Aliases for ZNF362 Gene

Aliases for ZNF362 Gene

  • Zinc Finger Protein 362 2 3 4 5
  • Lin-29 2 3
  • RN 2 3
  • Rotund Homolog (Drosophila) 2
  • Rotund Homolog 3
  • FLJ25476 2
  • ZNF362 5

External Ids for ZNF362 Gene

Previous GeneCards Identifiers for ZNF362 Gene

  • GC00U991155
  • GC01P033494
  • GC01P033722
  • GC01P031852

Summaries for ZNF362 Gene

GeneCards Summary for ZNF362 Gene

ZNF362 (Zinc Finger Protein 362) is a Protein Coding gene. Diseases associated with ZNF362 include Hemophagocytic Lymphohistiocytosis, Familial, 2 and Hemophagocytic Lymphohistiocytosis, Familial, 1. An important paralog of this gene is ZNF384.

UniProtKB/Swiss-Prot Summary for ZNF362 Gene

Additional gene information for ZNF362 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF362 Gene

Genomics for ZNF362 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF362 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J033254 Promoter/Enhancer 2.3 VISTA EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.9 883 4.4 HNRNPL GATAD2A PRDM10 TFE3 SOX13 KDM1A ZNF692 NFRKB RCOR2 POLR2A ZNF362 piR-35146 A3GALT2 ENSG00000270115
GH01J033238 Promoter 0.7 EPDnew 600.4 -17.7 -17739 0.1 CBX3 RAD51 USF1 NFYB FOS USF2 NFYC L3MBTL2 ZNF362 TRIM62 piR-37895-001
GH01J032262 Enhancer 1.2 FANTOM5 ENCODE dbSUPER 29.9 -991.7 -991674 3.3 ZNF629 JUND CEBPA SCRT2 ZNF140 ZXDB ZNF580 ZNF266 MEF2D MYNN TXLNA KHDRBS1 RBBP4 SNRNP40 ZBTB8A TMEM39B ZNF362 ENSG00000224066 DCDC2B TSSK3
GH01J033470 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 +215.5 215544 3.5 SP1 CREB1 GATAD2A CTCF PRDM10 REST SIX5 LEF1 IKZF1 POLR2A ZSCAN20 ZBTB8A AK2 CSMD2 ZNF362 RBBP4 PHC2 HPCA TLR12P
GH01J032271 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 11.2 -982.8 -982803 5 PRDM10 ZNF692 PRDM1 MTA2 ZNF776 ZSCAN4 MTA1 PATZ1 ZNF239 SCRT2 Hsa-Mir-574_5p-004 LCK RBBP4 TXLNA IQCC ZBTB8A KHDRBS1 SNRNP40 S100PBP ZBTB8B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF362 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF362

Top Transcription factor binding sites by QIAGEN in the ZNF362 gene promoter:
  • AhR
  • AP-4
  • AREB6
  • Arnt
  • C/EBPalpha
  • FOXO1
  • FOXO1a
  • MyoD
  • MZF-1
  • POU3F1

Genomic Locations for ZNF362 Gene

Genomic Locations for ZNF362 Gene
chr1:33,256,307-33,300,719
(GRCh38/hg38)
Size:
44,413 bases
Orientation:
Plus strand
chr1:33,722,146-33,766,320
(GRCh37/hg19)
Size:
44,175 bases
Orientation:
Plus strand

Genomic View for ZNF362 Gene

Genes around ZNF362 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF362 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF362 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF362 Gene

Proteins for ZNF362 Gene

  • Protein details for ZNF362 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T0B9-ZN362_HUMAN
    Recommended name:
    Zinc finger protein 362
    Protein Accession:
    Q5T0B9
    Secondary Accessions:
    • Q8WYU4

    Protein attributes for ZNF362 Gene

    Size:
    420 amino acids
    Molecular mass:
    45814 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF362 Gene

Post-translational modifications for ZNF362 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF362 Gene

