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Aliases for ZNF366 Gene

Aliases for ZNF366 Gene

  • Zinc Finger Protein 366 2 3 3 5
  • Dendritic Cell-Specific Transcript Protein 3 4
  • DC-SCRIPT 3 4

External Ids for ZNF366 Gene

Previous GeneCards Identifiers for ZNF366 Gene

  • GC05M070544
  • GC05M071972
  • GC05M071777
  • GC05M071823
  • GC05M071822
  • GC05M071774
  • GC05M066944

Summaries for ZNF366 Gene

GeneCards Summary for ZNF366 Gene

ZNF366 (Zinc Finger Protein 366) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity and estrogen receptor binding. An important paralog of this gene is ZNF710.

UniProtKB/Swiss-Prot for ZNF366 Gene

  • Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.

Gene Wiki entry for ZNF366 Gene

Additional gene information for ZNF366 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF366 Gene

Genomics for ZNF366 Gene

GeneHancer (GH) Regulatory Elements for ZNF366 Gene

Promoters and enhancers for ZNF366 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J072507 Promoter/Enhancer 1.7 EPDnew FANTOM5 ENCODE dbSUPER 653.9 -0.4 -378 0.9 PKNOX1 BATF IRF4 GATA3 ZNF766 POLR2A NFATC1 EED ATF7 ETV6 ZNF366 MRPS27 PTCD2 RN7SL153P FCHO2 LOC102503427
GH05J072505 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 650.7 +1.5 1526 1.2 IRF2 STAT1 ZNF740 L3MBTL2 CEBPB CEBPG ATF2 ZNF148 IRF9 ATF4 ZNF366 GC05P072450
GH05J072509 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.7 +0.3 297 0.1 ZNF366 GC05P072450
GH05J072510 Promoter/Enhancer 0.7 Ensembl dbSUPER 650.7 +0.6 626 0.2 ZNF366 GC05P072450
GH05J072463 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 14.1 +39.6 39649 10.2 ATF1 SMAD1 IRF4 ZNF766 ZNF207 FOS ATF7 RUNX3 RXRA JUNB ZNF366 ENSG00000272081 MAP1B FCHO2 GC05P072450
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF366 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF366 gene promoter:
  • C/EBPalpha
  • MZF-1
  • FOXD3
  • NF-AT
  • NF-AT1
  • NF-AT2
  • NF-AT3
  • NF-AT4
  • FOXJ2 (long isoform)
  • CP2

Genomic Locations for ZNF366 Gene

Genomic Locations for ZNF366 Gene
67,829 bases
Minus strand
65,076 bases
Minus strand

Genomic View for ZNF366 Gene

Genes around ZNF366 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF366 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF366 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF366 Gene

Proteins for ZNF366 Gene

  • Protein details for ZNF366 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 366
    Protein Accession:
    Secondary Accessions:
    • Q5HYI9
    • Q7RTV4

    Protein attributes for ZNF366 Gene

    744 amino acids
    Molecular mass:
    85107 Da
    Quaternary structure:
    • Interacts with ESR1 and NRIP1 (PubMed:17085477). Interacts (via PXDLS motif) with CTBP1 (PubMed:16393996, PubMed:17085477).

neXtProt entry for ZNF366 Gene

Post-translational modifications for ZNF366 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF366 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF366 Gene

Domains & Families for ZNF366 Gene

Gene Families for ZNF366 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF366 Gene


Suggested Antigen Peptide Sequences for ZNF366 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ZNF366: view

No data available for UniProtKB/Swiss-Prot for ZNF366 Gene

Function for ZNF366 Gene

Molecular function for ZNF366 Gene

UniProtKB/Swiss-Prot Function:
Has transcriptional repression activity. Acts as corepressor of ESR1; the function seems to involve CTBP1 and histone deacetylases.

