This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. The encoded protein acts as a transcriptional activator. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described, but their full length sequence has not been determined. [provided by RefSeq, Jul 200... See more...

Aliases for ZNF398 Gene

Aliases for ZNF398 Gene

  • Zinc Finger Protein 398 2 3 4 5
  • ZER6 2 3 4
  • KIAA1339 2 4
  • P51 2 3
  • P71 2 3
  • Zinc Finger-Estrogen Receptor Interaction, Clone 6 3
  • Zinc Finger DNA Binding Protein P52/P71 3
  • Zinc Finger DNA-Binding Protein P52/P71 4
  • Zinc Finger DNA Binding Protein ZER6 3
  • ZNF398 5

External Ids for ZNF398 Gene

Previous GeneCards Identifiers for ZNF398 Gene

  • GC07P147070
  • GC07P148138
  • GC07P148215
  • GC07P148261
  • GC07P148454
  • GC07P148787
  • GC07P142900

Summaries for ZNF398 Gene

Entrez Gene Summary for ZNF398 Gene

  • This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. The encoded protein acts as a transcriptional activator. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described, but their full length sequence has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF398 Gene

ZNF398 (Zinc Finger Protein 398) is a Protein Coding gene. Diseases associated with ZNF398 include Spinal Canal Intradural Extramedullary Neoplasm and Sagittal Sinus Thrombosis. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF777.

UniProtKB/Swiss-Prot Summary for ZNF398 Gene

Additional gene information for ZNF398 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF398 Gene

Genomics for ZNF398 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF398 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF398 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF398

Top Transcription factor binding sites by QIAGEN in the ZNF398 gene promoter:
  • C/EBPbeta
  • GATA-1
  • GATA-2
  • GATA-3
  • Ik-2
  • MIF-1
  • Msx-1
  • Nkx2-5
  • Pax-3
  • XBP-1

Genomic Locations for ZNF398 Gene

Genomic Locations for ZNF398 Gene
chr7:149,126,408-149,183,042
(GRCh38/hg38)
Size:
56,635 bases
Orientation:
Plus strand
chr7:148,823,508-148,880,134
(GRCh37/hg19)
Size:
56,627 bases
Orientation:
Plus strand

Genomic View for ZNF398 Gene

Genes around ZNF398 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF398 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF398 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF398 Gene

Proteins for ZNF398 Gene

  • Protein details for ZNF398 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD17-ZN398_HUMAN
    Recommended name:
    Zinc finger protein 398
    Protein Accession:
    Q8TD17
    Secondary Accessions:
    • A8K384
    • B4E377
    • Q8TD18
    • Q9P2K7
    • Q9UDV8

    Protein attributes for ZNF398 Gene

    Size:
    642 amino acids
    Molecular mass:
    71311 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF398 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF398 Gene

Post-translational modifications for ZNF398 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF398 Gene

No data available for DME Specific Peptides for ZNF398 Gene

Domains & Families for ZNF398 Gene

Gene Families for ZNF398 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF398 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF398 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59779, highly similar to Zinc finger protein 398 (B4DXA9_HUMAN)
  • Zinc finger DNA-binding protein p52/p71 (ZN398_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TD17

UniProtKB/Swiss-Prot:

ZN398_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF398: view

Function for ZNF398 Gene

Molecular function for ZNF398 Gene

UniProtKB/Swiss-Prot Function:
Functions as a transcriptional activator.
UniProtKB/Swiss-Prot Induction:
By estrogen receptor alpha.

Phenotypes From GWAS Catalog for ZNF398 Gene

Gene Ontology (GO) - Molecular Function for ZNF398 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 21516116
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZNF398: view
genes like me logo Genes that share phenotypes with ZNF398: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF398

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF398 Gene

Localization for ZNF398 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF398 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF398 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF398 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 11779858
genes like me logo Genes that share ontologies with ZNF398: view

Pathways & Interactions for ZNF398 Gene

genes like me logo Genes that share pathways with ZNF398: view

Pathways by source for ZNF398 Gene

2 Reactome pathways for ZNF398 Gene
1 KEGG pathway for ZNF398 Gene

Gene Ontology (GO) - Biological Process for ZNF398 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 11779858
GO:0045893 positive regulation of transcription, DNA-templated NAS 11779858
genes like me logo Genes that share ontologies with ZNF398: view

No data available for SIGNOR curated interactions for ZNF398 Gene

Drugs & Compounds for ZNF398 Gene

No Compound Related Data Available

Transcripts for ZNF398 Gene

mRNA/cDNA for ZNF398 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF398

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF398 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - - -
SP3:

Relevant External Links for ZNF398 Gene

GeneLoc Exon Structure for
ZNF398

Expression for ZNF398 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF398 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF398 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF398 Gene



Protein tissue co-expression partners for ZNF398 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF398

SOURCE GeneReport for Unigene cluster for ZNF398 Gene:

Hs.632032

Evidence on tissue expression from TISSUES for ZNF398 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF398: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF398 Gene

Orthologs for ZNF398 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF398 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF398 30 31
  • 99.69 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF398 30 31
  • 89.41 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp398 30
  • 87.44 (n)
Mouse
(Mus musculus)
Mammalia Zfp398 30 17 31
  • 87.02 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF398 30 31
  • 84.37 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF398 31
  • 76 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 26 (a)
OneToMany
-- 31
  • 18 (a)
OneToMany
Chicken
(Gallus gallus)
Aves ZNF767 31
  • 43 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 37 (a)
ManyToMany
Species where no ortholog for ZNF398 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF398 Gene

ENSEMBL:
Gene Tree for ZNF398 (if available)
TreeFam:
Gene Tree for ZNF398 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF398: view image

Paralogs for ZNF398 Gene

(225) SIMAP similar genes for ZNF398 Gene using alignment to 2 proteins:

  • ZN398_HUMAN
  • B4DXA9_HUMAN
genes like me logo Genes that share paralogs with ZNF398: view

Variants for ZNF398 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF398 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs2240370 - p.Ser294Leu
rs3801979 - p.Glu87Asp

Additional dbSNP identifiers (rs#s) for ZNF398 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF398 Gene

Variant ID Type Subtype PubMed ID
esv3542627 CNV deletion 23714750
esv3542628 CNV deletion 23714750
esv3615427 CNV loss 21293372
nsv1018754 CNV gain 25217958
nsv1128375 CNV deletion 24896259

Variation tolerance for ZNF398 Gene

Residual Variation Intolerance Score: 25.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.53; 64.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF398 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF398

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF398 Gene

Disorders for ZNF398 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ZNF398 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spinal canal intradural extramedullary neoplasm
  • intradural extramedullary spinal tumors
sagittal sinus thrombosis
  • thrombosis of superior longitudinal sinus
intracranial sinus thrombosis
  • sinus thrombosis, intracranial
hypoglycemic coma
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF398: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF398 Gene

Publications for ZNF398 Gene

  1. A novel zinc finger transcription factor with two isoforms that are differentially repressed by estrogen receptor-alpha. (PMID: 11779858) Conroy AT … Weigel RJ (The Journal of biological chemistry 2002) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4
  4. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZNF398 Gene

Sources for ZNF398 Gene