Aliases for ZNF385D Gene

Aliases for ZNF385D Gene

  • Zinc Finger Protein 385D 2 3 4 5
  • Zinc Finger Protein 659 2 3 4
  • ZNF659 3 4

External Ids for ZNF385D Gene

Previous HGNC Symbols for ZNF385D Gene

  • ZNF659

Previous GeneCards Identifiers for ZNF385D Gene

  • GC03M021439
  • GC03M021459

Summaries for ZNF385D Gene

GeneCards Summary for ZNF385D Gene

ZNF385D (Zinc Finger Protein 385D) is a Protein Coding gene. Diseases associated with ZNF385D include Porencephaly and Reading Disorder. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF385B.

Additional gene information for ZNF385D Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF385D Gene

Genomics for ZNF385D Gene

GeneHancer (GH) Regulatory Elements for ZNF385D Gene

Promoters and enhancers for ZNF385D Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J021749 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE CraniofacialAtlas 500 +623.0 623042 3.8 REST SAP30 MXI1 POLR2A PHF8 FOXP2 TAF1 SMARCA4 JUND TBP ZNF385D piR-35674-347 piR-57133-412 lnc-ZNF385D-3
GH03J022372 Promoter 1 EPDnew Ensembl 505.7 +1.0 1020 1.4 HDAC2 EZH2 SMC3 CHD1 SUZ12 TBP POLR2A RAD21 ZNF385D lnc-ZNF385D-3 RF00017-3939
GH03J022450 Enhancer 0.7 Ensembl ENCODE 11.1 -77.8 -77845 1.5 GATA3 JUND RCOR1 POLR2A GATA1 CHD2 GATA2 RAD21 ZNF385D lnc-ZNF385D-2 piR-39858-449
GH03J021839 Enhancer 0.7 Ensembl ENCODE 8.7 +533.7 533709 1 CTCF TEAD4 SMC3 NR2F2 RXRA JUND FOXP2 EGR1 RAD21 NR2F6 ZNF385D piR-40110-498 lnc-UBE2E2-7 lnc-ZNF385D-3
GH03J022322 Enhancer 0.3 Ensembl 11.4 +50.1 50120 0.8 ETS1 ZNF385D RF00017-3939 lnc-ZNF385D-3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF385D on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF385D

Genomic Locations for ZNF385D Gene

Genomic Locations for ZNF385D Gene
961,104 bases
Minus strand
954,898 bases
Minus strand

Genomic View for ZNF385D Gene

Genes around ZNF385D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF385D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF385D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF385D Gene

Proteins for ZNF385D Gene

  • Protein details for ZNF385D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 385D
    Protein Accession:

    Protein attributes for ZNF385D Gene

    395 amino acids
    Molecular mass:
    42296 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF385D Gene

Post-translational modifications for ZNF385D Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF385D Gene

Domains & Families for ZNF385D Gene

Gene Families for ZNF385D Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF385D Gene

  • Zn-finger, U1-like

Suggested Antigen Peptide Sequences for ZNF385D Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 659 (Z385D_HUMAN)
genes like me logo Genes that share domains with ZNF385D: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF385D Gene

Function for ZNF385D Gene

Phenotypes From GWAS Catalog for ZNF385D Gene

Gene Ontology (GO) - Molecular Function for ZNF385D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF385D: view
genes like me logo Genes that share phenotypes with ZNF385D: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF385D Gene

Localization for ZNF385D Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF385D Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF385D gene
Compartment Confidence
nucleus 3
cytoskeleton 1
plasma membrane 0
golgi apparatus 0

Gene Ontology (GO) - Cellular Components for ZNF385D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF385D: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF385D Gene

Pathways & Interactions for ZNF385D Gene

PathCards logo

SuperPathways for ZNF385D Gene

No Data Available

Interacting Proteins for ZNF385D Gene

Selected Interacting proteins: Q9H6B1-Z385D_HUMAN for ZNF385D Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ZNF385D Gene


No data available for Pathways by source and SIGNOR curated interactions for ZNF385D Gene

Drugs & Compounds for ZNF385D Gene

(1) Drugs for ZNF385D Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
duloxetine Approved Pharma Antagonist 0
genes like me logo Genes that share compounds with ZNF385D: view

Transcripts for ZNF385D Gene

mRNA/cDNA for ZNF385D Gene

3 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF385D Gene

No ASD Table

Relevant External Links for ZNF385D Gene

GeneLoc Exon Structure for

Expression for ZNF385D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF385D Gene

mRNA differential expression in normal tissues according to GTEx for ZNF385D Gene

This gene is overexpressed in Artery - Aorta (x6.6).

