This gene encodes a zinc finger domain containing protein. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] See more...

Aliases for ZNF337 Gene

Aliases for ZNF337 Gene

  • Zinc Finger Protein 337 2 3 4 5
  • DJ694B14.1 2
  • ZNF337 5

External Ids for ZNF337 Gene

Previous GeneCards Identifiers for ZNF337 Gene

  • GC20M025642
  • GC20M025649
  • GC20M025602
  • GC20M025654
  • GC20M025612
  • GC20M025674
  • GC20M025677
  • GC20M025684

Summaries for ZNF337 Gene

Entrez Gene Summary for ZNF337 Gene

  • This gene encodes a zinc finger domain containing protein. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for ZNF337 Gene

ZNF337 (Zinc Finger Protein 337) is a Protein Coding gene. Diseases associated with ZNF337 include Corneal Dystrophy, Fleck and Adult Astrocytic Tumour. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF875.

UniProtKB/Swiss-Prot Summary for ZNF337 Gene

Additional gene information for ZNF337 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF337 Gene

Genomics for ZNF337 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for ZNF337 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF337 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF337

Genomic Locations for ZNF337 Gene

Genomic Locations for ZNF337 Gene
chr20:25,673,195-25,696,879
(GRCh38/hg38)
Size:
23,685 bases
Orientation:
Minus strand
chr20:25,654,851-25,677,477
(GRCh37/hg19)
Size:
22,627 bases
Orientation:
Minus strand

Genomic View for ZNF337 Gene

Genes around ZNF337 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF337 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF337 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF337 Gene

Proteins for ZNF337 Gene

  • Protein details for ZNF337 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y3M9-ZN337_HUMAN
    Recommended name:
    Zinc finger protein 337
    Protein Accession:
    Q9Y3M9
    Secondary Accessions:
    • B4DSM2
    • Q9Y3Y5

    Protein attributes for ZNF337 Gene

    Size:
    751 amino acids
    Molecular mass:
    86875 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF337 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF337 Gene

Post-translational modifications for ZNF337 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF337 Gene

No data available for DME Specific Peptides for ZNF337 Gene

Domains & Families for ZNF337 Gene

Gene Families for ZNF337 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF337 Gene

InterPro:
Blocks:
  • KRAB box
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF337 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53476, highly similar to Zinc finger protein 337 (B4DSM2_HUMAN)
  • cDNA FLJ43466 fis, clone OCBBF2036743, weakly similar to ZINC FINGER PROTEIN 133 (Q6ZUQ0_HUMAN)
  • Zinc finger protein 337 (ZN337_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9Y3M9

UniProtKB/Swiss-Prot:

ZN337_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF337: view

Function for ZNF337 Gene

Molecular function for ZNF337 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF337 Gene

Gene Ontology (GO) - Molecular Function for ZNF337 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IBA 21873635
genes like me logo Genes that share ontologies with ZNF337: view
genes like me logo Genes that share phenotypes with ZNF337: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF337

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF337 Gene

Localization for ZNF337 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF337 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF337 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF337 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF337: view

Pathways & Interactions for ZNF337 Gene

genes like me logo Genes that share pathways with ZNF337: view

Pathways by source for ZNF337 Gene

2 Reactome pathways for ZNF337 Gene
1 KEGG pathway for ZNF337 Gene

Gene Ontology (GO) - Biological Process for ZNF337 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF337: view

No data available for SIGNOR curated interactions for ZNF337 Gene

Drugs & Compounds for ZNF337 Gene

No Compound Related Data Available

Transcripts for ZNF337 Gene

mRNA/cDNA for ZNF337 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF337

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF337 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - - - -
SP6: - - - - - - - - - - -
SP7: -
SP8: - -
SP9: - - - - -

Relevant External Links for ZNF337 Gene

GeneLoc Exon Structure for
ZNF337

Expression for ZNF337 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF337 Gene

Protein differential expression in normal tissues from HIPED for ZNF337 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF337 Gene



Protein tissue co-expression partners for ZNF337 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF337

SOURCE GeneReport for Unigene cluster for ZNF337 Gene:

Hs.633621

Evidence on tissue expression from TISSUES for ZNF337 Gene

  • Nervous system(4.8)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF337: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF337 Gene

Orthologs for ZNF337 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF337 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia ZNF337 30 31
  • 99.82 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 40 (a)
ManyToMany
Species where no ortholog for ZNF337 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for ZNF337 Gene

ENSEMBL:
Gene Tree for ZNF337 (if available)
TreeFam:
Gene Tree for ZNF337 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF337: view image

Paralogs for ZNF337 Gene

(515) SIMAP similar genes for ZNF337 Gene using alignment to 2 proteins:

  • ZN337_HUMAN
  • B4DSM2_HUMAN

Pseudogenes.org Pseudogenes for ZNF337 Gene

genes like me logo Genes that share paralogs with ZNF337: view

Variants for ZNF337 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF337 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs16987972 - p.Arg467Gly
rs926487 - p.Val17Ile

Additional dbSNP identifiers (rs#s) for ZNF337 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF337 Gene

Variant ID Type Subtype PubMed ID
dgv4291n100 CNV gain 25217958
esv3567930 CNV loss 25503493
esv3575367 CNV gain 25503493
esv8845 CNV gain 19470904
nsv522873 CNV gain 19592680

Variation tolerance for ZNF337 Gene

Residual Variation Intolerance Score: 29.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.14; 80.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF337 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF337

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF337 Gene

Disorders for ZNF337 Gene

MalaCards: The human disease database

(3) MalaCards diseases for ZNF337 Gene - From: DISEASES

Disorder Aliases PubMed IDs
corneal dystrophy, fleck
  • cfd
adult astrocytic tumour
  • adult astrocytoma
stromal dystrophy
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with ZNF337: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF337 Gene

Publications for ZNF337 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4

Products for ZNF337 Gene

Sources for ZNF337 Gene