Aliases for ZNF345 Gene

Aliases for ZNF345 Gene

  • Zinc Finger Protein 345 2 3 4 5
  • Zinc Finger Protein HZF10 3 4
  • HZF10 2 3
  • ZNF345 5

External Ids for ZNF345 Gene

Previous GeneCards Identifiers for ZNF345 Gene

  • GC19P038019
  • GC19P037801
  • GC19P042017
  • GC19P042033
  • GC19P037341
  • GC19P033809

Summaries for ZNF345 Gene

GeneCards Summary for ZNF345 Gene

ZNF345 (Zinc Finger Protein 345) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF283.

UniProtKB/Swiss-Prot Summary for ZNF345 Gene

Additional gene information for ZNF345 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF345 Gene

Genomics for ZNF345 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF345 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF345 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF345

Genomic Locations for ZNF345 Gene

Genomic Locations for ZNF345 Gene
chr19:36,850,350-36,913,029
(GRCh38/hg38)
Size:
62,680 bases
Orientation:
Plus strand
chr19:37,341,260-37,403,931
(GRCh37/hg19)
Size:
62,672 bases
Orientation:
Plus strand

Genomic View for ZNF345 Gene

Genes around ZNF345 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF345 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF345 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF345 Gene

Proteins for ZNF345 Gene

  • Protein details for ZNF345 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14585-ZN345_HUMAN
    Recommended name:
    Zinc finger protein 345
    Protein Accession:
    Q14585

    Protein attributes for ZNF345 Gene

    Size:
    488 amino acids
    Molecular mass:
    55383 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF345 Gene

Post-translational modifications for ZNF345 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF345 Gene

Domains & Families for ZNF345 Gene

Gene Families for ZNF345 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF345 Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF345 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51247, highly similar to Zinc finger protein 345 (B7Z4L5_HUMAN)
  • Zinc finger protein HZF10 (ZN345_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14585

UniProtKB/Swiss-Prot:

ZN345_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF345: view

Function for ZNF345 Gene

Molecular function for ZNF345 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF345 Gene

Gene Ontology (GO) - Molecular Function for ZNF345 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF345: view
genes like me logo Genes that share phenotypes with ZNF345: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF345

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF345 Gene

Localization for ZNF345 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF345 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF345 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ZNF345 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF345: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF345 Gene

Pathways & Interactions for ZNF345 Gene

PathCards logo

SuperPathways for ZNF345 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF345 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II TAS 9278146
GO:0006359 regulation of transcription by RNA polymerase III TAS 9278146
GO:0006366 transcription by RNA polymerase II TAS 9278146
GO:0006383 transcription by RNA polymerase III TAS 9278146
GO:0010468 regulation of gene expression IBA 21873635
genes like me logo Genes that share ontologies with ZNF345: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF345 Gene

Drugs & Compounds for ZNF345 Gene

No Compound Related Data Available

Transcripts for ZNF345 Gene

mRNA/cDNA for ZNF345 Gene

5 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF345

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF345 Gene

No ASD Table

Relevant External Links for ZNF345 Gene

GeneLoc Exon Structure for
ZNF345

Expression for ZNF345 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF345 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF345

SOURCE GeneReport for Unigene cluster for ZNF345 Gene:

Hs.362324
genes like me logo Genes that share expression patterns with ZNF345: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF345 Gene

Orthologs for ZNF345 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF345 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF345 30
  • 99.73 (n)
Cow
(Bos Taurus)
Mammalia ZNF345 30
  • 92.73 (n)
ZNF383 31
  • 43 (a)
ManyToMany
Dog
(Canis familiaris)
Mammalia ZNF571 30
  • 89.88 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 40 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta CG7987 32
  • 33 (a)
Species where no ortholog for ZNF345 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF345 Gene

ENSEMBL:
Gene Tree for ZNF345 (if available)
TreeFam:
Gene Tree for ZNF345 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF345: view image

Paralogs for ZNF345 Gene

Paralogs for ZNF345 Gene

(558) SIMAP similar genes for ZNF345 Gene using alignment to 7 proteins:

  • ZN345_HUMAN
  • E9PLT7_HUMAN
  • F8W8R5_HUMAN
  • K7EKZ8_HUMAN
  • K7EM63_HUMAN
  • K7EQ01_HUMAN
  • K7ESK8_HUMAN
genes like me logo Genes that share paralogs with ZNF345: view

Variants for ZNF345 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF345 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
787487 Benign: not provided 36,878,280(+) T/C SYNONYMOUS_VARIANT
789119 Benign: not provided 36,877,633(+) G/C MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for ZNF345 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF345 Gene

Variant ID Type Subtype PubMed ID
esv3644273 CNV loss 21293372
nsv1064851 CNV loss 25217958
nsv458569 CNV loss 19166990
nsv521605 CNV loss 19592680
nsv523848 CNV loss 19592680
nsv524754 CNV loss 19592680
nsv579461 CNV gain 21841781
nsv579462 CNV loss 21841781
nsv817833 CNV loss 17921354
nsv819209 CNV loss 19587683

Variation tolerance for ZNF345 Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF345 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF345

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF345 Gene

Disorders for ZNF345 Gene

No disorders were found for ZNF345 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF345 Gene

Publications for ZNF345 Gene

  1. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. (PMID: 7865130) Abrink M … Hellman L (DNA and cell biology 1995) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3

Products for ZNF345 Gene

Sources for ZNF345 Gene