No data available for DME Specific Peptides for ZNF362 Gene

Domains & Families for ZNF362 Gene

Gene Families for ZNF362 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF362 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF362 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 362 (ZN362_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q5T0B9

UniProtKB/Swiss-Prot:

ZN362_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF362: view

Function for ZNF362 Gene

Molecular function for ZNF362 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF362 Gene

Gene Ontology (GO) - Molecular Function for ZNF362 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF362: view
genes like me logo Genes that share phenotypes with ZNF362: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF362

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF362 Gene

Localization for ZNF362 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF362 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF362 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF362 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF362: view

Pathways & Interactions for ZNF362 Gene

PathCards logo

SuperPathways for ZNF362 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF362 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ZNF362 Gene

Drugs & Compounds for ZNF362 Gene

No Compound Related Data Available

Transcripts for ZNF362 Gene

mRNA/cDNA for ZNF362 Gene

2 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF362

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF362 Gene

No ASD Table

Relevant External Links for ZNF362 Gene

GeneLoc Exon Structure for
ZNF362

Expression for ZNF362 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF362 Gene

Protein differential expression in normal tissues from HIPED for ZNF362 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (25.5), Tlymphocyte (11.7), Placenta (8.5), Fetal testis (8.5), and Fetal Brain (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF362 Gene



Protein tissue co-expression partners for ZNF362 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF362

SOURCE GeneReport for Unigene cluster for ZNF362 Gene:

Hs.743358

Evidence on tissue expression from TISSUES for ZNF362 Gene

  • Nervous system(4.5)
  • Liver(4.2)
  • Muscle(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with ZNF362: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF362 Gene

Orthologs for ZNF362 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF362 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF362 30 31
  • 99.84 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF362 30 31
  • 95.19 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF362 30 31
  • 94.63 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp362 30
  • 92.82 (n)
Mouse
(Mus musculus)
Mammalia Zfp362 30 17 31
  • 91.63 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia ZNF362 31
  • 76 (a)
OneToOne
Chicken
(Gallus gallus)
Aves ZNF362 30 31
  • 86.57 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia ZNF362 31
  • 93 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia znf362 30
  • 80.81 (n)
Zebrafish
(Danio rerio)
Actinopterygii znf362b 30 31
  • 73.32 (n)
OneToMany
znf362a 31
  • 70 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta sqz 31
  • 21 (a)
ManyToMany
rn 31
  • 16 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea lin-29 31
  • 23 (a)
OneToMany
Species where no ortholog for ZNF362 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for ZNF362 Gene

ENSEMBL:
Gene Tree for ZNF362 (if available)
TreeFam:
Gene Tree for ZNF362 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF362: view image

Paralogs for ZNF362 Gene

genes like me logo Genes that share paralogs with ZNF362: view

Variants for ZNF362 Gene

Additional dbSNP identifiers (rs#s) for ZNF362 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF362 Gene

Variant ID Type Subtype PubMed ID
nsv1112530 CNV deletion 24896259
nsv522364 CNV loss 19592680
nsv524709 CNV loss 19592680
nsv545963 CNV loss 21841781

Variation tolerance for ZNF362 Gene

Residual Variation Intolerance Score: 25.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF362 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF362

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF362 Gene

Disorders for ZNF362 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF362 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF362: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF362 Gene

Publications for ZNF362 Gene

  1. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. (PMID: 31091453) Shami Shah A … Baskin JM (Cell reports 2019) 3
  2. USP7 Regulates Cytokinesis through FBXO38 and KIF20B. (PMID: 30804394) Georges A … Frappier L (Scientific reports 2019) 3
  3. Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells. (PMID: 30585729) Abbasi S … Schild-Poulter C (Journal of proteome research 2019) 3
  4. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. (PMID: 29180619) Kumar R … Vertegaal ACO (Nature communications 2017) 3
  5. Comprehensive Proteomic Analysis of PGC7-Interacting Proteins. (PMID: 28712289) Liu H … Guo Z (Journal of proteome research 2017) 3

Products for ZNF362 Gene

Sources for ZNF362 Gene