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Aliases for ZNF391 Gene

Aliases for ZNF391 Gene

  • Zinc Finger Protein 391 2 3 5
  • DJ153G14.3 3

External Ids for ZNF391 Gene

Previous GeneCards Identifiers for ZNF391 Gene

  • GC00U914161
  • GC06U900622
  • GC06P027477
  • GC06P027166

Summaries for ZNF391 Gene

GeneCards Summary for ZNF391 Gene

ZNF391 (Zinc Finger Protein 391) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is LOC344065.

UniProtKB/Swiss-Prot for ZNF391 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF391 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF391 Gene

Genomics for ZNF391 Gene

GeneHancer (GH) Regulatory Elements for ZNF391 Gene

Promoters and enhancers for ZNF391 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I027388 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 616.8 +14.3 14286 1.8 CLOCK MLX ZFP64 DMAP1 IRF4 ZNF213 E2F8 ZNF416 ZNF143 ZNF263 ZNF391 GC06P027389 GC06M027388 ZKSCAN3 ZKSCAN8 ZNF204P PGBD1 ABT1 ZSCAN9 ZKSCAN4
GH06I027374 Promoter/Enhancer 1.4 Ensembl ENCODE 596.3 +0.6 613 2 PKNOX1 ATF1 ARID4B SIN3A ETS1 ZNF766 ZNF213 ZNF143 ATF7 RUNX3 ZNF391 PIR52991 ZNF204P ZNF184 LOC102724851 BTN2A2 ZNF603P ABT1
GH06I027126 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 41.8 -236.6 -236593 23 CLOCK FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC HIST1H2AH GC06P027140 HIST1H2AG HIST1H4I HIST1H2BJ HIST1H2BK ZKSCAN8 ABT1 HMGN4 BTN2A1
GH06I027477 Enhancer 1.5 Ensembl ENCODE dbSUPER 67 +104.4 104386 2.8 ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZC3H11A PPARGC1A MEF2D TRD-GTC2-6 TRS-AGA2-2 ZNF391 PGBD1 ZKSCAN8 ABT1 ZSCAN12 ZKSCAN3 ZKSCAN4 ZSCAN9
GH06I027494 Enhancer 1.3 Ensembl ENCODE 72.5 +121.0 121034 1.7 FEZF1 ZNF213 E2F8 ZNF143 SP3 ZFP41 MEF2D SSRP1 ZNF610 RCOR2 TRS-AGA2-3 ZSCAN12 ZSCAN23 ZKSCAN8 PGBD1 ZNF322 ZKSCAN3 ZSCAN9 ZNF391 ENSG00000261839
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF391 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF391 Gene

Genomic Locations for ZNF391 Gene
29,294 bases
Plus strand

Genomic View for ZNF391 Gene

Genes around ZNF391 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF391 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF391 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF391 Gene

Proteins for ZNF391 Gene

  • Protein details for ZNF391 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 391
    Protein Accession:
    Secondary Accessions:
    • B4DH77

    Protein attributes for ZNF391 Gene

    358 amino acids
    Molecular mass:
    40659 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB51755.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF391 Gene

Post-translational modifications for ZNF391 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF391 Gene

No data available for DME Specific Peptides for ZNF391 Gene

Domains & Families for ZNF391 Gene

Gene Families for ZNF391 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF391 Gene

Suggested Antigen Peptide Sequences for ZNF391 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF391: view

Function for ZNF391 Gene

Molecular function for ZNF391 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF391 Gene

Gene Ontology (GO) - Molecular Function for ZNF391 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF391: view

Phenotypes for ZNF391 Gene

GenomeRNAi human phenotypes for ZNF391:
genes like me logo Genes that share phenotypes with ZNF391: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF391 Gene

Localization for ZNF391 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF391 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF391 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ZNF391 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF391: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF391 Gene

Pathways & Interactions for ZNF391 Gene

SuperPathways for ZNF391 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF391 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
genes like me logo Genes that share ontologies with ZNF391: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF391 Gene

Drugs & Compounds for ZNF391 Gene

No Compound Related Data Available

Transcripts for ZNF391 Gene

mRNA/cDNA for ZNF391 Gene

(8) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF391 Gene

Zinc finger protein 391:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF391 Gene

No ASD Table

Relevant External Links for ZNF391 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF391 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF391 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF391 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF391 Gene:


SOURCE GeneReport for Unigene cluster for ZNF391 Gene:


Evidence on tissue expression from TISSUES for ZNF391 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF391: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF391 Gene

Orthologs for ZNF391 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF391 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF391 33 34
  • 99.26 (n)
(Bos Taurus)
Mammalia ZNF391 33 34
  • 88.64 (n)
(Canis familiaris)
Mammalia ZNF391 33 34
  • 85.64 (n)
(Monodelphis domestica)
Mammalia ZNF391 34
  • 32 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491165 33
  • 62.23 (n)
Species where no ortholog for ZNF391 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF391 Gene

Gene Tree for ZNF391 (if available)
Gene Tree for ZNF391 (if available)

Paralogs for ZNF391 Gene

(517) SIMAP similar genes for ZNF391 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF391: view

Variants for ZNF391 Gene

Sequence variations from dbSNP and Humsavar for ZNF391 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000018252 -- 27,372,807(+) G/A upstream_transcript_variant
rs1000164453 -- 27,401,337(+) C/T coding_sequence_variant, missense_variant
rs1000220226 -- 27,388,971(+) A/T 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000263524 -- 27,393,621(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000308850 -- 27,402,091(+) G/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF391 Gene

Variant ID Type Subtype PubMed ID
nsv517557 CNV loss 19592680
nsv5234 CNV insertion 18451855
nsv5235 CNV deletion 18451855

Variation tolerance for ZNF391 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF391 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF391 Gene

Disorders for ZNF391 Gene

Additional Disease Information for ZNF391

No disorders were found for ZNF391 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF391 Gene

Publications for ZNF391 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. Keep your fingers off my DNA: protein-protein interactions mediated by C2H2 zinc finger domains. (PMID: 18253864) Brayer KJ … Segal DJ (Cell biochemistry and biophysics 2008) 3 58
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 58

Products for ZNF391 Gene

Sources for ZNF391 Gene

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