Aliases for ZNF37A Gene

Aliases for ZNF37A Gene

  • Zinc Finger Protein 37A 2 3 4 5
  • KOX21 2 3 4
  • ZNF37 2 3 4
  • Zinc Finger Protein 37a (KOX 21) 2 3
  • Zinc Finger Protein KOX21 3 4
  • ZNF37A 5

External Ids for ZNF37A Gene

Previous GeneCards Identifiers for ZNF37A Gene

  • GC10P038130
  • GC10P038323
  • GC10P038190
  • GC10P038387
  • GC10P038423
  • GC10P038383

Summaries for ZNF37A Gene

GeneCards Summary for ZNF37A Gene

ZNF37A (Zinc Finger Protein 37A) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF782.

UniProtKB/Swiss-Prot Summary for ZNF37A Gene

Gene Wiki entry for ZNF37A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF37A Gene

Genomics for ZNF37A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF37A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J038093 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 616.1 +0.2 174 2.6 HNRNPL CREB1 SIX5 ZNF692 POLR2A TARDBP FOXA1 ZNF143 ZIC2 RBFOX2 ZNF37A ENSG00000283930 lnc-ZNF33A-6 ENSG00000272983 CICP9 HSD17B7P2 ZNF248 ZNF25 SLC9B1P3 piR-38423-004
GH10J037975 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 1.8 -118.0 -118027 2.6 HNRNPL CREB1 GATAD2A CTCF ATF7 ZNF629 SIX5 NFKBIZ ZNF692 POLR2A ZNF25 ZNF248 ZNF25-DT ZNF37A piR-57460-054
GH10J038054 Enhancer 0.7 Ensembl ENCODE 3.9 -39.9 -39878 1.3 CEBPB ZNF316 FOS TRIM24 EP300 MAFK ATF4 ZNF248 ZNF37A piR-30293-001 RNU6-795P ZNF33A
GH10J037535 Enhancer 0.5 ENCODE 4.6 -558.3 -558265 1.8 SOX13 SP1 MAFF SMARCA4 MAFK ZNF25 HSD17B7P2 LINC00993 ZNF37A piR-38352-050 piR-48553-033 TACC1P1 MTRNR2L7 ANKRD30A
GH10J038036 Enhancer 0.2 FANTOM5 2.1 -57.7 -57682 0.3 ZNF37A ZNF25 RNU6-795P ZNF33A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF37A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF37A

Top Transcription factor binding sites by QIAGEN in the ZNF37A gene promoter:
  • AML1a
  • ATF6
  • CUTL1
  • FAC1
  • GATA-2
  • Nkx2-5
  • POU2F1
  • POU2F1a

Genomic Locations for ZNF37A Gene

Genomic Locations for ZNF37A Gene
55,967 bases
Plus strand
31,209 bases
Plus strand

Genomic View for ZNF37A Gene

Genes around ZNF37A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF37A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF37A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF37A Gene

Proteins for ZNF37A Gene

  • Protein details for ZNF37A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 37A
    Protein Accession:
    Secondary Accessions:
    • B3KRQ3
    • D3DRZ3
    • Q96B88

    Protein attributes for ZNF37A Gene

    561 amino acids
    Molecular mass:
    65418 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF37A Gene

Post-translational modifications for ZNF37A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF37A Gene

Domains & Families for ZNF37A Gene

Gene Families for ZNF37A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF37A Gene

  • C2H2-type zinc finger signature
  • KRAB box

Suggested Antigen Peptide Sequences for ZNF37A Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein KOX21 (ZN37A_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF37A: view

Function for ZNF37A Gene

Molecular function for ZNF37A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
UniProtKB/Swiss-Prot Induction:
Down-regulated in cells with DM1 (Myotonic dystrophy type 1) mutation, via a mechanism that involves abnormal control of its mRNA stability by CUGBP1.
GENATLAS Biochemistry:
zinc finger protein 37a (KOX21) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF37A Gene

Gene Ontology (GO) - Molecular Function for ZNF37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity NAS 8464732
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF37A: view
genes like me logo Genes that share phenotypes with ZNF37A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF37A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF37A Gene

Localization for ZNF37A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF37A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF37A gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8464732
genes like me logo Genes that share ontologies with ZNF37A: view

Pathways & Interactions for ZNF37A Gene

genes like me logo Genes that share pathways with ZNF37A: view

Pathways by source for ZNF37A Gene

2 Reactome pathways for ZNF37A Gene
1 KEGG pathway for ZNF37A Gene

Interacting Proteins for ZNF37A Gene

Gene Ontology (GO) - Biological Process for ZNF37A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated NAS 8464732
genes like me logo Genes that share ontologies with ZNF37A: view

No data available for SIGNOR curated interactions for ZNF37A Gene

Drugs & Compounds for ZNF37A Gene

No Compound Related Data Available

Transcripts for ZNF37A Gene

mRNA/cDNA for ZNF37A Gene

9 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF37A

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF37A Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: -
SP5: - - -
SP6: - - -
SP7: - - -
SP8: - -
SP10: -

Relevant External Links for ZNF37A Gene

GeneLoc Exon Structure for

Expression for ZNF37A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF37A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF37A

SOURCE GeneReport for Unigene cluster for ZNF37A Gene:


Evidence on tissue expression from TISSUES for ZNF37A Gene

  • Lung(4.2)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with ZNF37A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF37A Gene

Orthologs for ZNF37A Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF37A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF37A 30 31
  • 99.47 (n)
(Canis familiaris)
Mammalia ZNF37A 31
  • 82 (a)
(Bos Taurus)
Mammalia ZNF37A 31
  • 51 (a)
Species where no ortholog for ZNF37A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF37A Gene

Gene Tree for ZNF37A (if available)
Gene Tree for ZNF37A (if available)
Evolutionary constrained regions (ECRs) for ZNF37A: view image

Paralogs for ZNF37A Gene

Paralogs for ZNF37A Gene

(440) SIMAP similar genes for ZNF37A Gene using alignment to 1 proteins:

  • ZN37A_HUMAN Pseudogenes for ZNF37A Gene

genes like me logo Genes that share paralogs with ZNF37A: view

Variants for ZNF37A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF37A Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs2021319 - p.Asp105Asn

Additional dbSNP identifiers (rs#s) for ZNF37A Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF37A Gene

Variant ID Type Subtype PubMed ID
esv3576438 CNV gain 25503493
esv3578778 CNV loss 25503493
esv3622976 CNV loss 21293372
esv997851 CNV insertion 20482838
nsv1040704 CNV gain 25217958
nsv550419 CNV gain 21841781
nsv6465 CNV deletion 18451855

Variation tolerance for ZNF37A Gene

Residual Variation Intolerance Score: 19.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.63; 56.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF37A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF37A Gene

Disorders for ZNF37A Gene

Additional Disease Information for ZNF37A

No disorders were found for ZNF37A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF37A Gene

Publications for ZNF37A Gene

  1. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. (PMID: 8464732) Tunnacliffe A … Ponder BA (Nucleic acids research 1993) 2 3 4 23
  2. A defective Krab-domain zinc-finger transcription factor contributes to altered myogenesis in myotonic dystrophy type 1. (PMID: 23922231) Gauthier M … Martinat C (Human molecular genetics 2013) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for ZNF37A Gene

  • Signalway Proteins for ZNF37A

Sources for ZNF37A Gene