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Aliases for ZNF354C Gene

Aliases for ZNF354C Gene

  • Zinc Finger Protein 354C 2 3 3 5
  • Kidney, Ischemia, And Developmentally-Regulated Protein 3 3 4
  • KID3 3 4
  • KRAB-Zinc Finger Protein Synten 3
  • HKID3 4

External Ids for ZNF354C Gene

Previous GeneCards Identifiers for ZNF354C Gene

  • GC05P178579
  • GC05P179396
  • GC05P178601
  • GC05P178420
  • GC05P178487
  • GC05P173215

Summaries for ZNF354C Gene

GeneCards Summary for ZNF354C Gene

ZNF354C (Zinc Finger Protein 354C) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity.

UniProtKB/Swiss-Prot for ZNF354C Gene

  • May function as a transcription repressor. Binds to 5-CCACA-3 core sequence. Suppresses osteogenic effects of RUNX2. May be involved in osteoblastic differentiation (By similarity). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).

Additional gene information for ZNF354C Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF354C Gene

Genomics for ZNF354C Gene

GeneHancer (GH) Regulatory Elements for ZNF354C Gene

Promoters and enhancers for ZNF354C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J179023 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 672.1 -36.6 -36614 1.6 ATF1 SIN3A ZNF2 YY1 ETS1 ZNF213 ELK1 ZNF143 ATF7 SP3 ZNF354C ZNF879 ZNF354B MRNIP HNRNPH1 MAML1 PIR62665
GH05J179059 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 657 +0.2 166 1.7 SIN3A ZNF2 RAD21 YY1 ETS1 ZNF335 ELK1 ZNF143 RCOR1 EGR2 ZNF354C ENSG00000253144
GH05J179619 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 43.6 +561.9 561858 6.1 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 HNRNPH1 MAML1 ZNF879 MRNIP RUFY1 ZNF354C ZFP2 GRM6 LOC100996419 ENSG00000254035
GH05J178203 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 46 -850.7 -850671 12.3 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 HNRNPAB ENSG00000247679 FAM193B ZNF879 LOC202181 ZNF354C CLK4 RMND5B ENSG00000254035 MXD3
GH05J179549 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 41 +490.2 490247 3.1 ARNT SIN3A ZNF2 YY1 POLR2B ZNF766 MXD4 REST ZNF592 KAT8 RUFY1 LOC105377762 ZNF879 ZNF354C MRNIP MAML1 HNRNPH1 CNOT6 CLK4 LOC105377763
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF354C on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF354C Gene

Genomic Locations for ZNF354C Gene
chr5:179,060,415-179,086,298
(GRCh38/hg38)
Size:
25,884 bases
Orientation:
Plus strand
chr5:178,487,416-178,510,538
(GRCh37/hg19)
Size:
23,123 bases
Orientation:
Plus strand

Genomic View for ZNF354C Gene

Genes around ZNF354C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF354C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF354C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF354C Gene

Proteins for ZNF354C Gene

  • Protein details for ZNF354C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Y25-Z354C_HUMAN
    Recommended name:
    Zinc finger protein 354C
    Protein Accession:
    Q86Y25
    Secondary Accessions:
    • Q6P4P9
    • Q8NFX1

    Protein attributes for ZNF354C Gene

    Size:
    554 amino acids
    Molecular mass:
    64847 Da
    Quaternary structure:
    • Interacts with RUNX2. Binds consensus element OSE2 (By similarity).
    SequenceCaution:
    • Sequence=AAH63312.1; Type=Frameshift; Positions=473; Evidence={ECO:0000305};

neXtProt entry for ZNF354C Gene

Post-translational modifications for ZNF354C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF354C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF354C Gene

Domains & Families for ZNF354C Gene

Gene Families for ZNF354C Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF354C Gene

Suggested Antigen Peptide Sequences for ZNF354C Gene

Graphical View of Domain Structure for InterPro Entry

Q86Y25

UniProtKB/Swiss-Prot:

Z354C_HUMAN :
  • KRAB domain is not required for nuclear targeting or for DNA binding.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Domain:
  • KRAB domain is not required for nuclear targeting or for DNA binding.
  • Zinc finger region is involved in nuclear targeting and DNA-binding.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF354C: view

Function for ZNF354C Gene

Molecular function for ZNF354C Gene

UniProtKB/Swiss-Prot Function:
May function as a transcription repressor. Binds to 5-CCACA-3 core sequence. Suppresses osteogenic effects of RUNX2. May be involved in osteoblastic differentiation (By similarity). Plays a role in postnatal myogenesis, may be involved in the regulation of satellite cells self-renewal (By similarity).

