The protein encoded by this gene is a KRAB-related zinc finger protein that inhibits the transcription of some MAPK signaling pathway genes. The repressor activity resides in the KRAB domain of the encoded protein. [provided by RefSeq, Sep 2016] See more...

Aliases for ZNF383 Gene

Aliases for ZNF383 Gene

  • Zinc Finger Protein 383 2 3 4 5
  • Zfp383 3
  • HSD17 3

External Ids for ZNF383 Gene

Previous GeneCards Identifiers for ZNF383 Gene

  • GC19P042410
  • GC19P042411
  • GC19P037709
  • GC19P034186

Summaries for ZNF383 Gene

Entrez Gene Summary for ZNF383 Gene

  • The protein encoded by this gene is a KRAB-related zinc finger protein that inhibits the transcription of some MAPK signaling pathway genes. The repressor activity resides in the KRAB domain of the encoded protein. [provided by RefSeq, Sep 2016]

GeneCards Summary for ZNF383 Gene

ZNF383 (Zinc Finger Protein 383) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF829.

UniProtKB/Swiss-Prot Summary for ZNF383 Gene

  • May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.

Additional gene information for ZNF383 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF383 Gene

Genomics for ZNF383 Gene

GeneHancer (GH) Regulatory Elements for ZNF383 Gene

Promoters and enhancers for ZNF383 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF383 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF383

Top Transcription factor binding sites by QIAGEN in the ZNF383 gene promoter:
  • AP-1
  • Arnt
  • ATF-2
  • c-Fos
  • c-Jun
  • HOXA5
  • MRF-2
  • Pax-3

Genomic Locations for ZNF383 Gene

Genomic Locations for ZNF383 Gene
chr19:37,217,926-37,248,738
(GRCh38/hg38)
Size:
30,813 bases
Orientation:
Plus strand
chr19:37,708,828-37,734,828
(GRCh37/hg19)
Size:
26,001 bases
Orientation:
Plus strand

Genomic View for ZNF383 Gene

Genes around ZNF383 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF383 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF383 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF383 Gene

Proteins for ZNF383 Gene

  • Protein details for ZNF383 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NA42-ZN383_HUMAN
    Recommended name:
    Zinc finger protein 383
    Protein Accession:
    Q8NA42
    Secondary Accessions:
    • Q6X2C7

    Protein attributes for ZNF383 Gene

    Size:
    475 amino acids
    Molecular mass:
    54613 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF383 Gene

Post-translational modifications for ZNF383 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF383 Gene

Domains & Families for ZNF383 Gene

Gene Families for ZNF383 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF383 Gene

Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF383 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 383 (ZN383_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8NA42

UniProtKB/Swiss-Prot:

ZN383_HUMAN :
  • The KRAB domain is responsible for the transcriptional repressor activity.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The KRAB domain is responsible for the transcriptional repressor activity.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF383: view

Function for ZNF383 Gene

Molecular function for ZNF383 Gene

UniProtKB/Swiss-Prot Function:
May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.

Phenotypes From GWAS Catalog for ZNF383 Gene

Gene Ontology (GO) - Molecular Function for ZNF383 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF383: view
genes like me logo Genes that share phenotypes with ZNF383: view

miRNA for ZNF383 Gene

miRTarBase miRNAs that target ZNF383

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF383 Gene

Localization for ZNF383 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF383 Gene

Nucleus. Cytoplasm. Note=Shuttling between the nucleus and cytoplasm may occur under different stimulation and growth conditions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF383 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF383 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with ZNF383: view

Pathways & Interactions for ZNF383 Gene

genes like me logo Genes that share pathways with ZNF383: view

Pathways by source for ZNF383 Gene

2 Reactome pathways for ZNF383 Gene
1 KEGG pathway for ZNF383 Gene

Interacting Proteins for ZNF383 Gene

;

Gene Ontology (GO) - Biological Process for ZNF383 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF383: view

No data available for SIGNOR curated interactions for ZNF383 Gene

Drugs & Compounds for ZNF383 Gene

No Compound Related Data Available

Transcripts for ZNF383 Gene

mRNA/cDNA for ZNF383 Gene

4 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF383 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for ZNF383 Gene

GeneLoc Exon Structure for
ZNF383

Expression for ZNF383 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF383 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF383

SOURCE GeneReport for Unigene cluster for ZNF383 Gene:

Hs.590975

mRNA Expression by UniProt/SwissProt for ZNF383 Gene:

Q8NA42-ZN383_HUMAN
Tissue specificity: Expressed in heart, placenta, liver, pancreas and with a higher level in skeletal muscle.
genes like me logo Genes that share expression patterns with ZNF383: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF383 Gene

Orthologs for ZNF383 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF383 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF420 30
  • 99.51 (n)
ZNF383 31
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF383 31 30
  • 93.8 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp383 17 30
  • 84.99 (n)
chicken
(Gallus gallus)
Aves LOC100858932 30
  • 57.83 (n)
Species where no ortholog for ZNF383 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF383 Gene

ENSEMBL:
Gene Tree for ZNF383 (if available)
TreeFam:
Gene Tree for ZNF383 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF383: view image

Paralogs for ZNF383 Gene

Paralogs for ZNF383 Gene

(506) SIMAP similar genes for ZNF383 Gene using alignment to 3 proteins:

  • ZN383_HUMAN
  • K7EJN0_HUMAN
  • K7ELW4_HUMAN

Pseudogenes.org Pseudogenes for ZNF383 Gene

genes like me logo Genes that share paralogs with ZNF383: view

Variants for ZNF383 Gene

Additional dbSNP identifiers (rs#s) for ZNF383 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF383 Gene

Variant ID Type Subtype PubMed ID
esv1445664 CNV insertion 17803354
esv1570552 CNV insertion 17803354
esv2580999 CNV insertion 19546169
esv3408256 CNV duplication 20981092
nsv579461 CNV gain 21841781
nsv9717 CNV gain+loss 18304495

Variation tolerance for ZNF383 Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF383 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF383

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF383 Gene

Disorders for ZNF383 Gene

Additional Disease Information for ZNF383

No disorders were found for ZNF383 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF383 Gene

Publications for ZNF383 Gene

  1. ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway. (PMID: 15964543) Cao L … Liu M (Biochemical and biophysical research communications 2005) 3 4 23 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PMID: 23870195) Wojczynski MK … Reilly MP (BMC medical genetics 2013) 3 54
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 54
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T … Hayashizaki Y (Cell 2010) 3 54

Products for ZNF383 Gene