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Aliases for ZNF358 Gene

Aliases for ZNF358 Gene

  • Zinc Finger Protein 358 2 3 5
  • ZFEND 3

External Ids for ZNF358 Gene

Previous GeneCards Identifiers for ZNF358 Gene

  • GC19P007538
  • GC19P007685
  • GC19P007452
  • GC19P007490
  • GC19P007487
  • GC19P007255
  • GC19P007580

Summaries for ZNF358 Gene

GeneCards Summary for ZNF358 Gene

ZNF358 (Zinc Finger Protein 358) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF768.

UniProtKB/Swiss-Prot for ZNF358 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF358 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF358 Gene

Genomics for ZNF358 Gene

GeneHancer (GH) Regulatory Elements for ZNF358 Gene

Promoters and enhancers for ZNF358 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I007514 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +0.6 623 2.8 HDGF ARNT ARID4B YBX1 DMAP1 ZNF48 YY1 ZNF121 ARID2 ZNF143 ZNF358 HNRNPM XAB2 ZNF557 ELAVL1 TRIP10 ZNF414 MAP2K7 ENSG00000269680 SH2D3A
GH19I007512 Enhancer 0.6 ENCODE 0.8 -2.4 -2442 0.9 HDAC1 ZBTB6 ZNF449 CEBPB ASH1L ZNF398 CC2D1A FOXM1 GATA3 NFYB PNPLA6 ARHGEF18 PEX11G ELAVL1 ZNF358 ENSG00000267952 GC19M007510 TEX45
GH19I007507 Enhancer 0.9 Ensembl ENCODE 0.4 -7.2 -7181 0.6 HDGF KLF1 JUN MAX FOSL1 GLIS2 POLR2A PATZ1 FOSL2 FOS ENSG00000267952 PEX11G ZNF358 TEX45
GH19I007520 Enhancer 0.5 dbSUPER 0.4 +5.6 5646 1 ZNF664 ZNF3 RXRA MAX HNF4A RAD21 NR2F2 MCOLN1 GC19M007510 LOC105372261 ZNF358
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF358 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF358 gene promoter:

Genomic Locations for ZNF358 Gene

Genomic Locations for ZNF358 Gene
chr19:7,515,282-7,521,026
(GRCh38/hg38)
Size:
5,745 bases
Orientation:
Plus strand
chr19:7,580,178-7,585,912
(GRCh37/hg19)

Genomic View for ZNF358 Gene

Genes around ZNF358 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF358 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF358 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF358 Gene

Proteins for ZNF358 Gene

  • Protein details for ZNF358 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NW07-ZN358_HUMAN
    Recommended name:
    Zinc finger protein 358
    Protein Accession:
    Q9NW07
    Secondary Accessions:
    • Q9BTM7

    Protein attributes for ZNF358 Gene

    Size:
    568 amino acids
    Molecular mass:
    59287 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH14002.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA91582.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ZNF358 Gene

Post-translational modifications for ZNF358 Gene

  • Ubiquitination at isoforms=280
  • Modification sites at PhosphoSitePlus

Other Protein References for ZNF358 Gene

No data available for DME Specific Peptides for ZNF358 Gene

Domains & Families for ZNF358 Gene

Gene Families for ZNF358 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF358 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF358 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NW07

UniProtKB/Swiss-Prot:

ZN358_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF358: view

Function for ZNF358 Gene

Molecular function for ZNF358 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Gene Ontology (GO) - Molecular Function for ZNF358 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF358: view
genes like me logo Genes that share phenotypes with ZNF358: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF358 Gene

Localization for ZNF358 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF358 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF358 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF358 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF358: view

Pathways & Interactions for ZNF358 Gene

SuperPathways for ZNF358 Gene

No Data Available

Interacting Proteins for ZNF358 Gene

Selected Interacting proteins: Q9NW07-ZN358_HUMAN for ZNF358 Gene via IID

Gene Ontology (GO) - Biological Process for ZNF358 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0019827 stem cell population maintenance ISS --
GO:0021915 neural tube development ISS --
GO:0035115 embryonic forelimb morphogenesis ISS --
genes like me logo Genes that share ontologies with ZNF358: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF358 Gene

Drugs & Compounds for ZNF358 Gene

No Compound Related Data Available

Transcripts for ZNF358 Gene

mRNA/cDNA for ZNF358 Gene

Unigene Clusters for ZNF358 Gene

Zinc finger protein 358:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF358 Gene

No ASD Table

Relevant External Links for ZNF358 Gene

GeneLoc Exon Structure for
ZNF358
ECgene alternative splicing isoforms for
ZNF358

Expression for ZNF358 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF358 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF358 Gene

This gene is overexpressed in Colon - Sigmoid (x7.6), Ovary (x7.2), Bladder (x6.7), Esophagus - Muscularis (x5.1), Esophagus - Gastroesophageal Junction (x4.2), and Colon - Transverse (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF358 Gene

This gene is overexpressed in Fetal Brain (24.7), Ovary (23.6), and Fetal ovary (17.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF358 Gene



Protein tissue co-expression partners for ZNF358 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF358 Gene:

ZNF358

SOURCE GeneReport for Unigene cluster for ZNF358 Gene:

Hs.133475

Evidence on tissue expression from TISSUES for ZNF358 Gene

  • Liver(4.3)
  • Eye(4.1)
  • Muscle(2.7)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with ZNF358: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF358 Gene

Orthologs for ZNF358 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF358 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF358 34 33
  • 99.34 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF358 34
  • 88 (a)
OneToOne
C20H19orf45 33
  • 87.67 (n)
cow
(Bos Taurus)
Mammalia ZNF358 33 34
  • 84.78 (n)
rat
(Rattus norvegicus)
Mammalia Zfp358 33
  • 79.66 (n)
mouse
(Mus musculus)
Mammalia Zfp358 34 16 33
  • 79.62 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta gl 35
  • 51 (a)
jim 35
  • 45 (a)
Species where no ortholog for ZNF358 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF358 Gene

ENSEMBL:
Gene Tree for ZNF358 (if available)
TreeFam:
Gene Tree for ZNF358 (if available)

Paralogs for ZNF358 Gene

Paralogs for ZNF358 Gene

(448) SIMAP similar genes for ZNF358 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF358: view

Variants for ZNF358 Gene

Sequence variations from dbSNP and Humsavar for ZNF358 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000534662 -- 7,517,164(+) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001134893 -- 7,515,522(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1001631576 -- 7,515,857(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002188651 -- 7,514,555(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1002665595 -- 7,516,241(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF358 Gene

Variant ID Type Subtype PubMed ID
esv2751809 CNV gain 17911159
nsv1060887 CNV gain 25217958
nsv828416 CNV loss 20364138
nsv833730 CNV loss 17160897

Variation tolerance for ZNF358 Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.69; 73.00% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF358 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF358

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF358 Gene

Disorders for ZNF358 Gene

Additional Disease Information for ZNF358

No disorders were found for ZNF358 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF358 Gene

Publications for ZNF358 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58

Products for ZNF358 Gene

Sources for ZNF358 Gene

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