Aliases for ZNF346 Gene
External Ids for ZNF346 Gene
Previous GeneCards Identifiers for ZNF346 Gene
The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
GeneCards Summary for ZNF346 Gene
ZNF346 (Zinc Finger Protein 346) is a Protein Coding gene. Diseases associated with ZNF346 include Hydrolethalus Syndrome 1 and Cardiac Valvular Dysplasia, X-Linked. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and enzyme binding. An important paralog of this gene is ZMAT4.
UniProtKB/Swiss-Prot Summary for ZNF346 Gene
Binds with low affinity to dsDNA and ssRNA, and with high affinity to dsRNA, with no detectable sequence specificity (PubMed:24521053). May bind to specific miRNA hairpins (PubMed:28431233).