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Aliases for ZNF34 Gene

Aliases for ZNF34 Gene

  • Zinc Finger Protein 34 2 3 5
  • Zinc Finger Protein 34 (KOX 32) 2 3
  • Zinc Finger Protein KOX32 3 4
  • KOX32 3 4

External Ids for ZNF34 Gene

Previous GeneCards Identifiers for ZNF34 Gene

  • GC08U990067
  • GC08M146003
  • GC08M146002
  • GC08M145969
  • GC08M141115

Summaries for ZNF34 Gene

GeneCards Summary for ZNF34 Gene

ZNF34 (Zinc Finger Protein 34) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF250.

UniProtKB/Swiss-Prot for ZNF34 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF34 Gene

Additional gene information for ZNF34 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF34 Gene

Genomics for ZNF34 Gene

GeneHancer (GH) Regulatory Elements for ZNF34 Gene

Promoters and enhancers for ZNF34 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I144785 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 563.6 -2.4 -2372 9 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 NFYC SSRP1 ZNF610 RPL8 ZNF34 PIR52884 VPS28 ZNF7 CPSF1 ZNF250 PARP10 COMMD5 LOC105375803
GH08I144782 Promoter 0.6 EPDnew 550.8 +4.5 4498 0.1 PRDM10 ZNF34 RN7SL395P LOC105375805
GH08I144455 Enhancer 1.3 Ensembl ENCODE 62.7 +330.9 330913 1.6 HDGF HNRNPUL1 PKNOX1 FOXA2 ARNT ZFP64 SIN3A ZNF2 POLR2B ZNF766 ZNF251 ZNF623 ZNF7 LRRC14 ZNF250 ZNF16 CPSF1 VPS28 ZNF517 ZNF34
GH08I143914 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 11.1 +850.2 850229 45.2 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 MEF2D PLEC ZNF251 ZNF517 ZNF250 ZNF7 LOC105375803 ZNF623 CPSF1 VPS28 LRRC14
GH08I144506 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.1 +278.4 278390 4 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 MFSD3 ZNF7 CPSF1 VPS28 ZNF250 ZNF623 ZNF251 ENSG00000254533 LRRC14 ZNF707
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF34 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF34 gene promoter:

Genomic Locations for ZNF34 Gene

Genomic Locations for ZNF34 Gene
15,136 bases
Minus strand

Genomic View for ZNF34 Gene

Genes around ZNF34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF34 Gene

Proteins for ZNF34 Gene

  • Protein details for ZNF34 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 34
    Protein Accession:
    Secondary Accessions:
    • D3DWN1
    • Q9BSZ0

    Protein attributes for ZNF34 Gene

    560 amino acids
    Molecular mass:
    64038 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH04480.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH28136.1; Type=Miscellaneous discrepancy; Note=Codon in position 67 corresponds to a stop codon in genome.; Evidence={ECO:0000305};

neXtProt entry for ZNF34 Gene

Post-translational modifications for ZNF34 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF34 Gene

Domains & Families for ZNF34 Gene

Gene Families for ZNF34 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins
  • Transcription factors

Protein Domains for ZNF34 Gene

Suggested Antigen Peptide Sequences for ZNF34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF34: view

Function for ZNF34 Gene

Molecular function for ZNF34 Gene

GENATLAS Biochemistry:
zinc finger protein 34 (KOX32) (C2H2 type,Kruppel-like)
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF34 Gene

Gene Ontology (GO) - Molecular Function for ZNF34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF34: view
genes like me logo Genes that share phenotypes with ZNF34: view

miRNA for ZNF34 Gene

miRTarBase miRNAs that target ZNF34

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF34 Gene

Localization for ZNF34 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF34 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF34 gene
Compartment Confidence
cytosol 5
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ZNF34: view

Pathways & Interactions for ZNF34 Gene

SuperPathways for ZNF34 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF34: view

Pathways by source for ZNF34 Gene

2 Reactome pathways for ZNF34 Gene

Gene Ontology (GO) - Biological Process for ZNF34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF34: view

No data available for SIGNOR curated interactions for ZNF34 Gene

Drugs & Compounds for ZNF34 Gene

No Compound Related Data Available

Transcripts for ZNF34 Gene

Unigene Clusters for ZNF34 Gene

Zinc finger protein 34:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF34 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e
SP3: - -
SP4: - -
SP5: - -
SP6: - -

Relevant External Links for ZNF34 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF34 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF34 Gene

Protein differential expression in normal tissues from HIPED for ZNF34 Gene

This gene is overexpressed in Stomach (60.1) and Uterus (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF34 Gene

Protein tissue co-expression partners for ZNF34 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF34 Gene:


SOURCE GeneReport for Unigene cluster for ZNF34 Gene:


Evidence on tissue expression from TISSUES for ZNF34 Gene

  • Lung(4.2)
  • Nervous system(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with ZNF34: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF34 Gene

Orthologs for ZNF34 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF34 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF34 34 33
  • 99.69 (n)
(Canis familiaris)
Mammalia ZNF34 33 34
  • 87.24 (n)
(Bos Taurus)
Mammalia ZNF34 34 33
  • 84.3 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia znf180 33
  • 52.22 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6654 34
  • 22 (a)
Species where no ortholog for ZNF34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF34 Gene

Gene Tree for ZNF34 (if available)
Gene Tree for ZNF34 (if available)

Paralogs for ZNF34 Gene

(515) SIMAP similar genes for ZNF34 Gene using alignment to 3 proteins: Pseudogenes for ZNF34 Gene

genes like me logo Genes that share paralogs with ZNF34: view

Variants for ZNF34 Gene

Sequence variations from dbSNP and Humsavar for ZNF34 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000245254 -- 144,773,198(-) G/A 3_prime_UTR_variant
rs1000484896 -- 144,787,528(-) G/A upstream_transcript_variant
rs1000587579 -- 144,783,106(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000747224 -- 144,781,088(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000769741 -- 144,777,896(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF34 Gene

Variant ID Type Subtype PubMed ID
nsv522459 CNV loss 19592680
nsv612969 CNV loss 21841781

Variation tolerance for ZNF34 Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.38; 76.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF34 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF34 Gene

Disorders for ZNF34 Gene

Additional Disease Information for ZNF34

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF34 Gene

Publications for ZNF34 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A BanII RFLP in the ZNF34 zinc finger gene on chromosome 8. (PMID: 8104631) La Pillo B … Horsthemke B (Human molecular genetics 1993) 2 3 58
  4. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (PMID: 2014798) Huebner K … Thiesen HJ (American journal of human genetics 1991) 2 3 58
  5. Novel variants in ZNF34 and other brain-expressed transcription factors are shared among early-onset MDD relatives. (PMID: 26823146) Subaran RL … Weissman MM (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2016) 3 58

Products for ZNF34 Gene

Sources for ZNF34 Gene

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