ZNF33B Gene (Protein Coding)

Zinc Finger Protein 33B

GC10M042574
GIFtS:
35
This gene encodes a member of the zinc finger family of proteins. This gene shows decreased expression in cumulus cells derived from patients undergoing controlled ovarian stimulation. This gene is present in a gene cluster with several related zinc finger genes in the pericentromeric region of chromosome 10. Pseudogenes have been identified on chromosomes 7 and 10. Alternative... See more...

Aliases for ZNF33B Gene

Aliases for ZNF33B Gene

  • Zinc Finger Protein 33B 2 3 4 5
  • KOX2 2 3 4
  • Zinc Finger Protein 33b (KOX 31) 2 3
  • Zinc Finger Protein 11B 2 4
  • ZNF11B 3 4
  • KOX31 2 3
  • Zinc Finger Protein 11b (KOX 2) 3
  • Zinc Finger Protein KOX2 4
  • ZNF33B 5

External Ids for ZNF33B Gene

Previous HGNC Symbols for ZNF33B Gene

  • ZNF11B

Previous GeneCards Identifiers for ZNF33B Gene

  • GC10M042377
  • GC10U900001
  • GC10P038188
  • GC07P006406
  • GC03P044571
  • GC10M042405
  • GC10M043069
  • GC10M039611
  • GC10M043084

Summaries for ZNF33B Gene

Entrez Gene Summary for ZNF33B Gene

  • This gene encodes a member of the zinc finger family of proteins. This gene shows decreased expression in cumulus cells derived from patients undergoing controlled ovarian stimulation. This gene is present in a gene cluster with several related zinc finger genes in the pericentromeric region of chromosome 10. Pseudogenes have been identified on chromosomes 7 and 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for ZNF33B Gene

ZNF33B (Zinc Finger Protein 33B) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF33A.

UniProtKB/Swiss-Prot Summary for ZNF33B Gene

Gene Wiki entry for ZNF33B Gene

Additional gene information for ZNF33B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF33B Gene

Genomics for ZNF33B Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for ZNF33B Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH10J042636 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 270 +0.2 212 3 CHD2 TBP MXD4 MNT IKZF1 SMAD5 IRF2 MBD2 ZNF217 POLR2A ZNF33B ENSG00000285884 LOC105378268 lnc-ZNF33B-3 piR-38773 LINC00839
GH10J042691 Promoter 0.6 EPDnew 250.2 -53.2 -53177 0.1 CTCF ZBTB33 CHD2 LINC01518 piR-56861 ZNF33B BMS1
GH10J043392 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 32.2 -763.1 -763119 18.3 ZSCAN16 CHD2 TBP SP1 ZBTB10 BCL11A MXD4 FEZF1 CEBPA NR2C1 HNRNPF RASGEF1A EIF3LP2 BMS1 ZNF32-AS2 ZNF37BP HNRNPA3P1 ZNF33B ZNF32-AS1 ZNF32
GH10J042781 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 12.6 -144.3 -144331 2.6 TBP ZBTB10 SP1 MXD4 FEZF1 SIX5 NR2C1 MNT SMAD5 ETS1 BMS1 lnc-ZNF33B-5 ZNF32-AS2 EIF3LP2 ZNF37BP ZNF32-AS1 HNRNPF CSGALNACT2-DT ZNF239 ZNF33B
GH10J043572 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.5 -936.2 -936233 3.9 TBP SP1 SIX5 NR2C1 MNT SMAD5 ETS1 IRF2 HES1 MBD2 ZNF239 ZNF32-AS2 BMS1 RASGEF1A ZNF33B ZNF32-AS1 ZNF487 lnc-ZNF239-1 ZNF485
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF33B on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for ZNF33B Gene

Latest Assembly
chr10:42,574,169-42,638,570
(GRCh38/hg38)
Size:
64,402 bases
Orientation:
Minus strand

Previous Assembly
chr10:43,069,617-43,134,018
(GRCh37/hg19 by Entrez Gene)
Size:
64,402 bases
Orientation:
Minus strand

chr10:43,084,555-43,133,992
(GRCh37/hg19 by Ensembl)
Size:
49,438 bases
Orientation:
Minus strand

Genomic View for ZNF33B Gene

Genes around ZNF33B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF33B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF33B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for ZNF33B Gene

Proteins for ZNF33B Gene

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  • Protein details for ZNF33B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06732-ZN33B_HUMAN
    Recommended name:
    Zinc finger protein 33B
    Protein Accession:
    Q06732
    Secondary Accessions:
    • Q06731
    • Q32MA2
    • Q86XY8
    • Q8NDW3

    Protein attributes for ZNF33B Gene

    Size:
    778 amino acids
    Molecular mass:
    90683 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH48313.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ZNF33B Gene

Protein Expression for ZNF33B Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for ZNF33B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF33B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF33B Gene

Domains & Families for ZNF33B Gene

Gene Families for ZNF33B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF33B Gene

InterPro:
Blocks:
  • C2H2-type zinc finger signature
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF33B Gene

GenScript: Design optimal peptide antigens:
  • ZNF33B protein (Q3B799_HUMAN)
  • ZNF33B protein (Q6P1A4_HUMAN)
  • Zinc finger protein KOX2 (ZN33B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q06732

