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Aliases for ZNF382 Gene

Aliases for ZNF382 Gene

  • Zinc Finger Protein 382 2 3 5
  • Multiple Zinc Finger And Krueppel-Associated Box Protein KS1 3 4
  • KRAB/Zinc Finger Suppressor Protein 1 3 4
  • KS1 3 4

External Ids for ZNF382 Gene

Previous GeneCards Identifiers for ZNF382 Gene

  • GC19P037556
  • GC19P041771
  • GC19P041790
  • GC19P041791
  • GC19P041793
  • GC19P037095
  • GC19P033564
  • GC19P036608

Summaries for ZNF382 Gene

Entrez Gene Summary for ZNF382 Gene

  • This gene encodes a KRAB domain zinc finger transcription factor (KZNF). KZNFs play critical roles in the regulation of many cellular processes including differentiation, proliferation and apoptosis. The encoded protein inhibits activating protein 1 (AP-1) and nuclear factor kappa-B (NF-kB) signaling and may function as a tumor suppressor in multiple carcinomas. This gene is found in a cluster with other zinc finger protein genes on the long arm of chromosome 19, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for ZNF382 Gene

ZNF382 (Zinc Finger Protein 382) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF567.

UniProtKB/Swiss-Prot for ZNF382 Gene

  • Functions as a sequence-specific transcriptional repressor.

Additional gene information for ZNF382 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF382 Gene

Genomics for ZNF382 Gene

GeneHancer (GH) Regulatory Elements for ZNF382 Gene

Promoters and enhancers for ZNF382 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I036604 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.5 498 2.4 HDGF PKNOX1 ARID4B FEZF1 DMAP1 ZNF2 ZNF213 ZNF416 ZNF143 ZNF548 ZNF529 ZNF382 ZNF383 ZNF567 ZNF345 ZNF850 HKR1 ZNF527 ZNF585B ZNF571
GH19I037370 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 58.7 +766.2 766223 1.9 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF213 ZNF527 ZNF567 ZNF383 ZNF345 ZFP30 ZNF571 HKR1 ZNF850 ZNF793 ZNF790
GH19I037593 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 53.6 +989.9 989884 2.2 PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 YY1 SLC30A9 ZNF213 ZNF571 ZNF540 ZNF567 ZNF527 ZFP30 ZNF383 HKR1 ZNF345 ZNF585A ZNF607
GH19I036915 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 37.7 +311.7 311678 2.2 PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF302 ZNF416 ZNF143 ZNF548 SP3 ZNF568 ZNF829 GC19M038851 ZNF527 ZNF567 ZNF345 ZNF383 ZFP30 ZNF571 ZNF850
GH19I035710 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.7 -889.6 -889624 10 ZFP64 DMAP1 IRF4 YY1 ZNF213 ZNF143 ZNF548 ZNF263 SP3 ZFP41 KMT2B ZBTB32 PIR52641 ZNF529 ZNF567 ZNF461 TMEM147-AS1 ZNF599 LINC01534 ZFP82
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF382 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF382 gene promoter:

Genomic Locations for ZNF382 Gene

Genomic Locations for ZNF382 Gene
29,297 bases
Plus strand

Genomic View for ZNF382 Gene

Genes around ZNF382 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF382 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF382 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF382 Gene

Proteins for ZNF382 Gene

  • Protein details for ZNF382 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 382
    Protein Accession:
    Secondary Accessions:
    • A3KMP6
    • A8MT55
    • C9K0V5
    • Q53ZY8
    • Q5JPJ2

    Protein attributes for ZNF382 Gene

    550 amino acids
    Molecular mass:
    64010 Da
    Quaternary structure:
    • Interacts with TRIM28; enhances the transcriptional repressor activity.

    Alternative splice isoforms for ZNF382 Gene


neXtProt entry for ZNF382 Gene

Post-translational modifications for ZNF382 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF382 Gene

Domains & Families for ZNF382 Gene

Gene Families for ZNF382 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for ZNF382 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF382: view

Function for ZNF382 Gene

Molecular function for ZNF382 Gene

UniProtKB/Swiss-Prot Function:
Functions as a sequence-specific transcriptional repressor.

