
  • Zinc Finger DNA-Binding Protein P52/P71 4
  • Zinc Finger DNA Binding Protein ZER6 3
  • KIAA1339 4
  • P51 3
  • P71 3

External Ids for ZNF398 Gene

Previous GeneCards Identifiers for ZNF398 Gene

  • GC07P147070
  • GC07P148138
  • GC07P148215
  • GC07P148261
  • GC07P148454
  • GC07P148787
  • GC07P142900

Summaries for ZNF398 Gene

Entrez Gene Summary for ZNF398 Gene

  • This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. The encoded protein acts as a transcriptional activator. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described, but their full length sequence has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF398 Gene

ZNF398 (Zinc Finger Protein 398) is a Protein Coding gene. Diseases associated with ZNF398 include Aleutian Mink Disease. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF282.

UniProtKB/Swiss-Prot for ZNF398 Gene

  • Function as a transcriptional activator.

Additional gene information for ZNF398 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF398 Gene

Genomics for ZNF398 Gene

GeneHancer (GH) Regulatory Elements for ZNF398 Gene

Promoters and enhancers for ZNF398 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J149143 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 702.9 +20.1 20108 7 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A ZNF2 YY1 POLR2B ZNF398 ZNF425 GC07P149147 GC07P149148 ZNF783 ZNF282 ZNF212 ENSG00000271664 LOC155060 ZNF767P
GH07J149124 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 705.8 +0.4 410 3.8 CLOCK MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZFP41 ZNF398 ZNF425 GC07M149126 RN7SL521P ZNF786 ZNF212 ZNF783 ENSG00000271664 ZNF282 ZNF767P
GH07J148940 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 79.3 -185.0 -185015 2.8 PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B EZH2 GC07P148942 RNY5 ZNF398 ZNF783 ZNF777 ENSG00000271664 ZNF212 ZNF767P LOC155060
GH07J148697 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 54 -427.0 -426954 4.6 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B CUL1 ENSG00000273314 GC07M148697 GC07M148698 ZNF212 ZNF398 ZNF783 ENSG00000271664 ZNF282 ZNF767P
GH07J148882 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 50.2 -242.6 -242569 3.6 HNRNPUL1 PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B GC07P148885 EZH2 ZNF783 ZNF398 ENSG00000271664 ZNF212 ZNF282 ZNF767P LOC155060 ZNF777
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF398 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF398 gene promoter:
  • Nkx2-5
  • GATA-3
  • GATA-2
  • GATA-1
  • MIF-1
  • C/EBPbeta
  • Pax-3
  • Ik-2
  • Msx-1
  • XBP-1

Genomic Locations for ZNF398 Gene

Genomic Locations for ZNF398 Gene
chr7:149,126,416-149,183,042
(GRCh38/hg38)
Size:
56,627 bases
Orientation:
Plus strand
chr7:148,823,508-148,880,134
(GRCh37/hg19)
Size:
56,627 bases
Orientation:
Plus strand

Genomic View for ZNF398 Gene

Genes around ZNF398 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF398 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF398 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF398 Gene

Proteins for ZNF398 Gene

  • Protein details for ZNF398 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD17-ZN398_HUMAN
    Recommended name:
    Zinc finger protein 398
    Protein Accession:
    Q8TD17
    Secondary Accessions:
    • A8K384
    • B4E377
    • Q8TD18
    • Q9P2K7
    • Q9UDV8

    Protein attributes for ZNF398 Gene

    Size:
    642 amino acids
    Molecular mass:
    71311 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF398 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF398 Gene

Post-translational modifications for ZNF398 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF398 Gene

No data available for DME Specific Peptides for ZNF398 Gene

Domains & Families for ZNF398 Gene

Gene Families for ZNF398 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF398 Gene

Suggested Antigen Peptide Sequences for ZNF398 Gene

Graphical View of Domain Structure for InterPro Entry

Q8TD17

UniProtKB/Swiss-Prot:

ZN398_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF398: view

Function for ZNF398 Gene

Molecular function for ZNF398 Gene

UniProtKB/Swiss-Prot Function:
Function as a transcriptional activator.
UniProtKB/Swiss-Prot Induction:
By estrogen receptor alpha.