Protein differential expression in normal tissues from HIPED for ZNF385D Gene

This gene is overexpressed in Vitreous humor (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF385D Gene

Protein tissue co-expression partners for ZNF385D Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF385D

SOURCE GeneReport for Unigene cluster for ZNF385D Gene:


Evidence on tissue expression from TISSUES for ZNF385D Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with ZNF385D: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF385D Gene

Orthologs for ZNF385D Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF385D Gene

Organism Taxonomy Gene Similarity Type Details
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 99 (a)
-- 31
  • 85 (a)
(Pan troglodytes)
Mammalia ZNF385D 31 30
  • 95.58 (n)
(Canis familiaris)
Mammalia ZNF385D 31 30
  • 94.49 (n)
(Monodelphis domestica)
Mammalia ZNF385D 31
  • 90 (a)
(Rattus norvegicus)
Mammalia Zfp385d 30
  • 87.79 (n)
(Bos Taurus)
Mammalia ZNF385D 30
  • 84.99 (n)
(Gallus gallus)
Aves ZNF385D 31 30
  • 88.86 (n)
(Anolis carolinensis)
Reptilia ZNF385D 31
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf385d 30
  • 76.36 (n)
(Danio rerio)
Actinopterygii ZNF385D 31
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 17 (a)
Species where no ortholog for ZNF385D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF385D Gene

Gene Tree for ZNF385D (if available)
Gene Tree for ZNF385D (if available)
Evolutionary constrained regions (ECRs) for ZNF385D: view image

Paralogs for ZNF385D Gene

Paralogs for ZNF385D Gene

(4) SIMAP similar genes for ZNF385D Gene using alignment to 2 proteins:

  • Z385D_HUMAN
genes like me logo Genes that share paralogs with ZNF385D: view

Variants for ZNF385D Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF385D Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
156842 Not Provided: Small for gestational age; Normal pregnancy 22,241,798(-) ACTCTACAAGGCAATA
713567 Benign: not provided 21,564,619(-) C/T SYNONYMOUS_VARIANT
rs757067821 A colorectal cancer sample p.Ala386Thr
VAR_036059 A colorectal cancer sample p.His387Gln

Additional dbSNP identifiers (rs#s) for ZNF385D Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF385D Gene

Variant ID Type Subtype PubMed ID
dgv4691n100 CNV gain 25217958
dgv799n67 CNV loss 20364138
dgv8258n54 CNV loss 21841781
dgv8259n54 CNV loss 21841781
dgv8260n54 CNV loss 21841781
dgv8261n54 CNV loss 21841781
dgv8262n54 CNV loss 21841781
dgv8263n54 CNV loss 21841781
esv21508 CNV gain 19812545
esv2657428 CNV deletion 23128226
esv2665339 CNV deletion 23128226
esv2668952 CNV deletion 23128226
esv2725024 CNV deletion 23290073
esv2725025 CNV deletion 23290073
esv2725026 CNV deletion 23290073
esv2751992 CNV gain 17911159
esv28084 CNV loss 19812545
esv3306835 CNV mobile element insertion 20981092
esv3374441 CNV insertion 20981092
esv3385081 CNV insertion 20981092
esv3561580 CNV deletion 23714750
esv3568639 CNV loss 25503493
esv3595512 CNV loss 21293372
esv3595513 CNV loss 21293372
esv3595514 CNV loss 21293372
esv3595515 CNV loss 21293372
esv3595516 CNV loss 21293372
esv3595517 CNV loss 21293372
esv3595518 CNV loss 21293372
esv5738 CNV loss 19470904
nsv1003451 CNV loss 25217958
nsv1006471 CNV gain 25217958
nsv1007665 CNV gain 25217958
nsv1010460 CNV loss 25217958
nsv1011226 CNV loss 25217958
nsv1114363 CNV deletion 24896259
nsv1117330 CNV tandem duplication 24896259
nsv238000 CNV deletion 16902084
nsv514140 CNV loss 21397061
nsv522577 CNV loss 19592680
nsv527771 CNV loss 19592680
nsv589895 CNV loss 21841781
nsv589896 CNV loss 21841781
nsv589897 CNV loss 21841781
nsv589923 CNV loss 21841781
nsv822029 CNV gain 20364138
nsv834630 CNV loss 17160897
nsv834631 CNV gain 17160897
nsv963302 CNV duplication 23825009
nsv979810 CNV duplication 23825009
nsv997373 CNV loss 25217958
nsv997790 CNV loss 25217958

Variation tolerance for ZNF385D Gene

Residual Variation Intolerance Score: 29.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 61.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF385D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF385D Gene

Disorders for ZNF385D Gene

MalaCards: The human disease database

(6) MalaCards diseases for ZNF385D Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
reading disorder
  • dyslexia
attention deficit-hyperactivity disorder
  • adhd
specific language impairment
  • language impairment, specific
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF385D

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF385D: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF385D Gene

Publications for ZNF385D Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. (PMID: 20522523) Kasperaviciūte D … Sisodiya SM (Brain : a journal of neurology 2010) 3 41 54
  3. Host determinants of HIV-1 control in African Americans. (PMID: 20205591) Pelak K … National Institute of Allergy and Infectious Diseases Center for HIV/AIDS Vaccine Immunology (CHAVI) (The Journal of infectious diseases 2010) 3 41 54
  4. Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations. (PMID: 18821565) Lasky-Su J … Faraone SV (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 41 54
  5. Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. (PMID: 18711365) Ferreira MA … Wellcome Trust Case Control Consortium (Nature genetics 2008) 3 41 54

Products for ZNF385D Gene

Sources for ZNF385D Gene