Phenotypes From GWAS Catalog for ZNF382 Gene

Gene Ontology (GO) - Molecular Function for ZNF382 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0044212 transcription regulatory region DNA binding IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF382: view
genes like me logo Genes that share phenotypes with ZNF382: view
Targeted motifs for ZNF382 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF382
  • Consensus sequence: GNCTGTASTRNTGBCTCHTT Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF382 Gene

Localization for ZNF382 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF382 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF382 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF382 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF382: view

Pathways & Interactions for ZNF382 Gene

SuperPathways for ZNF382 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF382: view

Pathways by source for ZNF382 Gene

2 Reactome pathways for ZNF382 Gene

Gene Ontology (GO) - Biological Process for ZNF382 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA --
genes like me logo Genes that share ontologies with ZNF382: view

No data available for SIGNOR curated interactions for ZNF382 Gene

Drugs & Compounds for ZNF382 Gene

No Compound Related Data Available

Transcripts for ZNF382 Gene

mRNA/cDNA for ZNF382 Gene

Unigene Clusters for ZNF382 Gene

Zinc finger protein 382:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF382 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - -
SP2: - - - - -
SP3: -

Relevant External Links for ZNF382 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF382 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF382 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF382 Gene

This gene is overexpressed in Brain - Cerebellum (x7.2) and Brain - Cerebellar Hemisphere (x6.7).

NURSA nuclear receptor signaling pathways regulating expression of ZNF382 Gene:


SOURCE GeneReport for Unigene cluster for ZNF382 Gene:


mRNA Expression by UniProt/SwissProt for ZNF382 Gene:

Tissue specificity: Specifically expressed in heart with a weaker expression also detected in skeletal muscle.

Evidence on tissue expression from TISSUES for ZNF382 Gene

  • Nervous system(4.2)
  • Lymph node(4.1)
genes like me logo Genes that share expression patterns with ZNF382: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF382 Gene

Orthologs for ZNF382 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF382 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF382 33 34
  • 99.82 (n)
(Bos Taurus)
Mammalia ZNF382 33 34
  • 90.1 (n)
(Mus musculus)
Mammalia Zfp382 33 16 34
  • 80.04 (n)
(Rattus norvegicus)
Mammalia Zfp382 33
  • 79.47 (n)
(Canis familiaris)
Mammalia ZNF382 34
  • 75 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 32 (a)
Species where no ortholog for ZNF382 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF382 Gene

Gene Tree for ZNF382 (if available)
Gene Tree for ZNF382 (if available)

Paralogs for ZNF382 Gene

(512) SIMAP similar genes for ZNF382 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ZNF382: view

Variants for ZNF382 Gene

Sequence variations from dbSNP and Humsavar for ZNF382 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000181299 -- 36,626,625(+) A/G coding_sequence_variant, missense_variant
rs1000184853 -- 36,606,121(+) T/G intron_variant
rs1000237346 -- 36,605,881(+) T/C intron_variant
rs1000539433 -- 36,612,706(+) A/G intron_variant
rs1000705152 -- 36,607,192(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF382 Gene

Variant ID Type Subtype PubMed ID
nsv1064851 CNV loss 25217958
nsv833817 CNV loss 17160897

Variation tolerance for ZNF382 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.96; 68.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF382 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF382 Gene

Disorders for ZNF382 Gene

Additional Disease Information for ZNF382

No disorders were found for ZNF382 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF382 Gene

Publications for ZNF382 Gene

  1. Expression of a novel Krüpple-like zinc-finger gene, ZNF382, in human heart. (PMID: 12459182) Luo K … Wu X (Biochemical and biophysical research communications 2002) 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Interactome of the negative regulator of nuclear import BRCA1-binding protein 2. (PMID: 25820252) Fatima S … Jans DA (Scientific reports 2015) 3 58
  4. Zinc finger protein 382 is downregulated by promoter hypermethylation in pediatric acute myeloid leukemia patients. (PMID: 25319049) Tao YF … Pan J (International journal of molecular medicine 2014) 3 58
  5. Large-scale characterization of DNA methylation changes in human gastric carcinomas with and without metastasis. (PMID: 25009298) Liu Z … Deng D (Clinical cancer research : an official journal of the American Association for Cancer Research 2014) 3 58

Products for ZNF382 Gene

Sources for ZNF382 Gene

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