Phenotypes From GWAS Catalog for ZNF366 Gene

Gene Ontology (GO) - Molecular Function for ZNF366 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003714 transcription corepressor activity IDA 17085477
GO:0005515 protein binding IPI 17085477
genes like me logo Genes that share ontologies with ZNF366: view
genes like me logo Genes that share phenotypes with ZNF366: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF366

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF366 Gene

Localization for ZNF366 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF366 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF366 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for ZNF366 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 17085477
genes like me logo Genes that share ontologies with ZNF366: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF366 Gene

Pathways & Interactions for ZNF366 Gene

SuperPathways for ZNF366 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF366 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 17085477
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway IDA 17085477
GO:0043627 response to estrogen IDA 17085477
genes like me logo Genes that share ontologies with ZNF366: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF366 Gene

Drugs & Compounds for ZNF366 Gene

No Compound Related Data Available

Transcripts for ZNF366 Gene

mRNA/cDNA for ZNF366 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(33) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF366 Gene

Zinc finger protein 366:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF366

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF366 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - -

Relevant External Links for ZNF366 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF366 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF366 Gene

Protein differential expression in normal tissues from HIPED for ZNF366 Gene

This gene is overexpressed in Heart (46.4) and Tlymphocyte (16.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF366 Gene

Protein tissue co-expression partners for ZNF366 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF366 Gene:


SOURCE GeneReport for Unigene cluster for ZNF366 Gene:


mRNA Expression by UniProt/SwissProt for ZNF366 Gene:

Tissue specificity: Expressed in immature and mature dendritic cells (DCs). Not detected in other blood cell types.

Evidence on tissue expression from TISSUES for ZNF366 Gene

  • Spleen(4.3)
  • Heart(4)
genes like me logo Genes that share expression patterns with ZNF366: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF366 Gene

Orthologs for ZNF366 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ZNF366 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF366 34 33
  • 99.37 (n)
(Bos Taurus)
Mammalia ZNF366 34 33
  • 87.3 (n)
(Mus musculus)
Mammalia Zfp366 16 34 33
  • 85.25 (n)
(Rattus norvegicus)
Mammalia Zfp366 33
  • 84.95 (n)
(Canis familiaris)
Mammalia ZNF366 34 33
  • 79.15 (n)
(Monodelphis domestica)
Mammalia ZNF366 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia ZNF366 34
  • 72 (a)
(Gallus gallus)
Aves ZNF366 34 33
  • 70.39 (n)
(Anolis carolinensis)
Reptilia ZNF366 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf366 33
  • 66 (n)
(Danio rerio)
Actinopterygii znf366 34 33
  • 71.93 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PZF1 34
  • 27 (a)
Species where no ortholog for ZNF366 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF366 Gene

Gene Tree for ZNF366 (if available)
Gene Tree for ZNF366 (if available)
Evolutionary constrained regions (ECRs) for ZNF366: view image

Paralogs for ZNF366 Gene

Paralogs for ZNF366 Gene

genes like me logo Genes that share paralogs with ZNF366: view

Variants for ZNF366 Gene

Sequence variations from dbSNP and Humsavar for ZNF366 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000032618 -- 72,502,034(-) A/C intron_variant
rs1000051475 -- 72,459,258(-) C/G intron_variant
rs1000084919 -- 72,466,143(-) T/A intron_variant
rs1000118851 -- 72,503,384(-) T/C intron_variant
rs1000173744 -- 72,462,946(-) T/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF366 Gene

Variant ID Type Subtype PubMed ID
esv2730293 CNV deletion 23290073
esv3324960 CNV insertion 20981092
esv3425812 CNV insertion 20981092
nsv516808 CNV loss 19592680
nsv819823 CNV gain 19587683
nsv830342 CNV gain 17160897

Variation tolerance for ZNF366 Gene

Residual Variation Intolerance Score: 32.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.43; 77.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF366 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF366 Gene

Disorders for ZNF366 Gene

Additional Disease Information for ZNF366

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF366 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF366 Gene

Publications for ZNF366 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study. (PMID: 19525478) Mälarstig A … Genetic Analysis of Idiopathic Thrombophilia (GAIT) and Precocious Coronary Artery Disease (PROCARDIS) consortia (Blood 2009) 3 44 58
  3. Genome-wide association with bone mass and geometry in the Framingham Heart Study. (PMID: 17903296) Kiel DP … Karasik D (BMC medical genetics 2007) 3 44 58
  4. Identification and characterization of DC-SCRIPT, a novel dendritic cell-expressed member of the zinc finger family of transcriptional regulators. (PMID: 16393996) Triantis V … Adema GJ (Journal of immunology (Baltimore, Md. : 1950) 2006) 3 4 58
  5. ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases. (PMID: 17085477) Lopez-Garcia J … Ali S (Nucleic acids research 2006) 3 4 58

Products for ZNF366 Gene

Sources for ZNF366 Gene

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