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Aliases for ZNF385D Gene

Aliases for ZNF385D Gene

  • Zinc Finger Protein 385D 2 3 5
  • Zinc Finger Protein 659 2 3 4
  • ZNF659 3 4

External Ids for ZNF385D Gene

Previous HGNC Symbols for ZNF385D Gene

  • ZNF659

Previous GeneCards Identifiers for ZNF385D Gene

  • GC03M021439
  • GC03M021412

Summaries for ZNF385D Gene

GeneCards Summary for ZNF385D Gene

ZNF385D (Zinc Finger Protein 385D) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF385B.

Additional gene information for ZNF385D Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF385D Gene

Genomics for ZNF385D Gene

GeneHancer (GH) Regulatory Elements for ZNF385D Gene

Promoters and enhancers for ZNF385D Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I021749 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 550 +622.4 622425 2.5 POLR2A CTBP2 ZNF385D PIR55547 ZNF385D-AS2
GH03I022450 Enhancer 0.5 ENCODE 11.1 -77.8 -77845 1.5 JUND POLR2A RCOR1 CHD2 ZNF385D GC03P022382 GC03P022586
GH03I021839 Enhancer 0.5 ENCODE 8.7 +533.7 533716 1 CTCF JUND RXRA RAD21 NR2F2 ZNF385D ZNF385D-AS2 PIR55547
GH03I021856 Enhancer 0.2 FANTOM5 6.6 +516.4 516444 0.2 ZNF385D ZNF385D-AS2 PIR55547
GH03I021393 Enhancer 0.2 ENCODE 5.2 +979.4 979390 1.5 ZNF385D VENTXP7 PIR40083
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF385D on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF385D Gene

Genomic Locations for ZNF385D Gene
961,100 bases
Minus strand

Genomic View for ZNF385D Gene

Genes around ZNF385D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF385D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF385D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF385D Gene

Proteins for ZNF385D Gene

  • Protein details for ZNF385D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 385D
    Protein Accession:

    Protein attributes for ZNF385D Gene

    395 amino acids
    Molecular mass:
    42296 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF385D Gene

Post-translational modifications for ZNF385D Gene

No Post-translational modifications

No data available for DME Specific Peptides for ZNF385D Gene

Domains & Families for ZNF385D Gene

Gene Families for ZNF385D Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ZNF385D Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF385D: view

No data available for UniProtKB/Swiss-Prot for ZNF385D Gene

Function for ZNF385D Gene

Phenotypes From GWAS Catalog for ZNF385D Gene

Gene Ontology (GO) - Molecular Function for ZNF385D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IBA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF385D: view

Phenotypes for ZNF385D Gene

genes like me logo Genes that share phenotypes with ZNF385D: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF385D Gene

Localization for ZNF385D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF385D Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF385D gene
Compartment Confidence
nucleus 3
plasma membrane 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ZNF385D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF385D: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF385D Gene

Pathways & Interactions for ZNF385D Gene

SuperPathways for ZNF385D Gene

No Data Available

Interacting Proteins for ZNF385D Gene

Selected Interacting proteins: Q9H6B1-Z385D_HUMAN for ZNF385D Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ZNF385D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IBA --
genes like me logo Genes that share ontologies with ZNF385D: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF385D Gene

Drugs & Compounds for ZNF385D Gene

No Compound Related Data Available

Transcripts for ZNF385D Gene

Unigene Clusters for ZNF385D Gene

Zinc finger protein 385D:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF385D Gene

No ASD Table

Relevant External Links for ZNF385D Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF385D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF385D Gene

mRNA differential expression in normal tissues according to GTEx for ZNF385D Gene

This gene is overexpressed in Artery - Aorta (x6.6).

