Aliases for ZNF33A Gene

Aliases for ZNF33A Gene

  • Zinc Finger Protein 33A 2 3 4 5
  • Zinc Finger Protein 11A 2 3 4
  • KOX31 2 3 4
  • Zinc Finger And ZAK-Associated Protein With KRAB Domain 3 4
  • Zinc Finger Protein 33a (KOX 31) 2 3
  • Zinc Finger Protein KOX31 3 4
  • KIAA0065 2 4
  • ZNF11A 3 4
  • ZNF11 3 4
  • ZNF33 3 4
  • ZZAPK 2 3
  • KOX5 2 3
  • Zinc Finger And ZAK Associated Protein With KRAB Domain 2
  • Brain My041 Protein 3
  • FLJ23404 2
  • ZNF33A 5
  • NF11A 3
  • ZZaPK 4
  • KOX2 3

External Ids for ZNF33A Gene

Previous HGNC Symbols for ZNF33A Gene

  • ZNF33
  • ZNF11A

Previous GeneCards Identifiers for ZNF33A Gene

  • GC10P038322
  • GC10P038189
  • GC10P038177
  • GC10P038339

Summaries for ZNF33A Gene

GeneCards Summary for ZNF33A Gene

ZNF33A (Zinc Finger Protein 33A) is a Protein Coding gene. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF33B.

UniProtKB/Swiss-Prot Summary for ZNF33A Gene

Gene Wiki entry for ZNF33A Gene

Additional gene information for ZNF33A Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF33A Gene

Genomics for ZNF33A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF33A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J038009 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.4 430 3 HNRNPL CREB1 PRDM10 ZNF629 SIX5 SOX13 IKZF1 ZNF692 POLR2A BACH1 ZNF33A ZNF25 ZNF25-DT SEPTIN7P9 HSD17B7P2 RNU6-795P ZNF37A
GH10J037854 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 12.3 -153.5 -153482 4 SP1 CREB1 GATAD2A PRDM10 ZNF629 REST TFE3 ZNF512 SOX13 IKZF1 ENSG00000236514 LOC107984224 ZNF248 CICP9 ZNF25 ZNF33A SEPTIN7P9 ZNF25-DT HSD17B7P2 lnc-ZNF25-2
GH10J038025 Enhancer 0.6 Ensembl 0.4 +15.0 15017 0.6 ZNF143 RUNX3 BCL11A ELF1 NBN SPI1 SMARCA5 IRF4 KLF5 ZNF217 ZNF25 RNU6-795P ZNF33A ZNF37A
GH10J038054 Enhancer 0.7 Ensembl ENCODE 0.3 +44.0 43966 1.3 CEBPB ZNF316 FOS TRIM24 EP300 MAFK ATF4 ZNF248 ZNF37A piR-30293-001 RNU6-795P ZNF33A
GH10J038032 Enhancer 0.5 Ensembl 0.4 +22.6 22617 0.6 GABPA SP1 ATF3 YY1 RXRA ZNF25 RNU6-795P ZNF33A ZNF37A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF33A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF33A

Genomic Locations for ZNF33A Gene

Genomic Locations for ZNF33A Gene
57,352 bases
Plus strand
54,439 bases
Plus strand

Genomic View for ZNF33A Gene

Genes around ZNF33A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF33A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF33A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF33A Gene

Proteins for ZNF33A Gene

  • Protein details for ZNF33A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 33A
    Protein Accession:
    Secondary Accessions:
    • A8K9X9
    • B4E0M8
    • F6TH33
    • F8WAJ5
    • P17013
    • Q5VZ86

    Protein attributes for ZNF33A Gene

    810 amino acids
    Molecular mass:
    94384 Da
    Quaternary structure:
    • Interacts with MAP3K20/ZAK.

    Alternative splice isoforms for ZNF33A Gene


neXtProt entry for ZNF33A Gene

Post-translational modifications for ZNF33A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF33A Gene

Domains & Families for ZNF33A Gene

Gene Families for ZNF33A Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF33A Gene

  • C2H2-type zinc finger signature
  • KRAB box

Suggested Antigen Peptide Sequences for ZNF33A Gene

GenScript: Design optimal peptide antigens:
  • ZNF33A protein (A0AUX1_HUMAN)
  • ZNF33A protein (Q05D89_HUMAN)
  • ZNF33A protein (Q8N6F5_HUMAN)
  • cDNA: FLJ23404 fis, clone HEP18862 (Q9H5I4_HUMAN)
  • Zinc finger protein KOX31 (ZN33A_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF33A: view

Function for ZNF33A Gene

Molecular function for ZNF33A Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 33a (KOX31) (C2H2 type,Kruppel-like)

