Aliases for ZNF341 Gene

Aliases for ZNF341 Gene

  • Zinc Finger Protein 341 2 3 4 5
  • HIES3 3

External Ids for ZNF341 Gene

Previous GeneCards Identifiers for ZNF341 Gene

  • GC20P032087
  • GC20P032988
  • GC20P033035
  • GC20P031783
  • GC20P032319
  • GC20P029105

Summaries for ZNF341 Gene

GeneCards Summary for ZNF341 Gene

ZNF341 (Zinc Finger Protein 341) is a Protein Coding gene. Diseases associated with ZNF341 include Hyper-Ige Recurrent Infection Syndrome 3, Autosomal Recessive and Chronic Mucocutaneous Candidiasis. Gene Ontology (GO) annotations related to this gene include nucleic acid binding.

UniProtKB/Swiss-Prot Summary for ZNF341 Gene

  • Transcriptional activator of STAT3 involved in the regulation of immune homeostasis. Also able to activate STAT1 transcription.

Additional gene information for ZNF341 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF341 Gene

Genomics for ZNF341 Gene

GeneHancer (GH) Regulatory Elements for ZNF341 Gene

Promoters and enhancers for ZNF341 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF341 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF341 gene promoter:
  • AREB6
  • ARP-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • MyoD
  • Nkx5-1
  • Sox9
  • SRY
  • STAT5A
  • TGIF

Genomic Locations for ZNF341 Gene

Genomic Locations for ZNF341 Gene
chr20:33,731,657-33,792,269
(GRCh38/hg38)
Size:
60,613 bases
Orientation:
Plus strand
chr20:32,319,463-32,380,075
(GRCh37/hg19)
Size:
60,613 bases
Orientation:
Plus strand

Genomic View for ZNF341 Gene

Genes around ZNF341 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF341 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF341 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF341 Gene

Proteins for ZNF341 Gene

  • Protein details for ZNF341 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYN7-ZN341_HUMAN
    Recommended name:
    Zinc finger protein 341
    Protein Accession:
    Q9BYN7
    Secondary Accessions:
    • A2RUF4
    • B2RXE5
    • B7ZM09
    • Q5JXM8
    • Q96ST5

    Protein attributes for ZNF341 Gene

    Size:
    854 amino acids
    Molecular mass:
    92728 Da
    Quaternary structure:
    • Binds DNA and to the STAT3 promoter.
    SequenceCaution:
    • Sequence=BAB55193.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF341 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF341 Gene

Post-translational modifications for ZNF341 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF341 Gene

No data available for DME Specific Peptides for ZNF341 Gene

Domains & Families for ZNF341 Gene

Gene Families for ZNF341 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF341 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF341 Gene

GenScript: Design optimal peptide antigens:
  • ZNF341 protein (Q504V9_HUMAN)
  • Zinc finger protein 341 (ZN341_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9BYN7

UniProtKB/Swiss-Prot:

ZN341_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF341: view

Function for ZNF341 Gene

Molecular function for ZNF341 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator of STAT3 involved in the regulation of immune homeostasis. Also able to activate STAT1 transcription.

Phenotypes From GWAS Catalog for ZNF341 Gene

Gene Ontology (GO) - Molecular Function for ZNF341 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001216 bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding IDA 29907690
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IBA,IDA 29907690
GO:0003700 DNA-binding transcription factor activity IBA 21873635
genes like me logo Genes that share ontologies with ZNF341: view
genes like me logo Genes that share phenotypes with ZNF341: view

Human Phenotype Ontology for ZNF341 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ZNF341 Gene

MGI Knock Outs for ZNF341:
  • Zfp341 Zfp341<tm1a(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for ZNF341 Gene

miRTarBase miRNAs that target ZNF341

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ZNF341 Gene

Localization for ZNF341 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF341 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF341 gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF341 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IDA 29907690
genes like me logo Genes that share ontologies with ZNF341: view

Pathways & Interactions for ZNF341 Gene

PathCards logo

SuperPathways for ZNF341 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF341 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IBA 21873635
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF341: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF341 Gene

Drugs & Compounds for ZNF341 Gene

No Compound Related Data Available

Transcripts for ZNF341 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF341 Gene

No ASD Table

Relevant External Links for ZNF341 Gene

GeneLoc Exon Structure for
ZNF341
ECgene alternative splicing isoforms for
ZNF341

Expression for ZNF341 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF341 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF341 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF341 Gene



Protein tissue co-expression partners for ZNF341 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF341 Gene:

ZNF341

SOURCE GeneReport for Unigene cluster for ZNF341 Gene:

Hs.516989
genes like me logo Genes that share expression patterns with ZNF341: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF341 Gene