Protein differential expression in normal tissues from HIPED for ZNF385D Gene

This gene is overexpressed in Vitreous humor (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF385D Gene

Protein tissue co-expression partners for ZNF385D Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF385D Gene:


SOURCE GeneReport for Unigene cluster for ZNF385D Gene:


Evidence on tissue expression from TISSUES for ZNF385D Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with ZNF385D: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF385D Gene

Orthologs for ZNF385D Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF385D Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 99 (a)
-- 34
  • 85 (a)
(Pan troglodytes)
Mammalia ZNF385D 33 34
  • 95.58 (n)
(Canis familiaris)
Mammalia ZNF385D 33 34
  • 94.49 (n)
(Monodelphis domestica)
Mammalia ZNF385D 34
  • 90 (a)
(Rattus norvegicus)
Mammalia Zfp385d 33
  • 87.79 (n)
(Bos Taurus)
Mammalia ZNF385D 33
  • 84.99 (n)
(Gallus gallus)
Aves ZNF385D 33 34
  • 88.86 (n)
(Anolis carolinensis)
Reptilia ZNF385D 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf385d 33
  • 76.36 (n)
(Danio rerio)
Actinopterygii ZNF385D 34
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 17 (a)
Species where no ortholog for ZNF385D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF385D Gene

Gene Tree for ZNF385D (if available)
Gene Tree for ZNF385D (if available)

Paralogs for ZNF385D Gene

Paralogs for ZNF385D Gene

(4) SIMAP similar genes for ZNF385D Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF385D: view

Variants for ZNF385D Gene

Sequence variations from dbSNP and Humsavar for ZNF385D Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
VAR_036058 A colorectal cancer sample p.Ala386Thr
VAR_036059 A colorectal cancer sample p.His387Gln
rs1000002109 -- 22,075,224(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000004343 -- 21,674,882(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000006494 -- 22,294,527(-) G/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF385D Gene

Variant ID Type Subtype PubMed ID
nsv1117330 CNV tandem duplication 24896259
nsv1114363 CNV deletion 24896259
nsv1011226 CNV loss 25217958
nsv1010460 CNV loss 25217958
nsv1007665 CNV gain 25217958
nsv1006471 CNV gain 25217958
nsv1003451 CNV loss 25217958
esv5738 CNV loss 19470904
esv3595518 CNV loss 21293372
esv3595517 CNV loss 21293372
esv3595516 CNV loss 21293372
esv3595515 CNV loss 21293372
esv3595514 CNV loss 21293372
esv3595513 CNV loss 21293372
esv3595512 CNV loss 21293372
esv3568639 CNV loss 25503493
esv3561580 CNV deletion 23714750
esv3385081 CNV insertion 20981092
esv3374441 CNV insertion 20981092
esv3306835 CNV mobile element insertion 20981092
esv28084 CNV loss 19812545
esv2751992 CNV gain 17911159
esv2725026 CNV deletion 23290073
esv2725025 CNV deletion 23290073
esv2725024 CNV deletion 23290073
esv2668952 CNV deletion 23128226
esv2665339 CNV deletion 23128226
esv2657428 CNV deletion 23128226
esv21508 CNV gain 19812545
dgv8263n54 CNV loss 21841781
dgv8262n54 CNV loss 21841781
dgv8261n54 CNV loss 21841781
dgv8260n54 CNV loss 21841781
dgv8259n54 CNV loss 21841781
dgv8258n54 CNV loss 21841781
dgv799n67 CNV loss 20364138
dgv4691n100 CNV gain 25217958
nsv997790 CNV loss 25217958
nsv997373 CNV loss 25217958
nsv979810 CNV duplication 23825009
nsv963302 CNV duplication 23825009
nsv834631 CNV gain 17160897
nsv834630 CNV loss 17160897
nsv822029 CNV gain 20364138
nsv589923 CNV loss 21841781
nsv589897 CNV loss 21841781
nsv589896 CNV loss 21841781
nsv589895 CNV loss 21841781
nsv527771 CNV loss 19592680
nsv522577 CNV loss 19592680
nsv514140 CNV loss 21397061
nsv238000 CNV deletion 16902084

Variation tolerance for ZNF385D Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 61.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF385D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF385D Gene

Disorders for ZNF385D Gene

Additional Disease Information for ZNF385D

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF385D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF385D Gene

Publications for ZNF385D Gene

  1. Host determinants of HIV-1 control in African Americans. (PMID: 20205591) Pelak K … National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI) (The Journal of infectious diseases 2010) 3 44 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. (PMID: 20522523) Kasperaviciūte D … Sisodiya SM (Brain : a journal of neurology 2010) 3 44 58
  4. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PMID: 18821565) Lasky-Su J … Faraone SV (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 44 58
  5. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. (PMID: 18711365) Ferreira MA … Wellcome Trust Case Control Consortium (Nature genetics 2008) 3 44 58

Products for ZNF385D Gene

Sources for ZNF385D Gene

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