Aliases for ZNF35 Gene

Aliases for ZNF35 Gene

  • Zinc Finger Protein 35 2 3 4 5
  • Zinc Finger Protein 35 (Clone HF.10) 2 3
  • Zinc Finger Protein HF.10 3 4
  • Zfp105 2 3
  • HF.10 2 3
  • HF10 2 3
  • ZNF35 5

External Ids for ZNF35 Gene

Previous GeneCards Identifiers for ZNF35 Gene

  • GC03P044155
  • GC03P043870
  • GC03P044509
  • GC03P044650
  • GC03P044665
  • GC03P044690
  • GC03P044684
  • GC03P044807
  • GC03P045169
  • GC03P045202
  • GC03P045222
  • GC03P045284
  • GC03P044832
  • GC03P044906
  • GC03P044941
  • GC03P044985
  • GC03P045020
  • GC03P045060
  • GC03P045096
  • GC03P045132
  • GC03P045348

Summaries for ZNF35 Gene

GeneCards Summary for ZNF35 Gene

ZNF35 (Zinc Finger Protein 35) is a Protein Coding gene. Diseases associated with ZNF35 include Zinc Finger Protein 105. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ZFP37.

UniProtKB/Swiss-Prot Summary for ZNF35 Gene

  • May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation.

Gene Wiki entry for ZNF35 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF35 Gene

Genomics for ZNF35 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF35 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF35 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF35

Top Transcription factor binding sites by QIAGEN in the ZNF35 gene promoter:
  • AREB6
  • ARP-1
  • HNF-1
  • HNF-1A
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1a
  • MIF-1
  • NRF-2

Genomic Locations for ZNF35 Gene

Latest Assembly
chr3:44,648,732-44,660,791
(GRCh38/hg38)
Size:
12,060 bases
Orientation:
Plus strand

Previous Assembly
chr3:44,690,224-44,702,283
(GRCh37/hg19 by Entrez Gene)
Size:
12,060 bases
Orientation:
Plus strand

chr3:44,690,219-44,702,283
(GRCh37/hg19 by Ensembl)
Size:
12,065 bases
Orientation:
Plus strand

Genomic View for ZNF35 Gene

Genes around ZNF35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF35 Gene

Proteins for ZNF35 Gene

  • Protein details for ZNF35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13682-ZNF35_HUMAN
    Recommended name:
    Zinc finger protein 35
    Protein Accession:
    P13682
    Secondary Accessions:
    • B2RBU6
    • Q53Y54
    • Q96D01

    Protein attributes for ZNF35 Gene

    Size:
    527 amino acids
    Molecular mass:
    59089 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA85451.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAG37343.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA30268.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for ZNF35 Gene

Post-translational modifications for ZNF35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF35 Gene

No data available for DME Specific Peptides for ZNF35 Gene

Domains & Families for ZNF35 Gene

Gene Families for ZNF35 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF35 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF35 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50867, highly similar to Zinc finger protein 35 (B4DUB8_HUMAN)
  • Zinc finger protein HF.10 (ZNF35_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P13682

UniProtKB/Swiss-Prot:

ZNF35_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF35: view

Function for ZNF35 Gene

Molecular function for ZNF35 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation.
GENATLAS Biochemistry:
zinc finger protein 35,cHF.10 (C2H2 type,Kruppel-like),expressed in testis,involved in germ cell differentiation process

Phenotypes From GWAS Catalog for ZNF35 Gene

Gene Ontology (GO) - Molecular Function for ZNF35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IBA 21873635
GO:0003677 DNA binding TAS 2108922
GO:0003700 DNA-binding transcription factor activity IDA 1572646
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with ZNF35: view
genes like me logo Genes that share phenotypes with ZNF35: view

miRNA for ZNF35 Gene

miRTarBase miRNAs that target ZNF35

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF35

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF35 Gene

Localization for ZNF35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF35 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF35 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IBA --
GO:0005634 nucleus IEA,IDA 20186958
GO:0048471 perinuclear region of cytoplasm IDA 20186958
genes like me logo Genes that share ontologies with ZNF35: view

