This gene encodes a KRAB domain zinc finger transcription factor (KZNF). KZNFs play critical roles in the regulation of many cellular processes including differentiation, proliferation and apoptosis. The encoded protein inhibits activating protein 1 (AP-1) and nuclear factor kappa-B (NF-kB) signaling and may function as a tumor suppressor in multiple carcinomas. This gene is fo... See more...

Aliases for ZNF382 Gene

Aliases for ZNF382 Gene

  • Zinc Finger Protein 382 2 3 4 5
  • KS1 2 3 4
  • Multiple Zinc Finger And Krueppel-Associated Box Protein KS1 3 4
  • KRAB/Zinc Finger Suppressor Protein 1 3 4
  • FLJ14686 2
  • ZNF382 5

External Ids for ZNF382 Gene

Previous GeneCards Identifiers for ZNF382 Gene

  • GC19P037556
  • GC19P041771
  • GC19P041790
  • GC19P041791
  • GC19P041793
  • GC19P037095
  • GC19P033564
  • GC19P036608
  • GC19P037076
  • GC19P037246
  • GC19P037318
  • GC19P037751
  • GC19P036609
  • GC19P036768
  • GC19P036915

Summaries for ZNF382 Gene

Entrez Gene Summary for ZNF382 Gene

  • This gene encodes a KRAB domain zinc finger transcription factor (KZNF). KZNFs play critical roles in the regulation of many cellular processes including differentiation, proliferation and apoptosis. The encoded protein inhibits activating protein 1 (AP-1) and nuclear factor kappa-B (NF-kB) signaling and may function as a tumor suppressor in multiple carcinomas. This gene is found in a cluster with other zinc finger protein genes on the long arm of chromosome 19, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for ZNF382 Gene

ZNF382 (Zinc Finger Protein 382) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF567.

UniProtKB/Swiss-Prot Summary for ZNF382 Gene

Additional gene information for ZNF382 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF382 Gene

Genomics for ZNF382 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF382 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF382 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF382

Top Transcription factor binding sites by QIAGEN in the ZNF382 gene promoter:
  • AhR
  • aMEF-2
  • Arnt
  • Egr-2
  • Egr-3
  • FAC1
  • MEF-2
  • MEF-2A
  • Nkx2-5

Genomic Locations for ZNF382 Gene

Genomic Locations for ZNF382 Gene
chr19:36,604,817-36,634,114
(GRCh38/hg38)
Size:
29,298 bases
Orientation:
Plus strand
chr19:37,095,719-37,119,499
(GRCh37/hg19)
Size:
23,781 bases
Orientation:
Plus strand

Genomic View for ZNF382 Gene

Genes around ZNF382 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF382 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF382 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF382 Gene

Proteins for ZNF382 Gene

  • Protein details for ZNF382 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SR6-ZN382_HUMAN
    Recommended name:
    Zinc finger protein 382
    Protein Accession:
    Q96SR6
    Secondary Accessions:
    • A3KMP6
    • A8MT55
    • C9K0V5
    • Q53ZY8
    • Q5JPJ2

    Protein attributes for ZNF382 Gene

    Size:
    550 amino acids
    Molecular mass:
    64010 Da
    Quaternary structure:
    • Interacts with TRIM28; enhances the transcriptional repressor activity.

    Alternative splice isoforms for ZNF382 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF382 Gene

Post-translational modifications for ZNF382 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF382 Gene

Domains & Families for ZNF382 Gene

Gene Families for ZNF382 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF382 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF382 Gene

GenScript: Design optimal peptide antigens:
  • Multiple zinc finger and krueppel-associated box protein KS1 (ZN382_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96SR6

UniProtKB/Swiss-Prot:

ZN382_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF382: view

Function for ZNF382 Gene

Molecular function for ZNF382 Gene

UniProtKB/Swiss-Prot Function:
Functions as a sequence-specific transcriptional repressor.

