Aliases for ZNF366 Gene

Aliases for ZNF366 Gene

  • Zinc Finger Protein 366 2 3 4 5
  • Dendritic Cell-Specific Transcript Protein 3 4
  • DC-SCRIPT 3 4
  • DCSCRIPT 3

External Ids for ZNF366 Gene

Previous GeneCards Identifiers for ZNF366 Gene

  • GC05M070544
  • GC05M071972
  • GC05M071777
  • GC05M071823
  • GC05M071822
  • GC05M071774
  • GC05M066944

Summaries for ZNF366 Gene

GeneCards Summary for ZNF366 Gene

ZNF366 (Zinc Finger Protein 366) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity and estrogen receptor binding. An important paralog of this gene is ZNF710.

UniProtKB/Swiss-Prot Summary for ZNF366 Gene

  • Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.

Gene Wiki entry for ZNF366 Gene

Additional gene information for ZNF366 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF366 Gene

Genomics for ZNF366 Gene

GeneHancer (GH) Regulatory Elements for ZNF366 Gene

Promoters and enhancers for ZNF366 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF366 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF366

Top Transcription factor binding sites by QIAGEN in the ZNF366 gene promoter:
  • C/EBPalpha
  • CP2
  • FOXD3
  • FOXJ2 (long isoform)
  • MZF-1
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4

Genomic Locations for ZNF366 Gene

Genomic Locations for ZNF366 Gene
chr5:72,439,899-72,507,422
(GRCh38/hg38)
Size:
67,524 bases
Orientation:
Minus strand
chr5:71,738,479-71,803,554
(GRCh37/hg19)
Size:
65,076 bases
Orientation:
Minus strand

Genomic View for ZNF366 Gene

Genes around ZNF366 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF366 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF366 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF366 Gene

Proteins for ZNF366 Gene

  • Protein details for ZNF366 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N895-ZN366_HUMAN
    Recommended name:
    Zinc finger protein 366
    Protein Accession:
    Q8N895
    Secondary Accessions:
    • Q5HYI9
    • Q7RTV4

    Protein attributes for ZNF366 Gene

    Size:
    744 amino acids
    Molecular mass:
    85107 Da
    Quaternary structure:
    • Interacts with ESR1 and NRIP1 (PubMed:17085477). Interacts (via PXDLS motif) with CTBP1 (PubMed:16393996, PubMed:17085477).

neXtProt entry for ZNF366 Gene

Post-translational modifications for ZNF366 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF366 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF366 Gene

Domains & Families for ZNF366 Gene

Gene Families for ZNF366 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF366 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF366 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 366 (Q0VAH5_HUMAN)
  • Zinc finger protein 366 (ZN366_HUMAN)
genes like me logo Genes that share domains with ZNF366: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for ZNF366 Gene

Function for ZNF366 Gene

Molecular function for ZNF366 Gene

UniProtKB/Swiss-Prot Function:
Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.

Phenotypes From GWAS Catalog for ZNF366 Gene

Gene Ontology (GO) - Molecular Function for ZNF366 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity IDA 17085477
GO:0005515 protein binding IPI 17085477
GO:0030331 estrogen receptor binding IDA,IBA 17085477
genes like me logo Genes that share ontologies with ZNF366: view
genes like me logo Genes that share phenotypes with ZNF366: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF366

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF366 Gene

Localization for ZNF366 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF366 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF366 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ZNF366 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 17085477
genes like me logo Genes that share ontologies with ZNF366: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF366 Gene

Pathways & Interactions for ZNF366 Gene

PathCards logo

SuperPathways for ZNF366 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF366 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 17085477
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IBA,IDA 17085477
GO:0043627 response to estrogen IDA,IBA 17085477
genes like me logo Genes that share ontologies with ZNF366: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF366 Gene

Drugs & Compounds for ZNF366 Gene

No Compound Related Data Available

Transcripts for ZNF366 Gene

mRNA/cDNA for ZNF366 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF366

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF366 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - -
SP2:

Relevant External Links for ZNF366 Gene

GeneLoc Exon Structure for
ZNF366

Expression for ZNF366 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF366 Gene

Protein differential expression in normal tissues from HIPED for ZNF366 Gene

This gene is overexpressed in Heart (46.4) and Tlymphocyte (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF366 Gene



Protein tissue co-expression partners for ZNF366 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF366

SOURCE GeneReport for Unigene cluster for ZNF366 Gene:

Hs.370303

mRNA Expression by UniProt/SwissProt for ZNF366 Gene:

Q8N895-ZN366_HUMAN
Tissue specificity: Expressed in immature and mature dendritic cells (DCs). Not detected in other blood cell types.

Evidence on tissue expression from TISSUES for ZNF366 Gene

  • Spleen(4.3)
  • Heart(4)
genes like me logo Genes that share expression patterns with ZNF366: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF366 Gene

Orthologs for ZNF366 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF366 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF366 31 30
  • 99.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF366 31 30
  • 87.3 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp366 17 31 30
  • 85.25 (n)
rat
(Rattus norvegicus)
Mammalia Zfp366 30
  • 84.95 (n)
dog
(Canis familiaris)
Mammalia ZNF366 31 30
  • 79.15 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZNF366 31
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF366 31
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF366 31 30
  • 70.39 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF366 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf366 30
  • 66 (n)
zebrafish
(Danio rerio)
Actinopterygii znf366 31 30
  • 71.93 (n)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PZF1 31
  • 27 (a)
OneToMany
Species where no ortholog for ZNF366 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF366 Gene

ENSEMBL:
Gene Tree for ZNF366 (if available)
TreeFam:
Gene Tree for ZNF366 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF366: view image

Paralogs for ZNF366 Gene

Paralogs for ZNF366 Gene

genes like me logo Genes that share paralogs with ZNF366: view

Variants for ZNF366 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF366 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs13188519 - p.Ala739Gly

Additional dbSNP identifiers (rs#s) for ZNF366 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF366 Gene

Variant ID Type Subtype PubMed ID
esv2730293 CNV deletion 23290073
esv3324960 CNV insertion 20981092
esv3425812 CNV insertion 20981092
nsv516808 CNV loss 19592680
nsv819823 CNV gain 19587683
nsv830342 CNV gain 17160897

Variation tolerance for ZNF366 Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.43; 77.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF366 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF366

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF366 Gene

Disorders for ZNF366 Gene

Additional Disease Information for ZNF366

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF366 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF366 Gene

Publications for ZNF366 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study. (PMID: 19525478) Mälarstig A … Genetic Analysis of Idiopathic Thrombophilia (GAIT) and Precocious Coronary Artery Disease (PROCARDIS) consortia (Blood 2009) 3 41 54
  3. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 3 41 54
  4. ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases. (PMID: 17085477) Lopez-Garcia J … Ali S (Nucleic acids research 2006) 3 4 54
  5. Identification and characterization of DC-SCRIPT, a novel dendritic cell-expressed member of the zinc finger family of transcriptional regulators. (PMID: 16393996) Triantis V … Adema GJ (Journal of immunology (Baltimore, Md. : 1950) 2006) 3 4 54

Products for ZNF366 Gene

Sources for ZNF366 Gene