Aliases for ZNF34 Gene

Aliases for ZNF34 Gene

  • Zinc Finger Protein 34 2 3 4 5
  • Zinc Finger Protein 34 (KOX 32) 2 3
  • Zinc Finger Protein KOX32 3 4
  • KOX32 3 4

External Ids for ZNF34 Gene

Previous GeneCards Identifiers for ZNF34 Gene

  • GC08U990067
  • GC08M146003
  • GC08M146002
  • GC08M145969
  • GC08M141115

Summaries for ZNF34 Gene

GeneCards Summary for ZNF34 Gene

ZNF34 (Zinc Finger Protein 34) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF527.

UniProtKB/Swiss-Prot Summary for ZNF34 Gene

Gene Wiki entry for ZNF34 Gene

Additional gene information for ZNF34 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF34 Gene

Genomics for ZNF34 Gene

GeneHancer (GH) Regulatory Elements for ZNF34 Gene

Promoters and enhancers for ZNF34 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J144785 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 513.5 -2.5 -2469 9.1 HNRNPK ZBTB40 ZNF217 EP300 CTCF TCF12 SIN3A MYC NRF1 POLR2G RPL8 ZNF34 piR-58885-002 ZNF7 CPSF1 VPS28 ZNF16 ZNF251 ENSG00000255182 GPAA1
GH08J144455 Enhancer 1 ENCODE 62.7 +330.9 330913 1.6 EP300 USF1 RBAK JUND FOS ZNF639 ZNF354C ZIC2 ZBTB10 ZNF623 lnc-TONSL-3 ZNF251 ZNF623 ZNF7 ZNF250 LRRC14 ZNF517 ZNF16 CPSF1 ZNF34
GH08J144077 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.7 +708.6 708630 3.5 ZBTB40 ZNF217 TCF12 SIN3A MYC NRF1 POLR2G SP1 NCOR1 GTF2E2 ENSG00000255224 MIR6847 EXOSC4 WDR97 ZNF7 CPSF1 ZNF623 ZNF16 LRRC14 MAF1
GH08J143968 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 9.7 +813.1 813119 11 ZNF217 CTCF TCF12 SIN3A NRF1 POLR2G USF1 SP1 NCOR1 ZFX PLEC WDR97 ZNF623 ZNF16 MIR661 ZNF7 PARP10 SPATC1 ZNF251 EXOSC4
GH08J144766 Enhancer 1 ENCODE 18.4 +19.5 19464 2.3 ZNF217 USF1 RBAK JUND FOS ZNF639 ZIC2 AFF1 REST CTBP1 HSALNG0069460 RPL8 ZNF34 ZNF251 ZNF517 LRRC14 ENSG00000255164 ZNF250 TMED10P1 GPAA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF34 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF34

Top Transcription factor binding sites by QIAGEN in the ZNF34 gene promoter:
  • C/EBPalpha
  • FAC1
  • MZF-1
  • N-Myc
  • NRF-2
  • Pax-3
  • TBP

Genomic Locations for ZNF34 Gene

Genomic Locations for ZNF34 Gene
chr8:144,772,224-144,787,359
(GRCh38/hg38)
Size:
15,136 bases
Orientation:
Minus strand
chr8:145,998,499-146,012,730
(GRCh37/hg19)
Size:
14,232 bases
Orientation:
Minus strand

Genomic View for ZNF34 Gene

Genes around ZNF34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF34 Gene

Proteins for ZNF34 Gene

  • Protein details for ZNF34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IZ26-ZNF34_HUMAN
    Recommended name:
    Zinc finger protein 34
    Protein Accession:
    Q8IZ26
    Secondary Accessions:
    • D3DWN1
    • Q9BSZ0

    Protein attributes for ZNF34 Gene

    Size:
    560 amino acids
    Molecular mass:
    64038 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH04480.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAH28136.1; Type=Miscellaneous discrepancy; Note=Codon in position 67 corresponds to a stop codon in genome.; Evidence={ECO:0000305};

neXtProt entry for ZNF34 Gene

Post-translational modifications for ZNF34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF34 Gene