Orthologs for ZNF341 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF341 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF341 33 32
  • 99.61 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF341 33 32
  • 90.52 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF341 33 32
  • 90.39 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zfp341 17 33 32
  • 86.26 (n)
rat
(Rattus norvegicus)
Mammalia Zfp966 32
  • 86.13 (n)
oppossum
(Monodelphis domestica)
Mammalia ZNF341 33
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ZNF341 33
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZNF341 33 32
  • 75.3 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZNF341 33
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf341 32
  • 64.3 (n)
zebrafish
(Danio rerio)
Actinopterygii znf341 33 32
  • 67.61 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1289 33
  • 30 (a)
OneToOne
Species where no ortholog for ZNF341 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF341 Gene

ENSEMBL:
Gene Tree for ZNF341 (if available)
TreeFam:
Gene Tree for ZNF341 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF341: view image

Paralogs for ZNF341 Gene

(30) SIMAP similar genes for ZNF341 Gene using alignment to 4 proteins:

  • ZN341_HUMAN
  • E9PN62_HUMAN
  • E9PQQ0_HUMAN
  • Q504V9_HUMAN

Pseudogenes.org Pseudogenes for ZNF341 Gene

genes like me logo Genes that share paralogs with ZNF341: view

No data available for Paralogs for ZNF341 Gene

Variants for ZNF341 Gene

Sequence variations from dbSNP and Humsavar for ZNF341 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1568940507 pathogenic, HYPER-IgE RECURRENT INFECTION SYNDROME 3, AUTOSOMAL RECESSIVE 33,753,265(+) C/T coding_sequence_variant, non_coding_transcript_variant, stop_gained
rs1568945329 pathogenic, HYPER-IgE RECURRENT INFECTION SYNDROME 3, AUTOSOMAL RECESSIVE 33,761,916(+) G/ coding_sequence_variant, frameshift, non_coding_transcript_variant
rs368945563 likely-benign, Long QT syndrome 33,791,116(+) C/T coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs376598954 pathogenic, HYPER-IgE RECURRENT INFECTION SYNDROME 3, AUTOSOMAL RECESSIVE 33,781,315(+) C/G/T coding_sequence_variant, intron_variant, non_coding_transcript_variant, stop_gained, synonymous_variant
rs746141726 pathogenic, HYPER-IgE RECURRENT INFECTION SYNDROME 3, AUTOSOMAL RECESSIVE 33,757,310(+) C/T coding_sequence_variant, non_coding_transcript_variant, stop_gained

Structural Variations from Database of Genomic Variants (DGV) for ZNF341 Gene

Variant ID Type Subtype PubMed ID
dgv2242n106 CNV deletion 24896259
esv2659244 CNV deletion 23128226
esv2676051 CNV deletion 23128226
esv3575370 CNV gain 25503493
nsv1065189 CNV loss 25217958
nsv1072535 CNV deletion 25765185
nsv180563 CNV deletion 16902084
nsv3353 CNV deletion 18451855
nsv3355 CNV insertion 18451855
nsv458965 CNV gain 19166990
nsv470548 CNV gain 18288195
nsv518926 CNV gain 19592680
nsv585930 CNV gain 21841781
nsv828714 CNV loss 20364138
nsv833961 CNV loss 17160897
nsv962572 CNV duplication 23825009

Variation tolerance for ZNF341 Gene

Residual Variation Intolerance Score: 54.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.72; 57.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF341 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF341

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF341 Gene

Disorders for ZNF341 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ZNF341 Gene - From: OMIM, ClinVar, GTR, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

ZN341_HUMAN
  • Hyper-IgE recurrent infection syndrome 3, autosomal recessive (HIES3) [MIM:618282]: An immunologic disorder characterized by skin bacterial infections in particular with Staphylococcus aureus, susceptibility to fungal infections such as chronic mucocutaneous candidiasis, atopic dermatitis, recurrent respiratory infections, bronchiectasis, and increased serum IgE and IgG. Immunologic work-up shows impaired differentiation of CD4+ T cells into T-helper 17 cells, decreased memory B cells, and often decreased NK cells. Some patients manifest extrahemapoietic features, including facial dysmorphism, abnormal dentition, alopecia, joint hypermobility and bone fractures. Disease onset is in early childhood. {ECO:0000269 PubMed:29907690, ECO:0000269 PubMed:29907691}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ZNF341

genes like me logo Genes that share disorders with ZNF341: view

No data available for Genatlas for ZNF341 Gene

Publications for ZNF341 Gene

  1. ZNF341 controls STAT3 expression and thereby immunocompetence. (PMID: 29907690) Frey-Jakobs S … Grimbacher B (Science immunology 2018) 3 4 56
  2. A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity. (PMID: 29907691) Béziat V … Casanova JL (Science immunology 2018) 3 4 56
  3. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 43 56
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 56
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 56

Products for ZNF341 Gene

Sources for ZNF341 Gene