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Aliases for ZNF385A Gene

Aliases for ZNF385A Gene

  • Zinc Finger Protein 385A 2 3 5
  • Hematopoietic Zinc Finger Protein 3 4
  • Retinal Zinc Finger Protein 3 4
  • Zinc Finger Protein 385 2 3
  • ZNF385 3 4
  • RZF 3 4
  • HZF 3 4
  • ZFP385 3

External Ids for ZNF385A Gene

Previous HGNC Symbols for ZNF385A Gene

  • ZNF385

Previous GeneCards Identifiers for ZNF385A Gene

  • GC12M053050
  • GC12M054762
  • GC12M051802

Summaries for ZNF385A Gene

Entrez Gene Summary for ZNF385A Gene

  • Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or double-stranded RNA, or interact with other proteins (Sharma et al., 2004 [PubMed 15527981]).[supplied by OMIM, Oct 2008]

GeneCards Summary for ZNF385A Gene

ZNF385A (Zinc Finger Protein 385A) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and p53 binding. An important paralog of this gene is ZNF385B.

UniProtKB/Swiss-Prot for ZNF385A Gene

  • RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.

Additional gene information for ZNF385A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF385A Gene

Genomics for ZNF385A Gene

GeneHancer (GH) Regulatory Elements for ZNF385A Gene

Promoters and enhancers for ZNF385A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I054381 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 562.6 +4.6 4564 10.5 HDGF PKNOX1 CLOCK IRF4 FOS SP3 ZNF592 SMARCA4 GLIS1 ZNF624 ZNF385A GPR84 MAP3K12 MIR148B ITGA5 RNU6-950P COPZ1 GTSF1 FLJ12825 LOC102724050
GH12I054393 Enhancer 0.6 ENCODE dbSUPER 561 -0.8 -849 0.2 ZBTB33 ZBTB17 ZNF385A ITGA5 GPR84 MIR148B RNU6-950P COPZ1 GTSF1 GC12P054401 ENSG00000258086 LOC102724050
GH12I054407 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 32.3 -24.5 -24483 16.8 HDGF PKNOX1 SMAD1 SIN3A YBX1 YY1 POLR2B FOS SP3 REST ITGA5 GPR84 ZNF385A GTSF1 PHC1P1 MAP3K12 ENSG00000260470 CALCOCO1 NCKAP1L GC12P054401
GH12I054354 Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 25.2 +33.3 33303 6.6 FEZF1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF143 MCM3 SP3 NFYC SP1 PCBP2 ENSG00000258344 CBX5 GPR84 ZNF385A MAP3K12 ATF7 LOC100652999 HNRNPA1
GH12I054291 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 +94.2 94193 11.8 HDGF PKNOX1 SMAD1 ARNT ARID4B YBX1 DMAP1 ZNF2 POLR2B ZNF766 NFE2 HNRNPA1 RNU6-950P MIR148B GPR84 ZNF385A FLJ12825 GTSF1 AAAS COPZ1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF385A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF385A gene promoter:

Genomic Locations for ZNF385A Gene

Genomic Locations for ZNF385A Gene
chr12:54,369,129-54,391,305
(GRCh38/hg38)
Size:
22,177 bases
Orientation:
Minus strand
chr12:54,762,917-54,785,083
(GRCh37/hg19)

Genomic View for ZNF385A Gene

Genes around ZNF385A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF385A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF385A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF385A Gene

Proteins for ZNF385A Gene

  • Protein details for ZNF385A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PM9-Z385A_HUMAN
    Recommended name:
    Zinc finger protein 385A
    Protein Accession:
    Q96PM9
    Secondary Accessions:
    • B2RDN5
    • B4DKH2
    • F1T0F1
    • J3KNS3
    • Q5VH53
    • Q9H7R6
    • Q9UFU3

    Protein attributes for ZNF385A Gene

    Size:
    386 amino acids
    Molecular mass:
    40454 Da
    Quaternary structure:
    • Interacts with ELAVL1; the interaction is indirect, mRNA-dependent and may regulate p53/TP53 expression (By similarity). Interacts with p53/TP53; the interaction is direct and enhances p53/TP53 transactivation functions on cell-cycle arrest target genes, resulting in growth arrest.

    Alternative splice isoforms for ZNF385A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF385A Gene

Post-translational modifications for ZNF385A Gene

  • Ubiquitinated upon prolonged exposure to genotoxic stress, which leads to proteasomal degradation of ZNF385A and releases p53/TP53 from cell-cycle arrest target gene promoters.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF385A Gene

Domains & Families for ZNF385A Gene

Gene Families for ZNF385A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ZNF385A Gene

Suggested Antigen Peptide Sequences for ZNF385A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF385A: view

No data available for UniProtKB/Swiss-Prot for ZNF385A Gene

Function for ZNF385A Gene

Molecular function for ZNF385A Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.
UniProtKB/Swiss-Prot Induction:
Up-regulated by p53/TP53 in response to DNA damage and oxidative stress.

