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Aliases for ZNF354A Gene

Aliases for ZNF354A Gene

  • Zinc Finger Protein 354A 2 3 3 5
  • Zinc Finger Protein EZNF 3 4
  • Transcription Factor 17 3 4
  • TCF17 3 4
  • EZNF 3 4
  • HKL1 3 4
  • Epididymis Luminal Protein 104 3
  • HEL104 3
  • TCF-17 4
  • KID-1 3
  • KID1 3

External Ids for ZNF354A Gene

Previous HGNC Symbols for ZNF354A Gene

  • TCF17

Previous GeneCards Identifiers for ZNF354A Gene

  • GC05M178289
  • GC05M179025
  • GC05M178206
  • GC05M178252
  • GC05M178071
  • GC05M178138
  • GC05M172864

Summaries for ZNF354A Gene

GeneCards Summary for ZNF354A Gene

ZNF354A (Zinc Finger Protein 354A) is a Protein Coding gene. Diseases associated with ZNF354A include Spondyloarthropathy 1. Among its related pathways are ERK Signaling and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF354B.

Additional gene information for ZNF354A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF354A Gene

Genomics for ZNF354A Gene

GeneHancer (GH) Regulatory Elements for ZNF354A Gene

Promoters and enhancers for ZNF354A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J178728 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 695.3 +0.6 637 2.5 ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 SP3 SP5 REST ZNF592 ZNF354A CLK4 PIR45014
GH05J178203 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.5 +521.0 520958 12.3 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 HNRNPAB ENSG00000247679 FAM193B ZNF879 LOC202181 ZNF354C CLK4 RMND5B ENSG00000254035 MXD3
GH05J178111 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 +610.6 610585 16.8 HDGF PKNOX1 SMAD1 ARNT ARID4B NEUROD1 SIN3A ZNF2 ZBTB7B IRF4 NSD1 ENSG00000247679 ZNF879 ZNF354B LOC202181 CLK4 N4BP3 FAM193B RMND5B HNRNPAB
GH05J179619 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 9.8 -891.6 -891571 6.1 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 HNRNPH1 MAML1 ZNF879 MRNIP RUFY1 ZNF354C ZFP2 GRM6 LOC100996419 ENSG00000254035
GH05J179696 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.2 -968.2 -968243 4.9 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC CANX GC05M179696 MAML1 HNRNPH1 ZNF354B RUFY1 MRNIP CNOT6 ZNF879 LOC101928445
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF354A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF354A gene promoter:
  • LCR-F1
  • Max1
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B

Genomic Locations for ZNF354A Gene

Genomic Locations for ZNF354A Gene
36,098 bases
Minus strand
19,182 bases
Minus strand

Genomic View for ZNF354A Gene

Genes around ZNF354A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF354A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF354A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF354A Gene

Proteins for ZNF354A Gene

  • Protein details for ZNF354A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 354A
    Protein Accession:
    Secondary Accessions:
    • Q9UNJ8

    Protein attributes for ZNF354A Gene

    605 amino acids
    Molecular mass:
    69237 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF354A Gene

Post-translational modifications for ZNF354A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF354A Gene

No data available for DME Specific Peptides for ZNF354A Gene

Domains & Families for ZNF354A Gene

Gene Families for ZNF354A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF354A Gene

Suggested Antigen Peptide Sequences for ZNF354A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF354A: view

Function for ZNF354A Gene

Phenotypes From GWAS Catalog for ZNF354A Gene

Gene Ontology (GO) - Molecular Function for ZNF354A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA,IBA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF354A: view
genes like me logo Genes that share phenotypes with ZNF354A: view

Animal Model Products

CRISPR Products

miRNA for ZNF354A Gene

miRTarBase miRNAs that target ZNF354A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF354A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF354A Gene

Localization for ZNF354A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF354A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF354A gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF354A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 23665872
GO:0005730 nucleolus IDA,IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF354A: view

Pathways & Interactions for ZNF354A Gene

genes like me logo Genes that share pathways with ZNF354A: view

Gene Ontology (GO) - Biological Process for ZNF354A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001666 response to hypoxia IEA --
GO:0001822 kidney development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
genes like me logo Genes that share ontologies with ZNF354A: view