UniProtKB/Swiss-Prot:

ZN33B_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF33B: view

Function for ZNF33B Gene

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Molecular function for ZNF33B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 33b (KOX31) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF33B Gene

Gene Ontology (GO) - Molecular Function for ZNF33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IBA 21873635
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ZNF33B: view
genes like me logo Genes that share phenotypes with ZNF33B: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF33B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF33B Gene

Localization for ZNF33B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF33B Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF33B gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nucleoli fibrillar center (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF33B: view

Pathways & Interactions for ZNF33B Gene

genes like me logo Genes that share pathways with ZNF33B: view

Pathways by source for ZNF33B Gene

2 Reactome pathways for ZNF33B Gene
1 KEGG pathway for ZNF33B Gene

Gene Ontology (GO) - Biological Process for ZNF33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0045944 positive regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF33B: view

No data available for SIGNOR curated interactions for ZNF33B Gene

Drugs & Compounds for ZNF33B Gene

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(1) Drugs for ZNF33B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 1687
genes like me logo Genes that share compounds with ZNF33B: view

Transcripts for ZNF33B Gene

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mRNA/cDNA for ZNF33B Gene

8 REFSEQ mRNAs :
27 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF33B

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF33B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: - - - -
SP8: - - - - -
SP9:

Relevant External Links for ZNF33B Gene

GeneLoc Exon Structure for
ZNF33B

Expression for ZNF33B Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF33B Gene

mRNA expression in normal human tissues for ZNF33B Gene
mRNA expression by BioGPS for ZNF33B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF33B Gene

This gene is overexpressed in Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF33B Gene

This gene is overexpressed in Ovary (54.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF33B Gene



Protein tissue co-expression partners for ZNF33B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF33B

SOURCE GeneReport for Unigene cluster for ZNF33B Gene:

Hs.732284

Evidence on tissue expression from TISSUES for ZNF33B Gene

  • Intestine(4.1)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with ZNF33B: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF33B Gene

Orthologs for ZNF33B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF33B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia ZNF33B 30 31
  • 99.4 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia -- 31
  • 86 (a)
 OneToMany
Dog
(Canis familiaris)
 Mammalia -- 31
  • 83 (a)
 OneToMany
Platypus
(Ornithorhynchus anatinus)
 Mammalia -- 31
  • 55 (a)
 ManyToMany
Mouse
(Mus musculus)
 Mammalia Zfp35 31
  • 46 (a)
 ManyToMany
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 41 (a)
 OneToMany
Chicken
(Gallus gallus)
 Aves -- 31
  • 37 (a)
 OneToMany
Lizard
(Anolis carolinensis)
 Reptilia -- 31
  • 37 (a)
 ManyToMany
Zebrafish
(Danio rerio)
 Actinopterygii BX004873.2 31
  • 45 (a)
 ManyToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 43 (a)
 ManyToMany
-- 31
  • 41 (a)
 ManyToMany
-- 31
  • 38 (a)
 ManyToMany
-- 31
  • 32 (a)
 ManyToMany
Species where no ortholog for ZNF33B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF33B Gene

ENSEMBL:
Gene Tree for ZNF33B (if available)
TreeFam:
Gene Tree for ZNF33B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF33B: view image

Paralogs for ZNF33B Gene

Paralogs for ZNF33B Gene

(487) SIMAP similar genes for ZNF33B Gene using alignment to 3 proteins:

  • ZN33B_HUMAN
  • Q3B799_HUMAN
  • Q6P1A4_HUMAN

Pseudogenes.org Pseudogenes for ZNF33B Gene

genes like me logo Genes that share paralogs with ZNF33B: view

Variants for ZNF33B Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF33B Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs138366584 Benign: not provided 42,593,386(-) A/C
NM_006955.3(ZNF33B):c.1564T>G (p.Leu522Val) 		MISSENSE
rs7914982 Benign: not provided. - 42,593,883(-) T/Cp.His356Arg
NM_006955.3(ZNF33B):c.1067A>G (p.His356Arg) 		MISSENSE
rs210280 - p.Arg145Cys

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for ZNF33B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for ZNF33B Gene

Variant ID Type Subtype PubMed ID
dgv1098n54 CNV gain 21841781
esv2669368 CNV deletion 23128226
esv2759746 CNV loss 17122850
esv34929 CNV loss 17911159
esv3623017 CNV loss 21293372
esv3623018 CNV gain 21293372
esv3623019 CNV loss 21293372
esv3891795 CNV gain 25118596
nsv1042764 CNV gain 25217958
nsv469725 CNV gain 16826518
nsv550672 CNV gain 21841781

Variation tolerance for ZNF33B Gene

Residual Variation Intolerance Score: 89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF33B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF33B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF33B Gene

Disorders for ZNF33B Gene

Additional Disease Information for ZNF33B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for ZNF33B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF33B Gene

Publications for ZNF33B Gene

  1. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. (PMID: 8464732) Tunnacliffe A … Ponder BA (Nucleic acids research 1993) 3 4 23
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 41
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. (PMID: 12566394) Guy J … Jackson MS (Genome research 2003) 3 4

ExternalLinks

View latest publications for ZNF33B gene in Mastermind

Products for ZNF33B Gene

Sources for ZNF33B Gene