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Aliases for ZNF395 Gene

Aliases for ZNF395 Gene

  • Zinc Finger Protein 395 2 3 5
  • Huntington Disease Gene Regulatory Region-Binding Protein 2 3 4
  • HD Gene Regulatory Region-Binding Protein 2 3 4
  • Papillomavirus Regulatory Factor 1 3 4
  • Papillomavirus-Binding Factor 3 4
  • HD-Regulating Factor 2 3 4
  • HDBP-2 3 4
  • HDRF-2 3 4
  • HDBP2 3 4
  • PRF-1 3 4
  • PBF 3 4
  • Huntingtons Disease Gene Regulatory Region-Binding Protein 2 3
  • Papillomavirus Regulatory Factor PRF-1 3
  • Si-1-8-14 3
  • PRF1 3

External Ids for ZNF395 Gene

Previous GeneCards Identifiers for ZNF395 Gene

  • GC08M028228
  • GC08M028260
  • GC08M028261
  • GC08M026748
  • GC08M028203

Summaries for ZNF395 Gene

GeneCards Summary for ZNF395 Gene

ZNF395 (Zinc Finger Protein 395) is a Protein Coding gene. Diseases associated with ZNF395 include Huntington Disease. Gene Ontology (GO) annotations related to this gene include RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ZNF704.

UniProtKB/Swiss-Prot for ZNF395 Gene

  • Plays a role in papillomavirus genes transcription.

Additional gene information for ZNF395 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF395 Gene

Genomics for ZNF395 Gene

GeneHancer (GH) Regulatory Elements for ZNF395 Gene

Promoters and enhancers for ZNF395 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I028378 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.4 +19.0 18967 10.1 ATF1 FOXA2 ARID4B SIN3A ZNF2 YY1 ZNF121 GLIS2 FOS ATF7 ZNF395 FBXO16 FZD3 INTS9 PIR39512
GH08I028398 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 569.3 +1.7 1691 5 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF395 ENSG00000259366 INTS9 FZD3 ENSG00000253567 HMBOX1 PIR39512 FBXO16
GH08I028403 Enhancer 0.4 dbSUPER 550.8 -1.5 -1466 0.6 PKNOX1 RFX1 ZNF395 GC08P028417 FBXO16
GH08I028363 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.6 +32.8 32801 13.8 HDGF FOXA2 PKNOX1 SMAD1 ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 FZD3 FBXO16 ZNF395 ENSG00000253690 PNOC PIR39512
GH08I029124 Enhancer 1.2 Ensembl ENCODE 11.6 -723.3 -723349 2.5 PKNOX1 FEZF1 ZNF2 YY1 ZNF213 FOS SP3 ZNF592 MEF2D ZNF610 ENSG00000259366 ZNF395 EXTL3-AS1 INTS9 FZD3 ENSG00000254129 GC08P029142 KIF13B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF395 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF395 gene promoter:

Genomic Locations for ZNF395 Gene

Genomic Locations for ZNF395 Gene
chr8:28,345,585-28,402,701
(GRCh38/hg38)
Size:
57,117 bases
Orientation:
Minus strand
chr8:28,203,102-28,260,218
(GRCh37/hg19)

Genomic View for ZNF395 Gene

Genes around ZNF395 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF395 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF395 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF395 Gene

Proteins for ZNF395 Gene

  • Protein details for ZNF395 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8N7-ZN395_HUMAN
    Recommended name:
    Zinc finger protein 395
    Protein Accession:
    Q9H8N7
    Secondary Accessions:
    • B3KUY7
    • D3DST4
    • Q6F6H2
    • Q9BY72
    • Q9NPB2
    • Q9NS57
    • Q9NS58
    • Q9NS59

    Protein attributes for ZNF395 Gene

    Size:
    513 amino acids
    Molecular mass:
    54939 Da
    Quaternary structure:
    • Interacts with repression-mediating E2 binding site P2 of human papillomavirus type 8 (HPV8).

neXtProt entry for ZNF395 Gene

Post-translational modifications for ZNF395 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF395 Gene

Domains & Families for ZNF395 Gene

Gene Families for ZNF395 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF395 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF395 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF395: view

No data available for UniProtKB/Swiss-Prot for ZNF395 Gene

Function for ZNF395 Gene

Molecular function for ZNF395 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in papillomavirus genes transcription.

Phenotypes From GWAS Catalog for ZNF395 Gene

Gene Ontology (GO) - Molecular Function for ZNF395 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IMP 14625278
GO:0001158 enhancer sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IDA,IEA 14625278
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF395: view

Phenotypes for ZNF395 Gene

genes like me logo Genes that share phenotypes with ZNF395: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF395 Gene

Localization for ZNF395 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF395 Gene

Cytoplasm. Nucleus. Note=May shuttle between nucleus and cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF395 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF395 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 14625278
GO:0005737 cytoplasm IDA,IEA 14625278
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF395: view

Pathways & Interactions for ZNF395 Gene

SuperPathways for ZNF395 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF395 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IC,IEA 14625278
GO:0006357 regulation of transcription by RNA polymerase II IBA --
genes like me logo Genes that share ontologies with ZNF395: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF395 Gene

