Aliases for ZNF350 Gene

Aliases for ZNF350 Gene

  • Zinc Finger Protein 350 2 3 4 5
  • ZBRK1 2 3 4
  • Zinc Finger And BRCA1-Interacting Protein With A KRAB Domain 1 3 4
  • KRAB Zinc Finger Protein ZFQR 3 4
  • Zinc Finger Protein ZBRK1 3 4
  • ZFQR 2 3
  • ZNF350 5

External Ids for ZNF350 Gene

Previous GeneCards Identifiers for ZNF350 Gene

  • GC19M057143
  • GC19M057159
  • GC19M052468
  • GC19M052470

Summaries for ZNF350 Gene

GeneCards Summary for ZNF350 Gene

ZNF350 (Zinc Finger Protein 350) is a Protein Coding gene. Diseases associated with ZNF350 include Breast Medullary Carcinoma and Gastric Cardia Carcinoma. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is ZNF613.

UniProtKB/Swiss-Prot Summary for ZNF350 Gene

  • Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3.

Gene Wiki entry for ZNF350 Gene

Additional gene information for ZNF350 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF350 Gene

Genomics for ZNF350 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF350 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF350 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF350

Top Transcription factor binding sites by QIAGEN in the ZNF350 gene promoter:
  • Bach1
  • FOXL1

Genomic Locations for ZNF350 Gene

Genomic Locations for ZNF350 Gene
chr19:51,964,340-51,986,856
(GRCh38/hg38)
Size:
22,517 bases
Orientation:
Minus strand
chr19:52,467,593-52,490,109
(GRCh37/hg19)
Size:
22,517 bases
Orientation:
Minus strand

Genomic View for ZNF350 Gene

Genes around ZNF350 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF350 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF350 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF350 Gene

Proteins for ZNF350 Gene

  • Protein details for ZNF350 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZX5-ZN350_HUMAN
    Recommended name:
    Zinc finger protein 350
    Protein Accession:
    Q9GZX5
    Secondary Accessions:
    • Q96G73
    • Q9HAQ4

    Protein attributes for ZNF350 Gene

    Size:
    532 amino acids
    Molecular mass:
    60011 Da
    Quaternary structure:
    • Interacts with BRCA1. Interacts with RNF11.

neXtProt entry for ZNF350 Gene

Post-translational modifications for ZNF350 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF350 Gene

Domains & Families for ZNF350 Gene

Gene Families for ZNF350 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF350 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF350 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein ZBRK1 (ZN350_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9GZX5

UniProtKB/Swiss-Prot:

ZN350_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF350: view

Function for ZNF350 Gene

Molecular function for ZNF350 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Binds to a specific sequence, 5'-GGGxxxCAGxxxTTT-3', within GADD45 intron 3.

Phenotypes From GWAS Catalog for ZNF350 Gene

Gene Ontology (GO) - Molecular Function for ZNF350 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IBA 21873635
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA 11090615
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 11090615
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA,IDA 11090615
genes like me logo Genes that share ontologies with ZNF350: view
genes like me logo Genes that share phenotypes with ZNF350: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF350

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF350 Gene

Localization for ZNF350 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF350 Gene

Nucleus. Nucleus matrix. Note=Associated with the nuclear matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF350 gene
Compartment Confidence
nucleus 5
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF350 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 23665872
GO:0005654 nucleoplasm IDA,TAS --
GO:0016363 nuclear matrix IEA --
GO:0016604 nuclear body IDA --
GO:0017053 transcriptional repressor complex IDA 11090615
genes like me logo Genes that share ontologies with ZNF350: view

Pathways & Interactions for ZNF350 Gene

genes like me logo Genes that share pathways with ZNF350: view

Pathways by source for ZNF350 Gene

2 Reactome pathways for ZNF350 Gene
1 KEGG pathway for ZNF350 Gene

Gene Ontology (GO) - Biological Process for ZNF350 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 11090615
GO:0006355 regulation of transcription, DNA-templated IEA,IDA 11090615
GO:0045892 negative regulation of transcription, DNA-templated IDA 11090615
GO:0045944 positive regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with ZNF350: view

