Aliases for ZNF385C Gene

Aliases for ZNF385C Gene

  • Zinc Finger Protein 385C 2 3 4 5
  • CTD-2132N18.2 3
  • CTD-2132N18.4 3

External Ids for ZNF385C Gene

Previous GeneCards Identifiers for ZNF385C Gene

  • GC17M037432
  • GC17M040177
  • GC17M035942

Summaries for ZNF385C Gene

GeneCards Summary for ZNF385C Gene

ZNF385C (Zinc Finger Protein 385C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF385B.

Additional gene information for ZNF385C Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF385C Gene

Genomics for ZNF385C Gene

GeneHancer (GH) Regulatory Elements for ZNF385C Gene

Promoters and enhancers for ZNF385C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J042026 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 762.4 +70.7 70741 2.7 RAD21 MNT CTCF ELF3 ZNF644 KAT8 IKZF1 REST GATAD2A KMT2B ZNF385C lnc-ZNF385C-1 DHX58 CNP KLHL11 RNU7-97P piR-57800
GH17J042097 Promoter/Enhancer 0.8 Ensembl ENCODE 750.6 +0.3 278 1.2 L3MBTL2 ZBTB8A PRDM10 ZNF335 GLIS1 ZNF385C CNP KCNH4 HCRT KLHL11 DHX58 HSALNG0116487
GH17J042015 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 +80.0 79978 6.6 SIN3A SP1 ZBTB40 CTCF ZBTB6 MLX SMARCE1 RBPJ POLR2A TCF7L2 NKIRAS2 DNAJC7 HSALNG0116480 lnc-ZNF385C-4-001 ENSG00000267758 STAT5A NAGLU STAT3 VPS25 PSME3
GH17J042120 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 12 -23.3 -23347 2.9 SIX5 ZBTB6 RBPJ POLR2A HCFC1 MYC L3MBTL2 MAX MNT ZNF148 HSPB9 KAT2A piR-30173 NKIRAS2 ZNF385C DHX58 KCNH4 HCRT RETREG3 ACLY
GH17J041965 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 +131.6 131581 3.5 ZNF24 SP1 RBPJ POLR2A HCFC1 MIXL1 MYC HLF L3MBTL2 ZNF121 CNP piR-49789 NT5C3B NKIRAS2 NAGLU ENSG00000267758 VPS25 STAT3 STAT5A DNAJC7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF385C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF385C gene promoter:
  • AML1a
  • AREB6
  • ATF6
  • Nkx2-5
  • Pax-2
  • Pax-2a
  • Roaz
  • Spz1
  • SRF
  • SRF (504 AA)

Genomic Locations for ZNF385C Gene

Genomic Locations for ZNF385C Gene
chr17:42,024,876-42,098,479
(GRCh38/hg38)
Size:
73,604 bases
Orientation:
Minus strand
chr17:40,177,594-40,217,383
(GRCh37/hg19)
Size:
39,790 bases
Orientation:
Minus strand

Genomic View for ZNF385C Gene

Genes around ZNF385C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF385C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF385C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF385C Gene

Proteins for ZNF385C Gene

  • Protein details for ZNF385C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q66K41-Z385C_HUMAN
    Recommended name:
    Zinc finger protein 385C
    Protein Accession:
    Q66K41
    Secondary Accessions:
    • A0A087WX54
    • Q4G0J1

    Protein attributes for ZNF385C Gene

    Size:
    424 amino acids
    Molecular mass:
    44235 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF385C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF385C Gene

Post-translational modifications for ZNF385C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF385C Gene

No data available for DME Specific Peptides for ZNF385C Gene

Domains & Families for ZNF385C Gene

Gene Families for ZNF385C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ZNF385C Gene

Suggested Antigen Peptide Sequences for ZNF385C Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 385C (Z385C_HUMAN)
genes like me logo Genes that share domains with ZNF385C: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF385C Gene

Function for ZNF385C Gene

Phenotypes From GWAS Catalog for ZNF385C Gene

Gene Ontology (GO) - Molecular Function for ZNF385C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 21516116
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF385C: view

Phenotypes for ZNF385C Gene

genes like me logo Genes that share phenotypes with ZNF385C: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF385C Gene

Localization for ZNF385C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF385C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF385C gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ZNF385C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF385C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF385C Gene

Pathways & Interactions for ZNF385C Gene

PathCards logo

SuperPathways for ZNF385C Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF385C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF385C Gene

Drugs & Compounds for ZNF385C Gene

No Compound Related Data Available

Transcripts for ZNF385C Gene

mRNA/cDNA for ZNF385C Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF385C Gene

No ASD Table

Relevant External Links for ZNF385C Gene

GeneLoc Exon Structure for
ZNF385C
ECgene alternative splicing isoforms for
ZNF385C

Expression for ZNF385C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF385C Gene

mRNA differential expression in normal tissues according to GTEx for ZNF385C Gene

This gene is overexpressed in Testis (x9.5) and Brain - Cerebellum (x7.2).

Protein differential expression in normal tissues from HIPED for ZNF385C Gene

This gene is overexpressed in Breast (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF385C Gene



Protein tissue co-expression partners for ZNF385C Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF385C Gene:

ZNF385C

SOURCE GeneReport for Unigene cluster for ZNF385C Gene:

Hs.443140

Evidence on tissue expression from TISSUES for ZNF385C Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with ZNF385C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF385C Gene

Orthologs for ZNF385C Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF385C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF385C 33
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF385C 33
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF385C 33
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp385c 33
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF385C 33
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF385C 33
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF385C 33
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF385C 33
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii znf385c 33
  • 40 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 17 (a)
OneToMany
Species where no ortholog for ZNF385C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF385C Gene

ENSEMBL:
Gene Tree for ZNF385C (if available)
TreeFam:
Gene Tree for ZNF385C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF385C: view image

Paralogs for ZNF385C Gene

Paralogs for ZNF385C Gene

(4) SIMAP similar genes for ZNF385C Gene using alignment to 2 proteins:

  • Z385C_HUMAN
  • C9J6X6_HUMAN
genes like me logo Genes that share paralogs with ZNF385C: view

Variants for ZNF385C Gene

Sequence variations from dbSNP and Humsavar for ZNF385C Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000074571 -- 42,039,517(-) G/A upstream_transcript_variant
rs1000351650 -- 42,032,724(-) T/C intron_variant
rs1000854996 -- 42,027,278(-) A/G intron_variant
rs1001726298 -- 42,029,646(-) G/A intron_variant
rs1001860257 -- 42,028,643(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF385C Gene

Variant ID Type Subtype PubMed ID
nsv1056904 CNV gain 25217958
nsv1146669 OTHER inversion 26484159

Variation tolerance for ZNF385C Gene

Gene Damage Index Score: 1.71; 32.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF385C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF385C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF385C Gene

Disorders for ZNF385C Gene

Additional Disease Information for ZNF385C

No disorders were found for ZNF385C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF385C Gene

Publications for ZNF385C Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56
  2. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H … Vidal M (Nature methods 2011) 3 56
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 56
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 56
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R … Stanton LW (Nature biotechnology 2004) 3 56

Products for ZNF385C Gene

Sources for ZNF385C Gene