Drugs & Compounds for ZNF395 Gene

No Compound Related Data Available

Transcripts for ZNF395 Gene

Unigene Clusters for ZNF395 Gene

Zinc finger protein 395:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF395 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a ·
SP1: -
SP2: - -
SP3: - - - - - - -
SP4:
SP5: - - - - -
SP6: - - - - -
SP7: - - - -
SP8:
SP9: -
SP10: - - - - - - - - - -
SP11: - - - - - -
SP12: - - - - -
SP13: - - -
SP14:
SP15:
SP16: - -
SP17: - - - - - - - - - -
SP18: - - -
SP19: - -
SP20:
SP21:

ExUns: 18b ^ 19a · 19b · 19c · 19d · 19e ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27 ^ 28a · 28b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:

Relevant External Links for ZNF395 Gene

GeneLoc Exon Structure for
ZNF395
ECgene alternative splicing isoforms for
ZNF395

Expression for ZNF395 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF395 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF395 Gene:

ZNF395

SOURCE GeneReport for Unigene cluster for ZNF395 Gene:

Hs.435535

mRNA Expression by UniProt/SwissProt for ZNF395 Gene:

Q9H8N7-ZN395_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for ZNF395 Gene

  • Liver(4.2)
  • Nervous system(2.9)
  • Eye(2.2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with ZNF395: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF395 Gene

Orthologs for ZNF395 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF395 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF395 33 34
  • 99.22 (n)
dog
(Canis familiaris)
Mammalia ZNF395 33 34
  • 86.99 (n)
cow
(Bos Taurus)
Mammalia ZNF395 33 34
  • 86.38 (n)
mouse
(Mus musculus)
Mammalia Zfp395 33 16 34
  • 82.97 (n)
rat
(Rattus norvegicus)
Mammalia Zfp395 33
  • 82.44 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF395 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF395 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF395 33 34
  • 70.55 (n)
lizard
(Anolis carolinensis)
Reptilia ZNF395 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf395 33
  • 65.65 (n)
Str.8192 33
zebrafish
(Danio rerio)
Actinopterygii znf395a 33 34
  • 56.9 (n)
znf395b 34
  • 41 (a)
OneToMany
wufa14e01 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13270 33
fruit fly
(Drosophila melanogaster)
Insecta Glut4EF 34
  • 17 (a)
OneToMany
Species where no ortholog for ZNF395 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF395 Gene

ENSEMBL:
Gene Tree for ZNF395 (if available)
TreeFam:
Gene Tree for ZNF395 (if available)

Paralogs for ZNF395 Gene

Paralogs for ZNF395 Gene

(1) SIMAP similar genes for ZNF395 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ZNF395: view

Variants for ZNF395 Gene

Sequence variations from dbSNP and Humsavar for ZNF395 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000097506 -- 28,381,360(-) T/C intron_variant
rs1000172920 -- 28,359,133(-) A/C intron_variant
rs1000261658 -- 28,347,775(-) A/G 3_prime_UTR_variant
rs1000273344 -- 28,365,356(-) C/T intron_variant
rs1000283474 -- 28,352,916(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF395 Gene

Variant ID Type Subtype PubMed ID
dgv456n21 CNV gain 19592680
esv2668490 CNV deletion 23128226
esv3616737 CNV loss 21293372
nsv1076076 CNV deletion 25765185
nsv1122189 CNV deletion 24896259
nsv6135 CNV deletion 18451855
nsv824583 CNV gain 20364138
nsv824584 CNV gain 20364138

Variation tolerance for ZNF395 Gene

Residual Variation Intolerance Score: 10.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.71; 32.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF395 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF395

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF395 Gene

Disorders for ZNF395 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF395 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
huntington disease
  • hd
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF395

genes like me logo Genes that share disorders with ZNF395: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF395 Gene

Publications for ZNF395 Gene

  1. Novel nuclear shuttle proteins, HDBP1 and HDBP2, bind to neuronal cell-specific cis-regulatory element in the promoter for the human Huntington's disease gene. (PMID: 14625278) Tanaka K … Ikeda JE (The Journal of biological chemistry 2004) 2 3 4 22 58
  2. A new cellular factor recognizes E2 binding sites of papillomaviruses which mediate transcriptional repression by E2. (PMID: 11853404) Boeckle S … Steger G (Virology 2002) 3 4 22 58
  3. Scythe/BAT3 regulates apoptotic cell death induced by papillomavirus binding factor in human osteosarcoma. (PMID: 19018758) Tsukahara T … Sato N (Cancer science 2009) 3 22 58
  4. Papillomavirus binding factor (PBF)-mediated inhibition of cell growth is regulated by 14-3-3beta. (PMID: 17531190) Sichtig N … Steger G (Archives of biochemistry and biophysics 2007) 3 22 58
  5. Papillomavirus binding factor binds to SAP30 and represses transcription via recruitment of the HDAC1 co-repressor complex. (PMID: 17897615) Sichtig N … Steger G (Archives of biochemistry and biophysics 2007) 3 22 58

Products for ZNF395 Gene

Sources for ZNF395 Gene

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