Aliases for ZNF396 Gene

Aliases for ZNF396 Gene

  • Zinc Finger Protein 396 2 3 4 5
  • Zinc Finger And SCAN Domain-Containing Protein 14 3 4
  • ZSCAN14 3 4

External Ids for ZNF396 Gene

Previous GeneCards Identifiers for ZNF396 Gene

  • GC18M032978
  • GC18M032766
  • GC18M032721
  • GC18M031198
  • GC18M031200
  • GC18M032946
  • GC18M029806

Summaries for ZNF396 Gene

GeneCards Summary for ZNF396 Gene

ZNF396 (Zinc Finger Protein 396) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity. An important paralog of this gene is ZNF24.

UniProtKB/Swiss-Prot Summary for ZNF396 Gene

  • Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors.

Additional gene information for ZNF396 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF396 Gene

Genomics for ZNF396 Gene

GeneHancer (GH) Regulatory Elements for ZNF396 Gene

Promoters and enhancers for ZNF396 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF396 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF396

Top Transcription factor binding sites by QIAGEN in the ZNF396 gene promoter:
  • AREB6
  • Cart-1
  • E47
  • GATA-2
  • GATA-3
  • Max1
  • Msx-1
  • MyoD
  • Nkx6-1
  • PPAR-alpha

Genomic Locations for ZNF396 Gene

Genomic Locations for ZNF396 Gene
chr18:35,366,694-35,377,337
(GRCh38/hg38)
Size:
10,644 bases
Orientation:
Minus strand
chr18:32,946,661-32,957,301
(GRCh37/hg19)
Size:
10,641 bases
Orientation:
Minus strand

Genomic View for ZNF396 Gene

Genes around ZNF396 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF396 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF396 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF396 Gene

Proteins for ZNF396 Gene

  • Protein details for ZNF396 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96N95-ZN396_HUMAN
    Recommended name:
    Zinc finger protein 396
    Protein Accession:
    Q96N95
    Secondary Accessions:
    • A1L3V0
    • Q8NF98
    • Q8TD80

    Protein attributes for ZNF396 Gene

    Size:
    335 amino acids
    Molecular mass:
    38612 Da
    Quaternary structure:
    • Isoforms 1 and 2 can both homo- and hetero-associate.

    Alternative splice isoforms for ZNF396 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF396 Gene

Post-translational modifications for ZNF396 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF396 Gene

Domains & Families for ZNF396 Gene

Gene Families for ZNF396 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF396 Gene

Blocks:
  • Transcriptional regulator SCAN
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF396 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger and SCAN domain-containing protein 14 (ZN396_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96N95

UniProtKB/Swiss-Prot:

ZN396_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF396: view

Function for ZNF396 Gene

Molecular function for ZNF396 Gene

UniProtKB/Swiss-Prot Function:
Isoform 1 and isoform 2 act as DNA-dependent transcriptional repressors.

Phenotypes From GWAS Catalog for ZNF396 Gene

Gene Ontology (GO) - Molecular Function for ZNF396 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF396: view
genes like me logo Genes that share phenotypes with ZNF396: view

Animal Model Products

CRISPR Products

miRNA for ZNF396 Gene

miRTarBase miRNAs that target ZNF396

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF396 Gene

Localization for ZNF396 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF396 Gene

[Isoform 1]: Nucleus.
[Isoform 2]: Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF396 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF396 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZNF396: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF396 Gene

Pathways & Interactions for ZNF396 Gene

PathCards logo

SuperPathways for ZNF396 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF396 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF396: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF396 Gene

Drugs & Compounds for ZNF396 Gene

No Compound Related Data Available

Transcripts for ZNF396 Gene

mRNA/cDNA for ZNF396 Gene

4 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF396 Gene

No ASD Table

Relevant External Links for ZNF396 Gene

GeneLoc Exon Structure for
ZNF396

Expression for ZNF396 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF396 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF396

SOURCE GeneReport for Unigene cluster for ZNF396 Gene:

Hs.351005

mRNA Expression by UniProt/SwissProt for ZNF396 Gene:

Q96N95-ZN396_HUMAN
Tissue specificity: Expressed strongly in liver, moderately in skeletal muscle and weakly in kidney, pancreas, spleen and prostate.

Evidence on tissue expression from TISSUES for ZNF396 Gene

  • Kidney(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF396: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF396 Gene

Orthologs for ZNF396 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF396 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF396 31 30
  • 99 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF396 31 30
  • 81.22 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF396 31
  • 59 (a)
OneToOne
Species where no ortholog for ZNF396 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF396 Gene

ENSEMBL:
Gene Tree for ZNF396 (if available)
TreeFam:
Gene Tree for ZNF396 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF396: view image

Paralogs for ZNF396 Gene

Pseudogenes.org Pseudogenes for ZNF396 Gene

genes like me logo Genes that share paralogs with ZNF396: view

Variants for ZNF396 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF396 Gene

SNP ID Clinical significance and condition Chr 18 pos Variation AA Info Type
788614 Benign: not provided 35,369,475(-) G/GT FRAMESHIFT_VARIANT
rs9963473 - p.His211Leu

Additional dbSNP identifiers (rs#s) for ZNF396 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF396 Gene

Variant ID Type Subtype PubMed ID
esv2660816 CNV deletion 23128226
esv3642200 CNV loss 21293372

Variation tolerance for ZNF396 Gene

Residual Variation Intolerance Score: 74.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.28; 53.02% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF396 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF396

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF396 Gene

Disorders for ZNF396 Gene

Additional Disease Information for ZNF396

No disorders were found for ZNF396 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF396 Gene

Publications for ZNF396 Gene

No publications were found for ZNF396 Gene.

Products for ZNF396 Gene

Sources for ZNF396 Gene