Gene Ontology (GO) - Molecular Function for ZNF33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity NAS 8464732
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF33A: view
genes like me logo Genes that share phenotypes with ZNF33A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF33A

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF33A Gene

Localization for ZNF33A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF33A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF33A gene
Compartment Confidence
nucleus 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nucleoli fibrillar center (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8464732
genes like me logo Genes that share ontologies with ZNF33A: view

Pathways & Interactions for ZNF33A Gene

genes like me logo Genes that share pathways with ZNF33A: view

Pathways by source for ZNF33A Gene

2 Reactome pathways for ZNF33A Gene
1 KEGG pathway for ZNF33A Gene

Gene Ontology (GO) - Biological Process for ZNF33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 8464732
genes like me logo Genes that share ontologies with ZNF33A: view

No data available for SIGNOR curated interactions for ZNF33A Gene

Drugs & Compounds for ZNF33A Gene

No Compound Related Data Available

Transcripts for ZNF33A Gene

mRNA/cDNA for ZNF33A Gene

20 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF33A

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF33A Gene

No ASD Table

Relevant External Links for ZNF33A Gene

GeneLoc Exon Structure for

Expression for ZNF33A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF33A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF33A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF33A Gene

Protein tissue co-expression partners for ZNF33A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF33A

SOURCE GeneReport for Unigene cluster for ZNF33A Gene:


Evidence on tissue expression from TISSUES for ZNF33A Gene

  • Bone marrow(4.1)
  • Nervous system(2.9)
  • Blood(2.5)
genes like me logo Genes that share expression patterns with ZNF33A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF33A Gene

Orthologs for ZNF33A Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF33A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF33A 30 31
  • 98.69 (n)
(Canis familiaris)
Mammalia LOC488951 30
  • 83.69 (n)
-- 31
  • 80 (a)
(Bos Taurus)
Mammalia -- 31
  • 82 (a)
(Monodelphis domestica)
Mammalia -- 31
  • 41 (a)
(Mus musculus)
Mammalia Gm13212 31
  • 40 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 38 (a)
(Gallus gallus)
Aves -- 31
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 53 (a)
(Danio rerio)
Actinopterygii si:dkey-54f18.1 31
  • 44 (a)
Fruit Fly
(Drosophila melanogaster)
Insecta CG5245 32
  • 40 (a)
CG3941 32
  • 32 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 43 (a)
-- 31
  • 42 (a)
-- 31
  • 39 (a)
-- 31
  • 33 (a)
Species where no ortholog for ZNF33A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for ZNF33A Gene

Gene Tree for ZNF33A (if available)
Gene Tree for ZNF33A (if available)
Evolutionary constrained regions (ECRs) for ZNF33A: view image

Paralogs for ZNF33A Gene

Paralogs for ZNF33A Gene

(547) SIMAP similar genes for ZNF33A Gene using alignment to 6 proteins:

  • F6TH33_HUMAN
  • Q05D89_HUMAN
  • Q8N6F5_HUMAN
  • Q9H5I4_HUMAN Pseudogenes for ZNF33A Gene

genes like me logo Genes that share paralogs with ZNF33A: view

Variants for ZNF33A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF33A Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
rs10508862 - p.Asp804His
rs12256916 - p.Gly614Arg
rs2505232 - p.Gln549Glu

Additional dbSNP identifiers (rs#s) for ZNF33A Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF33A Gene

Variant ID Type Subtype PubMed ID
esv3576438 CNV gain 25503493
esv3622975 CNV loss 21293372
nsv1040704 CNV gain 25217958
nsv550419 CNV gain 21841781
nsv947853 CNV duplication 23825009

Variation tolerance for ZNF33A Gene

Residual Variation Intolerance Score: 85.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.81; 83.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF33A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF33A Gene

Disorders for ZNF33A Gene

No disorders were found for ZNF33A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF33A Gene

Publications for ZNF33A Gene

  1. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. (PMID: 8464732) Tunnacliffe A … Ponder BA (Nucleic acids research 1993) 2 3 4 23
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4
  3. A novel zinc finger protein, ZZaPK, interacts with ZAK and stimulates the ZAK-expressing cells re-entering the cell cycle. (PMID: 12535642) Yang JJ (Biochemical and biophysical research communications 2003) 3 4
  4. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N … Tabata S (DNA research : an international journal for rapid publication of reports on genes and genomes 1994) 3 4
  5. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. (PMID: 2014798) Huebner K … Thiesen HJ (American journal of human genetics 1991) 2 3

Products for ZNF33A Gene

Sources for ZNF33A Gene