Domains & Families for ZNF34 Gene

Gene Families for ZNF34 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF34 Gene

Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF34 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein KOX32 (ZNF34_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8IZ26

UniProtKB/Swiss-Prot:

ZNF34_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF34: view

Function for ZNF34 Gene

Molecular function for ZNF34 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 34 (KOX32) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF34 Gene

Gene Ontology (GO) - Molecular Function for ZNF34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF34: view
genes like me logo Genes that share phenotypes with ZNF34: view

Animal Model Products

CRISPR Products

miRNA for ZNF34 Gene

miRTarBase miRNAs that target ZNF34

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF34 Gene

Localization for ZNF34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF34 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF34 gene
Compartment Confidence
nucleus 5
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF34: view

Pathways & Interactions for ZNF34 Gene

genes like me logo Genes that share pathways with ZNF34: view

Pathways by source for ZNF34 Gene

2 Reactome pathways for ZNF34 Gene
1 KEGG pathway for ZNF34 Gene

Gene Ontology (GO) - Biological Process for ZNF34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF34: view

No data available for SIGNOR curated interactions for ZNF34 Gene

Drugs & Compounds for ZNF34 Gene

No Compound Related Data Available

Transcripts for ZNF34 Gene

mRNA/cDNA for ZNF34 Gene

3 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF34 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP1:
SP2:
SP3: - -
SP4: - -
SP5: - -
SP6: - -

Relevant External Links for ZNF34 Gene

GeneLoc Exon Structure for
ZNF34

Expression for ZNF34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF34 Gene

Protein differential expression in normal tissues from HIPED for ZNF34 Gene

This gene is overexpressed in Stomach (60.1) and Uterus (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF34 Gene



Protein tissue co-expression partners for ZNF34 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF34

SOURCE GeneReport for Unigene cluster for ZNF34 Gene:

Hs.631854

Evidence on tissue expression from TISSUES for ZNF34 Gene

  • Lung(4.2)
  • Nervous system(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with ZNF34: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF34 Gene

Orthologs for ZNF34 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF34 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF34 31 30
  • 99.69 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF34 31 30
  • 87.24 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF34 31 30
  • 84.3 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia znf180 30
  • 52.22 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6654 31
  • 22 (a)
OneToMany
Species where no ortholog for ZNF34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF34 Gene

ENSEMBL:
Gene Tree for ZNF34 (if available)
TreeFam:
Gene Tree for ZNF34 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF34: view image

Paralogs for ZNF34 Gene

(515) SIMAP similar genes for ZNF34 Gene using alignment to 3 proteins:

  • ZNF34_HUMAN
  • E9PNZ6_HUMAN
  • E9PSD0_HUMAN

Pseudogenes.org Pseudogenes for ZNF34 Gene

genes like me logo Genes that share paralogs with ZNF34: view

Variants for ZNF34 Gene

Additional dbSNP identifiers (rs#s) for ZNF34 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF34 Gene

Variant ID Type Subtype PubMed ID
nsv522459 CNV loss 19592680
nsv612969 CNV loss 21841781

Variation tolerance for ZNF34 Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.38; 76.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF34 Gene

Human Gene Mutation Database (HGMD)
ZNF34
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF34

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF34 Gene

Disorders for ZNF34 Gene

Additional Disease Information for ZNF34

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF34 Gene

Publications for ZNF34 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. A BanII RFLP in the ZNF34 zinc finger gene on chromosome 8. (PMID: 8104631) La Pillo B … Horsthemke B (Human molecular genetics 1993) 2 3 54
  4. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (PMID: 2014798) Huebner K … Thiesen HJ (American journal of human genetics 1991) 2 3 54
  5. ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest. (PMID: 29449217) Noguchi A … Kawahara H (Biology open 2018) 3 54

Products for ZNF34 Gene

Sources for ZNF34 Gene