Phenotypes From GWAS Catalog for ZNF398 Gene

Gene Ontology (GO) - Molecular Function for ZNF398 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 21516116
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF398: view
genes like me logo Genes that share phenotypes with ZNF398: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF398

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF398 Gene

Localization for ZNF398 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF398 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF398 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF398 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus NAS 11779858
genes like me logo Genes that share ontologies with ZNF398: view

Pathways & Interactions for ZNF398 Gene

SuperPathways for ZNF398 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF398: view

Pathways by source for ZNF398 Gene

2 Reactome pathways for ZNF398 Gene

Gene Ontology (GO) - Biological Process for ZNF398 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated NAS 11779858
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0045893 positive regulation of transcription, DNA-templated NAS 11779858
genes like me logo Genes that share ontologies with ZNF398: view

No data available for SIGNOR curated interactions for ZNF398 Gene

Drugs & Compounds for ZNF398 Gene

No Compound Related Data Available

Transcripts for ZNF398 Gene

mRNA/cDNA for ZNF398 Gene

(5) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF398 Gene

Zinc finger protein 398:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF398

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF398 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - - -
SP3:

Relevant External Links for ZNF398 Gene

GeneLoc Exon Structure for
ZNF398
ECgene alternative splicing isoforms for
ZNF398

Expression for ZNF398 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF398 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF398 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF398 Gene



Protein tissue co-expression partners for ZNF398 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF398 Gene:

ZNF398

SOURCE GeneReport for Unigene cluster for ZNF398 Gene:

Hs.632032

Evidence on tissue expression from TISSUES for ZNF398 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF398: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF398 Gene

Orthologs for ZNF398 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF398 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF398 34 33
  • 99.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF398 34 33
  • 89.41 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp398 33
  • 87.44 (n)
mouse
(Mus musculus)
Mammalia Zfp398 16 34 33
  • 87.02 (n)
cow
(Bos Taurus)
Mammalia ZNF398 34 33
  • 84.37 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF398 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 26 (a)
OneToMany
-- 34
  • 18 (a)
OneToMany
chicken
(Gallus gallus)
Aves ZNF767 34
  • 43 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 37 (a)
ManyToMany
Species where no ortholog for ZNF398 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF398 Gene

ENSEMBL:
Gene Tree for ZNF398 (if available)
TreeFam:
Gene Tree for ZNF398 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF398: view image

Paralogs for ZNF398 Gene

Paralogs for ZNF398 Gene

(225) SIMAP similar genes for ZNF398 Gene using alignment to 2 proteins:

  • ZN398_HUMAN
  • B4DXA9_HUMAN
genes like me logo Genes that share paralogs with ZNF398: view

Variants for ZNF398 Gene

Sequence variations from dbSNP and Humsavar for ZNF398 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000032075 -- 149,157,004(+) C/G intron_variant
rs1000048169 -- 149,165,035(+) A/G intron_variant
rs1000049038 -- 149,125,009(+) A/C upstream_transcript_variant
rs1000103072 -- 149,164,699(+) G/A intron_variant
rs1000160732 -- 149,151,358(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF398 Gene

Variant ID Type Subtype PubMed ID
nsv1128375 CNV deletion 24896259
nsv1018754 CNV gain 25217958
esv3615427 CNV loss 21293372
esv3542628 CNV deletion 23714750
esv3542627 CNV deletion 23714750

Variation tolerance for ZNF398 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.53; 64.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF398 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF398

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF398 Gene

Disorders for ZNF398 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF398 Gene - From: DISEASES

Disorder Aliases PubMed IDs
aleutian mink disease
  • aleutian disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF398

genes like me logo Genes that share disorders with ZNF398: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF398 Gene

Publications for ZNF398 Gene

  1. A novel zinc finger transcription factor with two isoforms that are differentially repressed by estrogen receptor-alpha. (PMID: 11779858) Conroy AT … Weigel RJ (The Journal of biological chemistry 2002) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF398 Gene

Sources for ZNF398 Gene

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