No data available for SIGNOR curated interactions for ZNF354A Gene

Drugs & Compounds for ZNF354A Gene

(1) Drugs for ZNF354A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF354A: view

Transcripts for ZNF354A Gene

mRNA/cDNA for ZNF354A Gene

Unigene Clusters for ZNF354A Gene

Zinc finger protein 354A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF354A

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF354A Gene

No ASD Table

Relevant External Links for ZNF354A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF354A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF354A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF354A Gene

This gene is overexpressed in Lung (31.2), Plasma (27.7), and Platelet (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF354A Gene

Protein tissue co-expression partners for ZNF354A Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF354A Gene:


SOURCE GeneReport for Unigene cluster for ZNF354A Gene:


mRNA Expression by UniProt/SwissProt for ZNF354A Gene:

Tissue specificity: Expressed in kidney and inner ear.

Evidence on tissue expression from TISSUES for ZNF354A Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF354A: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF354A Gene

Orthologs for ZNF354A Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF354A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF354A 34 33
  • 98.57 (n)
(Bos Taurus)
Mammalia ZNF354A 34 33
  • 89.92 (n)
(Canis familiaris)
Mammalia ZNF354A 33
  • 88.45 (n)
-- 34
  • 45 (a)
-- 34
  • 43 (a)
(Mus musculus)
Mammalia Zfp354a 16 34 33
  • 85.72 (n)
(Rattus norvegicus)
Mammalia Zfp354a 33
  • 84.5 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 49 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)35Ea 35
  • 40 (a)
CG3407 35
  • 37 (a)
CG17568 35
  • 34 (a)
CG17803 35
  • 33 (a)
CG8484 35
  • 28 (a)
Species where no ortholog for ZNF354A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF354A Gene

Gene Tree for ZNF354A (if available)
Gene Tree for ZNF354A (if available)
Evolutionary constrained regions (ECRs) for ZNF354A: view image

Paralogs for ZNF354A Gene

Paralogs for ZNF354A Gene

(472) SIMAP similar genes for ZNF354A Gene using alignment to 4 proteins:

  • Z354A_HUMAN
  • Q86Y64_HUMAN
genes like me logo Genes that share paralogs with ZNF354A: view

Variants for ZNF354A Gene

Sequence variations from dbSNP and Humsavar for ZNF354A Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000180053 -- 178,716,542(-) T/C intron_variant
rs1000247933 -- 178,727,500(-) T/C intron_variant
rs1000261226 -- 178,721,621(-) A/G intron_variant
rs1000316196 -- 178,716,192(-) G/A intron_variant
rs1000350002 -- 178,716,743(-) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF354A Gene

Variant ID Type Subtype PubMed ID
esv3607724 CNV gain 21293372
esv3890769 CNV gain 25118596
nsv1120062 OTHER inversion 24896259
nsv964986 CNV duplication 23825009

Variation tolerance for ZNF354A Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.89; 35.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF354A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF354A Gene

Disorders for ZNF354A Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF354A Gene - From: LncRNADisease and DISEASES

Disorder Aliases PubMed IDs
spondyloarthropathy 1
  • spondyloarthropathy, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF354A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with ZNF354A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF354A Gene

Publications for ZNF354A Gene

  1. Cloning, expression and mapping of a novel human zinc-finger gene TCF17 homologous to rodent Kid1. (PMID: 9465904) Omori Y … Nakamura Y (Cytogenetics and cell genetics 1997) 2 3 4 22 58
  2. Molecular cloning of a zinc finger gene eZNF from a human inner ear cDNA library, and in situ expression pattern of its mouse homologue in mouse inner ear. (PMID: 9919311) Jacob AN … Kandpal RP (Somatic cell and molecular genetics 1998) 3 4 22 58
  3. Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1. (PMID: 23665872) Wang W … Huang Z (Cellular and molecular life sciences : CMLS 2013) 3 4 58
  4. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty SE … Australian Cancer Study (Ovarian Cancer) (PLoS genetics 2010) 3 44 58
  5. The tcf17 gene at chromosome 5q is not involved in the development of conventional renal cell carcinoma. (PMID: 10842194) Bugert P … Kovacs G (International journal of cancer 2000) 3 22 58

Products for ZNF354A Gene

Sources for ZNF354A Gene

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