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Aliases for ZNF383 Gene

Aliases for ZNF383 Gene

  • Zinc Finger Protein 383 2 3 5
  • HSD17 3

External Ids for ZNF383 Gene

Previous GeneCards Identifiers for ZNF383 Gene

  • GC19P042410
  • GC19P042411
  • GC19P037709
  • GC19P034186

Summaries for ZNF383 Gene

Entrez Gene Summary for ZNF383 Gene

  • The protein encoded by this gene is a KRAB-related zinc finger protein that inhibits the transcription of some MAPK signaling pathway genes. The repressor activity resides in the KRAB domain of the encoded protein. [provided by RefSeq, Sep 2016]

GeneCards Summary for ZNF383 Gene

ZNF383 (Zinc Finger Protein 383) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF829.

UniProtKB/Swiss-Prot for ZNF383 Gene

  • May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.

Additional gene information for ZNF383 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF383 Gene

Genomics for ZNF383 Gene

GeneHancer (GH) Regulatory Elements for ZNF383 Gene

Promoters and enhancers for ZNF383 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I037217 Promoter/Enhancer 1.6 Ensembl ENCODE 655.6 +0.3 349 2.2 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 POLR2B ZNF383 ZNF585B ZNF345 ZNF850 ZNF529 ZFP82 ZNF527 ZNF540 ZNF793 ZNF567
GH19I037466 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 211.5 +250.3 250289 4.4 FEZF1 DMAP1 IRF4 YY1 ZNF213 ZNF416 ZNF143 ZNF548 SP3 ZC3H11A ZNF570 ZNF569 ZNF567 ZNF345 ZNF383 ZNF527 ZNF850 ZNF571 ZNF585B HKR1
GH19I037653 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 199.1 +437.4 437374 3 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 ZNF416 ZNF143 ZNF548 SP3 ZFP30 ZNF527 ZNF567 ZNF383 ZNF345 ZNF571 ZNF790 HKR1 ZNF850 ZNF585A
GH19I037370 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 187.6 +153.1 153114 1.9 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF213 ZNF527 ZNF567 ZNF383 ZNF345 ZFP30 ZNF571 HKR1 ZNF850 ZNF793 ZNF790
GH19I037593 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 176.7 +376.8 376775 2.2 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 SLC30A9 ZNF213 ZNF571 ZNF540 ZNF567 ZNF527 ZFP30 ZNF383 HKR1 ZNF345 ZNF585A ZNF607
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF383 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF383 gene promoter:

Genomic Locations for ZNF383 Gene

Genomic Locations for ZNF383 Gene
chr19:37,217,926-37,248,738
(GRCh38/hg38)
Size:
30,813 bases
Orientation:
Plus strand
chr19:37,708,828-37,734,828
(GRCh37/hg19)

Genomic View for ZNF383 Gene

Genes around ZNF383 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF383 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF383 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF383 Gene

Proteins for ZNF383 Gene

  • Protein details for ZNF383 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NA42-ZN383_HUMAN
    Recommended name:
    Zinc finger protein 383
    Protein Accession:
    Q8NA42
    Secondary Accessions:
    • Q6X2C7

    Protein attributes for ZNF383 Gene

    Size:
    475 amino acids
    Molecular mass:
    54613 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF383 Gene

Post-translational modifications for ZNF383 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF383 Gene

Domains & Families for ZNF383 Gene

Gene Families for ZNF383 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF383 Gene

Suggested Antigen Peptide Sequences for ZNF383 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NA42

UniProtKB/Swiss-Prot:

ZN383_HUMAN :
  • The KRAB domain is responsible for the transcriptional repressor activity.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • The KRAB domain is responsible for the transcriptional repressor activity.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF383: view

Function for ZNF383 Gene

Molecular function for ZNF383 Gene

UniProtKB/Swiss-Prot Function:
May function as a transcriptional repressor, suppressing transcriptional activities mediated by MAPK signaling pathways.

