Aliases for ZNF391 Gene

Aliases for ZNF391 Gene

  • Zinc Finger Protein 391 2 3 4 5
  • DJ153G14.3 2 3
  • ZNF391 5

External Ids for ZNF391 Gene

Previous GeneCards Identifiers for ZNF391 Gene

  • GC00U914161
  • GC06U900622
  • GC06P027477
  • GC06P027342
  • GC06P027166

Summaries for ZNF391 Gene

GeneCards Summary for ZNF391 Gene

ZNF391 (Zinc Finger Protein 391) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF33B.

UniProtKB/Swiss-Prot Summary for ZNF391 Gene

Additional gene information for ZNF391 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF391 Gene

Genomics for ZNF391 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF391 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF391 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF391

Genomic Locations for ZNF391 Gene

Genomic Locations for ZNF391 Gene
chr6:27,374,615-27,403,908
(GRCh38/hg38)
Size:
29,294 bases
Orientation:
Plus strand
chr6:27,342,394-27,371,683
(GRCh37/hg19)
Size:
29,290 bases
Orientation:
Plus strand

Genomic View for ZNF391 Gene

Genes around ZNF391 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF391 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF391 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF391 Gene

Proteins for ZNF391 Gene

  • Protein details for ZNF391 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJN7-ZN391_HUMAN
    Recommended name:
    Zinc finger protein 391
    Protein Accession:
    Q9UJN7
    Secondary Accessions:
    • B4DH77

    Protein attributes for ZNF391 Gene

    Size:
    358 amino acids
    Molecular mass:
    40659 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF391 Gene

Post-translational modifications for ZNF391 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF391 Gene

No data available for DME Specific Peptides for ZNF391 Gene

Domains & Families for ZNF391 Gene

Gene Families for ZNF391 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF391 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF391 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 391 (ZN391_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UJN7

UniProtKB/Swiss-Prot:

ZN391_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF391: view

Function for ZNF391 Gene

Molecular function for ZNF391 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF391 Gene

Gene Ontology (GO) - Molecular Function for ZNF391 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0043565 sequence-specific DNA binding IBA 21873635
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF391: view

Phenotypes for ZNF391 Gene

genes like me logo Genes that share phenotypes with ZNF391: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF391

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF391 Gene

Localization for ZNF391 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF391 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF391 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF391 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF391: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF391 Gene

Pathways & Interactions for ZNF391 Gene

PathCards logo

SuperPathways for ZNF391 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF391 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF391: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF391 Gene

Drugs & Compounds for ZNF391 Gene

No Compound Related Data Available

Transcripts for ZNF391 Gene

mRNA/cDNA for ZNF391 Gene

5 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF391

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF391 Gene

No ASD Table

Relevant External Links for ZNF391 Gene

GeneLoc Exon Structure for
ZNF391

Expression for ZNF391 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF391 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF391 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF391

SOURCE GeneReport for Unigene cluster for ZNF391 Gene:

Hs.651176

Evidence on tissue expression from TISSUES for ZNF391 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF391: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF391 Gene

Orthologs for ZNF391 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF391 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF391 30 31
  • 99.26 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF391 30 31
  • 88.64 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF391 30 31
  • 85.64 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF391 31
  • 32 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100491165 30
  • 62.23 (n)
Species where no ortholog for ZNF391 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF391 Gene

ENSEMBL:
Gene Tree for ZNF391 (if available)
TreeFam:
Gene Tree for ZNF391 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF391: view image

Paralogs for ZNF391 Gene

Paralogs for ZNF391 Gene

(517) SIMAP similar genes for ZNF391 Gene using alignment to 2 proteins:

  • ZN391_HUMAN
  • C9JUF8_HUMAN
genes like me logo Genes that share paralogs with ZNF391: view

Variants for ZNF391 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF391 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs10807020 - p.Lys51Arg
rs10807021 - p.Gly59Cys

Additional dbSNP identifiers (rs#s) for ZNF391 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF391 Gene

Variant ID Type Subtype PubMed ID
nsv517557 CNV loss 19592680
nsv5234 CNV insertion 18451855
nsv5235 CNV deletion 18451855

Variation tolerance for ZNF391 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF391 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF391

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF391 Gene

Disorders for ZNF391 Gene

Additional Disease Information for ZNF391

No disorders were found for ZNF391 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF391 Gene

Publications for ZNF391 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. (PMID: 30631154) Hu Q … Yang L (Cell research 2019) 3
  3. SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes. (PMID: 27545878) Kupka S … Walczak H (Cell reports 2016) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for ZNF391 Gene

Sources for ZNF391 Gene