No data available for SIGNOR curated interactions for ZNF350 Gene

Drugs & Compounds for ZNF350 Gene

(1) Drugs for ZNF350 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ZNF350: view

Transcripts for ZNF350 Gene

mRNA/cDNA for ZNF350 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF350

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF350 Gene

No ASD Table

Relevant External Links for ZNF350 Gene

GeneLoc Exon Structure for
ZNF350

Expression for ZNF350 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF350 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF350

SOURCE GeneReport for Unigene cluster for ZNF350 Gene:

Hs.407694

mRNA Expression by UniProt/SwissProt for ZNF350 Gene:

Q9GZX5-ZN350_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for ZNF350 Gene

  • Kidney(4.2)
genes like me logo Genes that share expression patterns with ZNF350: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF350 Gene

Orthologs for ZNF350 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF350 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF350 30 31
  • 98.81 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF347 30
  • 81.45 (n)
-- 31
  • 76 (a)
OneToMany
ZNF350 31
  • 61 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia ZNF350 31
  • 46 (a)
OneToOne
Species where no ortholog for ZNF350 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF350 Gene

ENSEMBL:
Gene Tree for ZNF350 (if available)
TreeFam:
Gene Tree for ZNF350 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF350: view image

Paralogs for ZNF350 Gene

(468) SIMAP similar genes for ZNF350 Gene using alignment to 5 proteins:

  • ZN350_HUMAN
  • M0QY52_HUMAN
  • M0QYT6_HUMAN
  • M0R017_HUMAN
  • M0R1T8_HUMAN
genes like me logo Genes that share paralogs with ZNF350: view

Variants for ZNF350 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF350 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
712253 Benign: not provided 51,965,074(-) G/A MISSENSE_VARIANT
rs2278415 - p.Arg501Ser
rs2278420 - p.Leu66Pro
rs28997584 - p.Arg132Cys
rs3764539 - p.Glu406Lys

Additional dbSNP identifiers (rs#s) for ZNF350 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF350 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3626n100 CNV gain 25217958
dgv425n27 CNV gain 19166990
dgv6523n54 CNV gain 21841781
esv2242567 CNV deletion 18987734
esv2718779 CNV deletion 23290073
esv2758767 CNV gain+loss 17122850
nsv1125524 CNV deletion 24896259
nsv1140251 OTHER inversion 24896259
nsv525259 CNV loss 19592680
nsv580001 CNV gain 21841781
nsv580006 CNV loss 21841781
nsv833872 CNV loss 17160897

Variation tolerance for ZNF350 Gene

Residual Variation Intolerance Score: 91.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.96; 79.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF350 Gene

Human Gene Mutation Database (HGMD)
ZNF350
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF350

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF350 Gene

Disorders for ZNF350 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF350 Gene - From: DISEASES

Disorder Aliases PubMed IDs
breast medullary carcinoma
  • medullary breast carcinoma with lymphoid stroma
gastric cardia carcinoma
  • carcinoma of cardia of stomach
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF350

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with ZNF350: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF350 Gene

Publications for ZNF350 Gene

  1. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. (PMID: 11090615) Zheng L … Lee WH (Molecular cell 2000) 2 3 4 23
  2. Polymorphisms in BRCA1, BRCA1-interacting genes and susceptibility of breast cancer in Chinese women. (PMID: 19484476) Huo X … Tang J (Journal of cancer research and clinical oncology 2009) 3 23 41
  3. Genetic variants and haplotype analyses of the ZBRK1/ZNF350 gene in high-risk non BRCA1/2 French Canadian breast and ovarian cancer families. (PMID: 17764113) Desjardins S … Durocher F (International journal of cancer 2008) 3 23 41
  4. Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes. (PMID: 15113441) Sigurdson AJ … Struewing JP (BMC cancer 2004) 3 23 41
  5. Characterization of a novel zinc finger gene with increased expression in nondividing normal human cells. (PMID: 11161714) Ran Q … Pereira-Smith OM (Experimental cell research 2001) 2 3 4

Products for ZNF350 Gene

Sources for ZNF350 Gene