Phenotypes From GWAS Catalog for ZNF354C Gene

Gene Ontology (GO) - Molecular Function for ZNF354C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF354C: view
genes like me logo Genes that share phenotypes with ZNF354C: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF354C Gene

Localization for ZNF354C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF354C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF354C gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF354C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA,IEA --
GO:0005829 cytosol IDA --
GO:0031965 nuclear membrane IDA --
genes like me logo Genes that share ontologies with ZNF354C: view

Pathways & Interactions for ZNF354C Gene

SuperPathways for ZNF354C Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF354C: view

Pathways by source for ZNF354C Gene

2 Reactome pathways for ZNF354C Gene

Interacting Proteins for ZNF354C Gene

Gene Ontology (GO) - Biological Process for ZNF354C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF354C: view

No data available for SIGNOR curated interactions for ZNF354C Gene

Drugs & Compounds for ZNF354C Gene

No Compound Related Data Available

Transcripts for ZNF354C Gene

mRNA/cDNA for ZNF354C Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(48) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF354C Gene

Zinc finger protein 354C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF354C Gene

No ASD Table

Relevant External Links for ZNF354C Gene

GeneLoc Exon Structure for
ZNF354C
ECgene alternative splicing isoforms for
ZNF354C

Expression for ZNF354C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF354C Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF354C Gene:

ZNF354C

SOURCE GeneReport for Unigene cluster for ZNF354C Gene:

Hs.272328

mRNA Expression by UniProt/SwissProt for ZNF354C Gene:

Q86Y25-Z354C_HUMAN
Tissue specificity: Expressed in kidney and skeletal muscle. Very low expression in brain and heart.

Evidence on tissue expression from TISSUES for ZNF354C Gene

  • Kidney(4.3)
genes like me logo Genes that share expression patterns with ZNF354C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF354C Gene

Orthologs for ZNF354C Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF354C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF354C 34 33
  • 99.34 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF354C 34 33
  • 87.65 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF354C 34 33
  • 85.26 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp354c 16 34 33
  • 77.96 (n)
rat
(Rattus norvegicus)
Mammalia Zfp354c 33
  • 76.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 44 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 31 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8388 35
  • 30 (a)
CG9609 35
  • 30 (a)
CG6654 34
  • 22 (a)
OneToMany
Species where no ortholog for ZNF354C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF354C Gene

ENSEMBL:
Gene Tree for ZNF354C (if available)
TreeFam:
Gene Tree for ZNF354C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF354C: view image

Paralogs for ZNF354C Gene

(463) SIMAP similar genes for ZNF354C Gene using alignment to 1 proteins:

  • Z354C_HUMAN
genes like me logo Genes that share paralogs with ZNF354C: view

No data available for Paralogs for ZNF354C Gene

Variants for ZNF354C Gene

Sequence variations from dbSNP and Humsavar for ZNF354C Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000084458 -- 179,074,952(+) A/C intron_variant
rs1000478750 -- 179,079,872(+) T/C coding_sequence_variant, synonymous_variant
rs1000553549 -- 179,069,640(+) T/C intron_variant
rs1000560800 -- 179,074,619(+) T/C intron_variant
rs1000818171 -- 179,079,476(+) A/G coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF354C Gene

Variant ID Type Subtype PubMed ID
nsv600491 CNV loss 21841781
nsv510009 OTHER sequence alteration 20534489
nsv1120062 OTHER inversion 24896259
nsv1033597 CNV gain 25217958
nsv1027487 CNV gain 25217958
nsv1023392 CNV loss 25217958
nsv1021642 CNV gain 25217958
dgv5846n100 CNV loss 25217958
dgv5845n100 CNV gain 25217958

Variation tolerance for ZNF354C Gene

Residual Variation Intolerance Score: 59.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF354C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF354C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF354C Gene

Disorders for ZNF354C Gene

Additional Disease Information for ZNF354C

No disorders were found for ZNF354C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF354C Gene

Publications for ZNF354C Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Cloning and characterization of a novel human zinc finger gene, hKid3, from a C2H2-ZNF enriched human embryonic cDNA library. (PMID: 15555547) Gao L … Li WX (Biochemical and biophysical research communications 2004) 3 4 58
  3. Characterisation, chromosomal localisation and expression of the mouse Kid3 gene. (PMID: 10786630) Watson RP … Boulter CA (Biochimica et biophysica acta 2000) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZNF354C Gene

Sources for ZNF354C Gene

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