Phenotypes From GWAS Catalog for ZNF383 Gene

Gene Ontology (GO) - Molecular Function for ZNF383 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF383: view
genes like me logo Genes that share phenotypes with ZNF383: view

miRNA for ZNF383 Gene

miRTarBase miRNAs that target ZNF383

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF383 Gene

Localization for ZNF383 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF383 Gene

Nucleus. Cytoplasm. Note=Shuttling between the nucleus and cytoplasm may occur under different stimulation and growth conditions.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF383 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF383 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with ZNF383: view

Pathways & Interactions for ZNF383 Gene

SuperPathways for ZNF383 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF383: view

Pathways by source for ZNF383 Gene

2 Reactome pathways for ZNF383 Gene

Gene Ontology (GO) - Biological Process for ZNF383 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
genes like me logo Genes that share ontologies with ZNF383: view

No data available for SIGNOR curated interactions for ZNF383 Gene

Drugs & Compounds for ZNF383 Gene

No Compound Related Data Available

Transcripts for ZNF383 Gene

Unigene Clusters for ZNF383 Gene

Zinc finger protein 383:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF383 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6:

Relevant External Links for ZNF383 Gene

GeneLoc Exon Structure for
ZNF383
ECgene alternative splicing isoforms for
ZNF383

Expression for ZNF383 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF383 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF383 Gene:

ZNF383

SOURCE GeneReport for Unigene cluster for ZNF383 Gene:

Hs.590975

mRNA Expression by UniProt/SwissProt for ZNF383 Gene:

Q8NA42-ZN383_HUMAN
Tissue specificity: Expressed in heart, placenta, liver, pancreas and with a higher level in skeletal muscle.
genes like me logo Genes that share expression patterns with ZNF383: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF383 Gene

Orthologs for ZNF383 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF383 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF420 33
  • 99.51 (n)
ZNF383 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF383 33 34
  • 93.8 (n)
mouse
(Mus musculus)
Mammalia Zfp383 33 16
  • 84.99 (n)
chicken
(Gallus gallus)
Aves LOC100858932 33
  • 57.83 (n)
Species where no ortholog for ZNF383 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF383 Gene

ENSEMBL:
Gene Tree for ZNF383 (if available)
TreeFam:
Gene Tree for ZNF383 (if available)

Paralogs for ZNF383 Gene

(506) SIMAP similar genes for ZNF383 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ZNF383 Gene

genes like me logo Genes that share paralogs with ZNF383: view

Variants for ZNF383 Gene

Sequence variations from dbSNP and Humsavar for ZNF383 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000051839 -- 37,220,425(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000083133 -- 37,244,820(+) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000159617 -- 37,220,967(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000324243 -- 37,233,215(+) C/G intron_variant
rs1000351940 -- 37,227,345(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF383 Gene

Variant ID Type Subtype PubMed ID
esv1445664 CNV insertion 17803354
esv1570552 CNV insertion 17803354
esv2580999 CNV insertion 19546169
esv3408256 CNV duplication 20981092
nsv579461 CNV gain 21841781
nsv9717 CNV gain+loss 18304495

Variation tolerance for ZNF383 Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF383 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF383

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF383 Gene

Disorders for ZNF383 Gene

Additional Disease Information for ZNF383

No disorders were found for ZNF383 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF383 Gene

Publications for ZNF383 Gene

  1. ZNF383, a novel KRAB-containing zinc finger protein, suppresses MAPK signaling pathway. (PMID: 15964543) Cao L … Liu M (Biochemical and biophysical research communications 2005) 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PMID: 23870195) Wojczynski MK … Reilly MP (BMC medical genetics 2013) 3 58
  4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. (PMID: 22658674) Castello A … Hentze MW (Cell 2012) 3 58
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T … Hayashizaki Y (Cell 2010) 3 58

Products for ZNF383 Gene

Sources for ZNF383 Gene

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