Phenotypes From GWAS Catalog for ZNF382 Gene

Gene Ontology (GO) - Molecular Function for ZNF382 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with ZNF382: view
genes like me logo Genes that share phenotypes with ZNF382: view

Animal Model Products

CRISPR Products

Targeted motifs for ZNF382 Gene
HOMER Transcription Factor Regulatory Elements motif ZNF382
  • Consensus sequence: GNCTGTASTRNTGBCTCHTT Submotif: canonical Cell Type: HEK293 GEO ID: GSE58341

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF382

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and Transcription Factor Targets for ZNF382 Gene

Localization for ZNF382 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF382 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF382 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF382 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IBA 21873635
genes like me logo Genes that share ontologies with ZNF382: view

Pathways & Interactions for ZNF382 Gene

genes like me logo Genes that share pathways with ZNF382: view

Pathways by source for ZNF382 Gene

2 Reactome pathways for ZNF382 Gene
1 KEGG pathway for ZNF382 Gene

SIGNOR curated interactions for ZNF382 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for ZNF382 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF382: view

Drugs & Compounds for ZNF382 Gene

No Compound Related Data Available

Transcripts for ZNF382 Gene

mRNA/cDNA for ZNF382 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF382

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF382 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - - -
SP2: - - - - -
SP3: -
SP4:

Relevant External Links for ZNF382 Gene

GeneLoc Exon Structure for
ZNF382

Expression for ZNF382 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF382 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF382 Gene

This gene is overexpressed in Brain - Cerebellum (x7.2) and Brain - Cerebellar Hemisphere (x6.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF382

SOURCE GeneReport for Unigene cluster for ZNF382 Gene:

Hs.631591

mRNA Expression by UniProt/SwissProt for ZNF382 Gene:

Q96SR6-ZN382_HUMAN
Tissue specificity: Specifically expressed in heart with a weaker expression also detected in skeletal muscle.

Evidence on tissue expression from TISSUES for ZNF382 Gene

  • Nervous system(4.3)
  • Lymph node(4.2)
genes like me logo Genes that share expression patterns with ZNF382: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF382 Gene

Orthologs for ZNF382 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF382 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF382 30 31
  • 99.82 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF382 30 31
  • 90.1 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Zfp382 30 17 31
  • 80.04 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp382 30
  • 79.47 (n)
Dog
(Canis familiaris)
Mammalia ZNF382 31
  • 75 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 32 (a)
OneToMany
Species where no ortholog for ZNF382 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF382 Gene

ENSEMBL:
Gene Tree for ZNF382 (if available)
TreeFam:
Gene Tree for ZNF382 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF382: view image

Paralogs for ZNF382 Gene

(512) SIMAP similar genes for ZNF382 Gene using alignment to 5 proteins:

  • ZN382_HUMAN
  • C9JME7_HUMAN
  • K7EK67_HUMAN
  • K7EQ52_HUMAN
  • L0R6T6_HUMAN
genes like me logo Genes that share paralogs with ZNF382: view

Variants for ZNF382 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF382 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs3108171 - p.Glu168Gly

Additional dbSNP identifiers (rs#s) for ZNF382 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF382 Gene

Variant ID Type Subtype PubMed ID
nsv1064851 CNV loss 25217958
nsv833817 CNV loss 17160897

Variation tolerance for ZNF382 Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.96; 68.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF382 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF382

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF382 Gene

Disorders for ZNF382 Gene

No disorders were found for ZNF382 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF382 Gene

Publications for ZNF382 Gene

  1. Expression of a novel Krüpple-like zinc-finger gene, ZNF382, in human heart. (PMID: 12459182) Luo K … Wu X (Biochemical and biophysical research communications 2002) 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. ZNF382: A transcription inhibitor down-regulated in multiple tumors due to promoter methylation. (PMID: 31678273) Chen S … Zeng X (Clinica chimica acta; international journal of clinical chemistry 2020) 3
  4. Dynamic expression of ZNF382 and its tumor-suppressor role in hepatitis B virus-related hepatocellular carcinogenesis. (PMID: 30804458) Dang S … Hou P (Oncogene 2019) 3
  5. KRAB zinc-finger protein 382 regulates epithelial-mesenchymal transition and functions as a tumor suppressor, but is silenced by CpG methylation in gastric cancer. (PMID: 29956735) Pei L … Xiang T (International journal of oncology 2018) 3

Products for ZNF382 Gene

Sources for ZNF382 Gene