Aliases for ZNF343 Gene

Aliases for ZNF343 Gene

  • Zinc Finger Protein 343 2 3 4 5
  • DJ734P14.5 3
  • MGC10715 2
  • ZNF343 5

External Ids for ZNF343 Gene

Previous GeneCards Identifiers for ZNF343 Gene

  • GC00U991036
  • GC20M002411
  • GC20M002412
  • GC20M002413
  • GC20M002414
  • GC20M002415
  • GC20M002416
  • GC20M002417
  • GC20M002418
  • GC20M002419
  • GC20M002420
  • GC20M002447
  • GC20M002462

Summaries for ZNF343 Gene

GeneCards Summary for ZNF343 Gene

ZNF343 (Zinc Finger Protein 343) is a Protein Coding gene. Diseases associated with ZNF343 include Testicular Leukemia. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF875.

UniProtKB/Swiss-Prot Summary for ZNF343 Gene

Additional gene information for ZNF343 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF343 Gene

Genomics for ZNF343 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF343 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J002507 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 612.7 +15.9 15901 2.8 HNRNPL CREB1 PRDM10 ZNF629 TFE3 SIX5 IKZF1 POLR2A ZNF7 JUND ZNF343 ENSG00000256566 lnc-TMC2-5 SNRPB TMC2 NOP56 SNORD56 SNORD57 ENSG00000228293 IDH3B
GH20J002523 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 600.7 -0.5 -487 2.5 GATAD2A CTCF PRDM10 RFX1 IKZF1 NFKBIZ ZNF692 LARP7 PRDM1 DDX20 ZNF343 lnc-TMC2-4 TMC2
GH20J002522 Enhancer 0.5 Ensembl 600.7 +1.7 1701 0.4 RFX1 DDX20 ZNF592 STAT1 HDAC2 KDM1A SP1 ESRRA ZNF343 lnc-TMC2-4 ENSG00000256566 lnc-TMC2-5
GH20J002468 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 37.5 +54.7 54712 3.6 SP1 HNRNPL CREB1 GATAD2A PRDM10 ZNF629 TFE3 SIX5 LEF1 SOX13 SNRPB lnc-TGM6-5 VPS16 ZNF343 NOP56 STK35 PCED1A UBOX5 SNORD119 ENSG00000256566
GH20J002101 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 34.3 +421.6 421601 4.2 SP1 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 RFX1 LEF1 STK35 lnc-PDYN-2 VPS16 SNRPB ZNF343 ACTG1P3 NOP56 ENSG00000229728 PCED1A SDCBP2-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF343 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF343

Top Transcription factor binding sites by QIAGEN in the ZNF343 gene promoter:
  • CUTL1
  • GATA-1

Genomic Locations for ZNF343 Gene

Genomic Locations for ZNF343 Gene
chr20:2,481,817-2,524,702
(GRCh38/hg38)
Size:
42,886 bases
Orientation:
Minus strand
chr20:2,462,463-2,505,348
(GRCh37/hg19)
Size:
42,886 bases
Orientation:
Minus strand

Genomic View for ZNF343 Gene

Genes around ZNF343 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF343 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF343 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF343 Gene

Proteins for ZNF343 Gene

  • Protein details for ZNF343 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P1L6-ZN343_HUMAN
    Recommended name:
    Zinc finger protein 343
    Protein Accession:
    Q6P1L6
    Secondary Accessions:
    • Q5JXU8
    • Q5JXU9
    • Q8N8F2
    • Q96EX8
    • Q96NA5
    • Q9BQB0

    Protein attributes for ZNF343 Gene

    Size:
    599 amino acids
    Molecular mass:
    69220 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF343 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF343 Gene

Post-translational modifications for ZNF343 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF343 Gene

Domains & Families for ZNF343 Gene

Gene Families for ZNF343 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF343 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF343 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 343 (ZN343_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q6P1L6

UniProtKB/Swiss-Prot:

ZN343_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF343: view

Function for ZNF343 Gene

Molecular function for ZNF343 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF343 Gene

Gene Ontology (GO) - Molecular Function for ZNF343 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZNF343: view
genes like me logo Genes that share phenotypes with ZNF343: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF343

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF343 Gene

Localization for ZNF343 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF343 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF343 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF343 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF343: view

Pathways & Interactions for ZNF343 Gene

genes like me logo Genes that share pathways with ZNF343: view

Pathways by source for ZNF343 Gene

2 Reactome pathways for ZNF343 Gene
1 KEGG pathway for ZNF343 Gene

Interacting Proteins for ZNF343 Gene

Gene Ontology (GO) - Biological Process for ZNF343 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF343: view

No data available for SIGNOR curated interactions for ZNF343 Gene

Drugs & Compounds for ZNF343 Gene

No Compound Related Data Available

Transcripts for ZNF343 Gene

mRNA/cDNA for ZNF343 Gene

11 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF343

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF343 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - - - - - -
SP2: - - - - -
SP3: - -
SP4: -
SP5:

Relevant External Links for ZNF343 Gene

GeneLoc Exon Structure for
ZNF343

Expression for ZNF343 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF343 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF343 Gene



Protein tissue co-expression partners for ZNF343 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF343

SOURCE GeneReport for Unigene cluster for ZNF343 Gene:

Hs.516846

Evidence on tissue expression from TISSUES for ZNF343 Gene

  • Kidney(4.2)
  • Lung(4.1)
  • Skin(4.1)
  • Blood(3.2)
genes like me logo Genes that share expression patterns with ZNF343: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF343 Gene

Orthologs for ZNF343 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ZNF343 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF343 30 31
  • 99.61 (n)
OneToOne
Species where no ortholog for ZNF343 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF343 Gene

ENSEMBL:
Gene Tree for ZNF343 (if available)
TreeFam:
Gene Tree for ZNF343 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF343: view image

Paralogs for ZNF343 Gene

(461) SIMAP similar genes for ZNF343 Gene using alignment to 1 proteins:

  • ZN343_HUMAN

Pseudogenes.org Pseudogenes for ZNF343 Gene

genes like me logo Genes that share paralogs with ZNF343: view

Variants for ZNF343 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF343 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs6049415 - p.Pro520Leu

Additional dbSNP identifiers (rs#s) for ZNF343 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF343 Gene

Variant ID Type Subtype PubMed ID
dgv40e213 CNV gain 24956385
esv1004398 CNV loss 20482838
esv2758778 CNV gain 17122850
esv3644998 CNV gain 21293372
esv3893269 CNV loss 25118596
nsv3260 CNV insertion 18451855
nsv470535 CNV gain 18288195

Variation tolerance for ZNF343 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.17; 61.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF343 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF343

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF343 Gene

Disorders for ZNF343 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF343 Gene - From: DISEASES

Disorder Aliases PubMed IDs
testicular leukemia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF343

genes like me logo Genes that share disorders with ZNF343: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF343 Gene

Publications for ZNF343 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4

Products for ZNF343 Gene

Sources for ZNF343 Gene