The protein encoded by this gene is a zinc finger protein that inhibits the transcription of mitogen-activated protein kinase signaling pathways. The encoded protein may be involved in cardiac function. [provided by RefSeq, Sep 2016] See more...

Aliases for ZNF394 Gene

Aliases for ZNF394 Gene

  • Zinc Finger Protein 394 2 3 4 5
  • Zinc Finger Protein With KRAB And SCAN Domains 14 3 4
  • ZKSCAN14 3 4
  • Zinc Finger Protein 99 3
  • ZSCAN46 3

External Ids for ZNF394 Gene

Previous GeneCards Identifiers for ZNF394 Gene

  • GC00U991239
  • GC07M098702
  • GC07M098735
  • GC07M098928
  • GC07M099088
  • GC07M093727

Summaries for ZNF394 Gene

Entrez Gene Summary for ZNF394 Gene

  • The protein encoded by this gene is a zinc finger protein that inhibits the transcription of mitogen-activated protein kinase signaling pathways. The encoded protein may be involved in cardiac function. [provided by RefSeq, Sep 2016]

GeneCards Summary for ZNF394 Gene

ZNF394 (Zinc Finger Protein 394) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF263.

UniProtKB/Swiss-Prot Summary for ZNF394 Gene

Additional gene information for ZNF394 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF394 Gene

Genomics for ZNF394 Gene

GeneHancer (GH) Regulatory Elements for ZNF394 Gene

Promoters and enhancers for ZNF394 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF394 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF394

Top Transcription factor binding sites by QIAGEN in the ZNF394 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • Nkx3-1
  • Nkx3-1 v2
  • Olf-1

Genomic Locations for ZNF394 Gene

Genomic Locations for ZNF394 Gene
chr7:99,473,877-99,504,857
(GRCh38/hg38)
Size:
30,981 bases
Orientation:
Minus strand
chr7:99,084,142-99,097,947
(GRCh37/hg19)
Size:
13,806 bases
Orientation:
Minus strand

Genomic View for ZNF394 Gene

Genes around ZNF394 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF394 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF394 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF394 Gene

Proteins for ZNF394 Gene

  • Protein details for ZNF394 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53GI3-ZN394_HUMAN
    Recommended name:
    Zinc finger protein 394
    Protein Accession:
    Q53GI3
    Secondary Accessions:
    • A4D281
    • Q05DA6
    • Q6P5X9
    • Q8TB27
    • Q9HA37
    • Q9UD51

    Protein attributes for ZNF394 Gene

    Size:
    561 amino acids
    Molecular mass:
    64256 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF394 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF394 Gene

Post-translational modifications for ZNF394 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF394 Gene

No data available for DME Specific Peptides for ZNF394 Gene

Domains & Families for ZNF394 Gene

Gene Families for ZNF394 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF394 Gene

Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
  • Transcriptional regulator SCAN
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF394 Gene

GenScript: Design optimal peptide antigens:
  • ZNF394 protein (Q05DA6_HUMAN)
  • Zinc finger protein with KRAB and SCAN domains 14 (ZN394_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q53GI3

UniProtKB/Swiss-Prot:

ZN394_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF394: view

Function for ZNF394 Gene

Molecular function for ZNF394 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF394 Gene

Gene Ontology (GO) - Molecular Function for ZNF394 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF394: view
genes like me logo Genes that share phenotypes with ZNF394: view

Animal Models for ZNF394 Gene

MGI Knock Outs for ZNF394:

Animal Model Products

CRISPR Products

miRNA for ZNF394 Gene

miRTarBase miRNAs that target ZNF394

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF394

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF394 Gene

Localization for ZNF394 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF394 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF394 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF394 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF394: view

Pathways & Interactions for ZNF394 Gene

PathCards logo

SuperPathways for ZNF394 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF394: view

Pathways by source for ZNF394 Gene

2 Reactome pathways for ZNF394 Gene

Gene Ontology (GO) - Biological Process for ZNF394 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF394: view

No data available for SIGNOR curated interactions for ZNF394 Gene

Drugs & Compounds for ZNF394 Gene

No Compound Related Data Available

Transcripts for ZNF394 Gene

mRNA/cDNA for ZNF394 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF394

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF394 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b
SP1: -
SP2: - -
SP3:

Relevant External Links for ZNF394 Gene

GeneLoc Exon Structure for
ZNF394

Expression for ZNF394 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF394 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF394 Gene

This gene is overexpressed in Whole Blood (x6.3).

Protein differential expression in normal tissues from HIPED for ZNF394 Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF394 Gene



Protein tissue co-expression partners for ZNF394 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF394

SOURCE GeneReport for Unigene cluster for ZNF394 Gene:

Hs.386324

Evidence on tissue expression from TISSUES for ZNF394 Gene

  • Lung(4.3)
  • Intestine(4.2)
  • Kidney(4.2)
  • Skin(4.2)
  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with ZNF394: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF394 Gene

Orthologs for ZNF394 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF394 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF394 31 30
  • 99.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF394 31 30
  • 78.16 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF394 31 30
  • 75.8 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp394 30
  • 74.65 (n)
mouse
(Mus musculus)
Mammalia Zkscan14 17 31 30
  • 74.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 36 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 33 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ZFP92 31
  • 39 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 26 (a)
ManyToMany
Species where no ortholog for ZNF394 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF394 Gene

ENSEMBL:
Gene Tree for ZNF394 (if available)
TreeFam:
Gene Tree for ZNF394 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF394: view image

Paralogs for ZNF394 Gene

(387) SIMAP similar genes for ZNF394 Gene using alignment to 2 proteins:

  • ZN394_HUMAN
  • Q05DA6_HUMAN
genes like me logo Genes that share paralogs with ZNF394: view

Variants for ZNF394 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF394 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
rs3735454 - p.Thr325Met

Additional dbSNP identifiers (rs#s) for ZNF394 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF394 Gene

Variant ID Type Subtype PubMed ID
esv3576408 CNV gain 25503493
nsv1137272 CNV deletion 24896259
nsv831069 CNV loss 17160897

Variation tolerance for ZNF394 Gene

Residual Variation Intolerance Score: 40.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF394 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF394

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF394 Gene

Disorders for ZNF394 Gene

Additional Disease Information for ZNF394

No disorders were found for ZNF394 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF394 Gene

Publications for ZNF394 Gene

No publications were found for ZNF394 Gene.

Products for ZNF394 Gene

Sources for ZNF394 Gene