Aliases for ZNF384 Gene
External Ids for ZNF384 Gene
Previous HGNC Symbols for ZNF384 Gene
Previous GeneCards Identifiers for ZNF384 Gene
This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011]
GeneCards Summary for ZNF384 Gene
ZNF384 (Zinc Finger Protein 384) is a Protein Coding gene. Diseases associated with ZNF384 include Ewing Sarcoma and Acute Leukemia. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and SH3 domain binding. An important paralog of this gene is ZNF362.
UniProtKB/Swiss-Prot Summary for ZNF384 Gene
Transcription factor that binds the consensus DNA sequence [GC]AAAAA. Seems to bind and regulate the promoters of MMP1, MMP3, MMP7 and COL1A1 (By similarity).