Phenotypes From GWAS Catalog for ZNF385A Gene

Gene Ontology (GO) - Molecular Function for ZNF385A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002039 p53 binding IPI 17719541
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IEA,HDA 22681889
GO:0003730 mRNA 3-UTR binding ISS --
genes like me logo Genes that share ontologies with ZNF385A: view
genes like me logo Genes that share phenotypes with ZNF385A: view

Animal Models for ZNF385A Gene

MGI Knock Outs for ZNF385A:

Animal Model Products

CRISPR Products

miRNA for ZNF385A Gene

miRTarBase miRNAs that target ZNF385A

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF385A Gene

Localization for ZNF385A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF385A Gene

Cytoplasm. Nucleus, nucleolus. Cell projection, dendrite. Note=Detected in dendrites of Purkinje cells and hippocampal neurons. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF385A gene
Compartment Confidence
nucleus 5
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF385A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 colocalizes_with nuclear chromatin IDA 17719541
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ZNF385A: view

Pathways & Interactions for ZNF385A Gene

genes like me logo Genes that share pathways with ZNF385A: view

Pathways by source for ZNF385A Gene

1 BioSystems pathway for ZNF385A Gene

Interacting Proteins for ZNF385A Gene

Gene Ontology (GO) - Biological Process for ZNF385A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006417 regulation of translation IEA --
GO:0006915 apoptotic process ISS --
GO:0006974 cellular response to DNA damage stimulus ISS --
genes like me logo Genes that share ontologies with ZNF385A: view

No data available for SIGNOR curated interactions for ZNF385A Gene

Drugs & Compounds for ZNF385A Gene

No Compound Related Data Available

Transcripts for ZNF385A Gene

Unigene Clusters for ZNF385A Gene

Zinc finger protein 385A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF385A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13a · 13b ^ 14 ^ 15a · 15b
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - - -
SP4: - - - -
SP5: - - - - - -
SP6: - -
SP7:
SP8: - - - - - - - -
SP9: - - - - - - -
SP10: - - - -
SP11: -
SP12: - - - - - - - - -
SP13: - - - -
SP14: - - - - -

Relevant External Links for ZNF385A Gene

GeneLoc Exon Structure for
ZNF385A
ECgene alternative splicing isoforms for
ZNF385A

Expression for ZNF385A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF385A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF385A Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x4.4).

Protein differential expression in normal tissues from HIPED for ZNF385A Gene

This gene is overexpressed in Lung (52.9) and Retina (14.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF385A Gene



Protein tissue co-expression partners for ZNF385A Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF385A Gene:

ZNF385A

SOURCE GeneReport for Unigene cluster for ZNF385A Gene:

Hs.505653

mRNA Expression by UniProt/SwissProt for ZNF385A Gene:

Q96PM9-Z385A_HUMAN
Tissue specificity: Expressed predominantly in the retina.

Evidence on tissue expression from TISSUES for ZNF385A Gene

  • Eye(4.6)
  • Thyroid gland(4.3)
  • Blood(4.1)
  • Liver(4.1)
  • Nervous system(3.4)
genes like me logo Genes that share expression patterns with ZNF385A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF385A Gene

Orthologs for ZNF385A Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF385A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF385A 33 34
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia ZNF385A 33 34
  • 93.87 (n)
rat
(Rattus norvegicus)
Mammalia Zfp385a 33
  • 92.06 (n)
dog
(Canis familiaris)
Mammalia ZNF385A 33 34
  • 91.97 (n)
mouse
(Mus musculus)
Mammalia Zfp385a 33 16 34
  • 91.8 (n)
chicken
(Gallus gallus)
Aves -- 34
  • 49 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ZNF385A 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf385a 33
  • 62.58 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100147851 33
  • 64.97 (n)
znf385a 34
  • 54 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 17 (a)
OneToMany
Species where no ortholog for ZNF385A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF385A Gene

ENSEMBL:
Gene Tree for ZNF385A (if available)
TreeFam:
Gene Tree for ZNF385A (if available)

Paralogs for ZNF385A Gene

Paralogs for ZNF385A Gene

genes like me logo Genes that share paralogs with ZNF385A: view

Variants for ZNF385A Gene

Sequence variations from dbSNP and Humsavar for ZNF385A Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000302355 -- 54,388,056(-) T/A genic_upstream_transcript_variant, intron_variant
rs1000456155 -- 54,376,596(-) T/C intron_variant
rs1000608681 -- 54,383,721(-) C/A intron_variant
rs1000674342 -- 54,369,335(-) G/A 3_prime_UTR_variant
rs1000719261 -- 54,374,352(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF385A Gene

Variant ID Type Subtype PubMed ID
esv995599 CNV deletion 20482838
nsv1070112 CNV deletion 25765185
nsv474052 CNV novel sequence insertion 20440878
nsv559000 CNV loss 21841781

Variation tolerance for ZNF385A Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.67; 14.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF385A Gene

Human Gene Mutation Database (HGMD)
ZNF385A
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF385A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF385A Gene

Disorders for ZNF385A Gene

Additional Disease Information for ZNF385A

No disorders were found for ZNF385A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF385A Gene

Publications for ZNF385A Gene

  1. RZF, a zinc-finger protein in the photoreceptors of human retina. (PMID: 15527981) Sharma S … Della NG (Gene 2004) 3 4 22 58
  2. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M … Kato S (Investigative ophthalmology & visual science 2011) 3 4 58
  3. Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation. (PMID: 17719541) Das S … Lee SW (Cell 2007) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for ZNF385A Gene

Sources for ZNF385A Gene

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