Pathways & Interactions for ZNF35 Gene

PathCards logo

SuperPathways for ZNF35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated TAS 2108922
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0007283 spermatogenesis ISS 20186958
GO:0071300 cellular response to retinoic acid ISS 20186958
genes like me logo Genes that share ontologies with ZNF35: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF35 Gene

Drugs & Compounds for ZNF35 Gene

No Compound Related Data Available

Transcripts for ZNF35 Gene

mRNA/cDNA for ZNF35 Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF35

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF35 Gene

No ASD Table

Relevant External Links for ZNF35 Gene

GeneLoc Exon Structure for
ZNF35

Expression for ZNF35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF35 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF35 Gene



Protein tissue co-expression partners for ZNF35 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF35

SOURCE GeneReport for Unigene cluster for ZNF35 Gene:

Hs.288658

Evidence on tissue expression from TISSUES for ZNF35 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with ZNF35: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF35 Gene

Orthologs for ZNF35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF35 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF35 30 31
  • 99.68 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia ZNF35 30 31
  • 90.64 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia ZNF35 30 31
  • 86.78 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Zfp105 30
  • 85.56 (n)
Mouse
(Mus musculus)
Mammalia Zfp105 30 17 31
  • 84.48 (n)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii BX005448.1 31
  • 39 (a)
ManyToMany
zgc:174700 31
  • 39 (a)
ManyToMany
gb:am422109 31
  • 39 (a)
ManyToMany
BX890548.2 31
  • 39 (a)
ManyToMany
si:dkey-56m15.3 31
  • 39 (a)
ManyToMany
si:ch211-283l16.1 31
  • 39 (a)
ManyToMany
BX004879.1 31
  • 39 (a)
ManyToMany
si:ch211-226o13.2 31
  • 38 (a)
ManyToMany
si:dkey-22h13.2 31
  • 38 (a)
ManyToMany
CABZ01008480.1 31
  • 38 (a)
ManyToMany
CT573263.3 31
  • 38 (a)
ManyToMany
si:dkey-54j5.2 31
  • 37 (a)
ManyToMany
si:dkey-237m9.1 31
  • 37 (a)
ManyToMany
si:dkey-16b10.2 31
  • 36 (a)
ManyToMany
zgc:173714 31
  • 36 (a)
ManyToMany
CR293532.1 31
  • 36 (a)
ManyToMany
zgc:174694 31
  • 36 (a)
ManyToMany
BX005448.2 31
  • 32 (a)
ManyToMany
Species where no ortholog for ZNF35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF35 Gene

ENSEMBL:
Gene Tree for ZNF35 (if available)
TreeFam:
Gene Tree for ZNF35 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF35: view image

Paralogs for ZNF35 Gene

(523) SIMAP similar genes for ZNF35 Gene using alignment to 5 proteins:

  • ZNF35_HUMAN
  • B4DUB8_HUMAN
  • C9J011_HUMAN
  • C9JGR2_HUMAN
  • C9JGS9_HUMAN

Pseudogenes.org Pseudogenes for ZNF35 Gene

genes like me logo Genes that share paralogs with ZNF35: view

Variants for ZNF35 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF35 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNF35 Gene

Variant ID Type Subtype PubMed ID
esv3596037 CNV gain 21293372

Variation tolerance for ZNF35 Gene

Residual Variation Intolerance Score: 51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.43; 90.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF35

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF35 Gene

Disorders for ZNF35 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF35 Gene - From: GCD

Disorder Aliases PubMed IDs
zinc finger protein 105
  • znf105
- elite association - COSMIC cancer census association via MalaCards
Search ZNF35 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for ZNF35

genes like me logo Genes that share disorders with ZNF35: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF35 Gene

Publications for ZNF35 Gene

  1. Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22. (PMID: 1572646) Lanfrancone L … Pelicci PG (Genomics 1992) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers. (PMID: 2108922) Donti E … Pelicci PG (Human genetics 1990) 2 3
  4. Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation. (PMID: 3380682) Pannuti A … Lania L (Nucleic acids research 1988) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for ZNF35 Gene

Sources for ZNF35 Gene