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Aliases for ZNF354B Gene

Aliases for ZNF354B Gene

  • Zinc Finger Protein 354B 2 3 5
  • KID2 3

External Ids for ZNF354B Gene

Previous GeneCards Identifiers for ZNF354B Gene

  • GC00U991132
  • GC05P179195
  • GC05P178355
  • GC05P178400
  • GC05P178219
  • GC05P173013
  • GC05P178286

Summaries for ZNF354B Gene

GeneCards Summary for ZNF354B Gene

ZNF354B (Zinc Finger Protein 354B) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and chromatin binding. An important paralog of this gene is ZNF354A.

UniProtKB/Swiss-Prot for ZNF354B Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF354B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF354B Gene

Genomics for ZNF354B Gene

GeneHancer (GH) Regulatory Elements for ZNF354B Gene

Promoters and enhancers for ZNF354B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I178859 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 569.2 +0.4 418 2.1 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF207 ZNF143 SP3 ZNF354B PIR49665 LOC105377763 ZNF354C GC05P178886
GH05I179696 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 55.8 +839.0 838992 4.9 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC CANX GC05M179696 MAML1 HNRNPH1 ZNF354B RUFY1 MRNIP ZNF879 LOC101928445 ADAMTS2
GH05I178624 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 34.1 -233.9 -233921 3.8 HDGF ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF766 ZNF213 E2F8 CLK4 ZNF354B ZNF354C COL23A1 ZNF879 RUFY1 HNRNPAB GRM6 PHYKPL RN7SKP70
GH05I179677 Promoter/Enhancer 1.6 Ensembl ENCODE 27.9 +818.7 818653 2.3 HDGF PKNOX1 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 HMGB3P22 CANX MRNIP HNRNPH1 MAML1 ZNF354B ZNF879 CNOT6 RUFY1 TBC1D9B
GH05I178111 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.3 -739.8 -739836 16.8 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B IRF4 N4BP3 NSD1 ENSG00000247679 FAM193B ZNF354B CLK4 LOC202181 RMND5B HNRNPAB RPL21P60
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF354B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF354B gene promoter:

Genomic Locations for ZNF354B Gene

Genomic Locations for ZNF354B Gene
28,170 bases
Plus strand

Genomic View for ZNF354B Gene

Genes around ZNF354B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF354B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF354B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF354B Gene

Proteins for ZNF354B Gene

  • Protein details for ZNF354B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 354B
    Protein Accession:
    Secondary Accessions:
    • A8K0V2
    • Q5U5Z4

    Protein attributes for ZNF354B Gene

    612 amino acids
    Molecular mass:
    70529 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF354B Gene

Post-translational modifications for ZNF354B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF354B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF354B Gene

Domains & Families for ZNF354B Gene

Gene Families for ZNF354B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF354B Gene

Suggested Antigen Peptide Sequences for ZNF354B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF354B: view

Function for ZNF354B Gene

Molecular function for ZNF354B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF354B Gene

Gene Ontology (GO) - Molecular Function for ZNF354B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF354B: view
genes like me logo Genes that share phenotypes with ZNF354B: view

Animal Model Products

CRISPR Products

miRNA for ZNF354B Gene

miRTarBase miRNAs that target ZNF354B

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF354B Gene

Localization for ZNF354B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF354B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF354B gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF354B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF354B: view

Pathways & Interactions for ZNF354B Gene

SuperPathways for ZNF354B Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF354B: view

Pathways by source for ZNF354B Gene

2 Reactome pathways for ZNF354B Gene

Interacting Proteins for ZNF354B Gene

Gene Ontology (GO) - Biological Process for ZNF354B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF354B: view

No data available for SIGNOR curated interactions for ZNF354B Gene

Drugs & Compounds for ZNF354B Gene

No Compound Related Data Available

Transcripts for ZNF354B Gene

Unigene Clusters for ZNF354B Gene

Zinc finger protein 354B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF354B Gene

No ASD Table

Relevant External Links for ZNF354B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF354B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF354B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF354B Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ZNF354B Gene

Protein tissue co-expression partners for ZNF354B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF354B Gene:


SOURCE GeneReport for Unigene cluster for ZNF354B Gene:


Evidence on tissue expression from TISSUES for ZNF354B Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF354B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF354B Gene

Orthologs for ZNF354B Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF354B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF354B 33 34
  • 99.62 (n)
(Bos Taurus)
Mammalia LOC510078 33
  • 88.42 (n)
ZNF354B 34
  • 87 (a)
(Canis familiaris)
Mammalia ZNF354B 33 34
  • 87.54 (n)
(Rattus norvegicus)
Mammalia LOC102556119 33
  • 83.31 (n)
(Mus musculus)
Mammalia Zfp354b 33 16 34
  • 81.91 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 50 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aef1 35
  • 57 (a)
CG3407 35
  • 41 (a)
CG8484 35
  • 27 (a)
Species where no ortholog for ZNF354B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF354B Gene

Gene Tree for ZNF354B (if available)
Gene Tree for ZNF354B (if available)

Paralogs for ZNF354B Gene

Paralogs for ZNF354B Gene

(453) SIMAP similar genes for ZNF354B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ZNF354B: view

Variants for ZNF354B Gene

Sequence variations from dbSNP and Humsavar for ZNF354B Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000006789 -- 178,873,695(+) AAA/AAAA intron_variant
rs1000089818 -- 178,864,271(+) T/C intron_variant
rs1000134128 -- 178,860,811(+) C/G/T intron_variant
rs1000199107 -- 178,896,028(+) C/A genic_downstream_transcript_variant, intron_variant
rs1000232035 -- 178,899,642(+) C/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF354B Gene

Variant ID Type Subtype PubMed ID
dgv1681e212 CNV loss 25503493
esv3570589 CNV loss 25503493
esv3890769 CNV gain 25118596
nsv1120062 OTHER inversion 24896259
nsv462574 CNV loss 19166990
nsv600463 CNV loss 21841781
nsv823352 CNV gain 20364138
nsv964987 CNV duplication 23825009

Variation tolerance for ZNF354B Gene

Residual Variation Intolerance Score: 71.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.61; 30.97% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF354B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF354B Gene

Disorders for ZNF354B Gene

Additional Disease Information for ZNF354B

No disorders were found for ZNF354B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF354B Gene

Publications for ZNF354B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
  5. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3

Products for ZNF354B Gene

Sources for ZNF354B Gene

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