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Aliases for ZNF337 Gene

Aliases for ZNF337 Gene

  • Zinc Finger Protein 337 2 3 5

External Ids for ZNF337 Gene

Previous GeneCards Identifiers for ZNF337 Gene

  • GC20M025642
  • GC20M025649
  • GC20M025602
  • GC20M025654
  • GC20M025612

Summaries for ZNF337 Gene

Entrez Gene Summary for ZNF337 Gene

  • This gene encodes a zinc finger domain containing protein. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

GeneCards Summary for ZNF337 Gene

ZNF337 (Zinc Finger Protein 337) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is HKR1.

UniProtKB/Swiss-Prot for ZNF337 Gene

  • May be involved in transcriptional regulation.

Additional gene information for ZNF337 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF337 Gene

Genomics for ZNF337 Gene

GeneHancer (GH) Regulatory Elements for ZNF337 Gene

Promoters and enhancers for ZNF337 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20I025695 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 562.7 +0.4 369 2.1 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766 ZNF337 NANP ENSG00000278383
GH20I025622 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 25.9 +73.2 73224 2.9 PKNOX1 CLOCK ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 NANP ZNF337-AS1 ZNF337 NINL VN1R108P FAM182B RNU6ATAC17P
GH20I025232 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 24.1 +460.4 460384 7.8 PKNOX1 FOXA2 ARNT ARID4B NEUROD1 SIN3A FEZF1 ZNF2 YY1 ZNF766 LOC105372579 ABHD12 ZNF337 ZNF337-AS1 NANP PYGB NINL ENTPD6 FAM182B FAM182A
GH20I025584 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 14.3 +111.7 111740 2 FOXA2 ARID4B SIN3A DMAP1 ZNF48 SLC30A9 ZNF121 GLIS2 ELK1 KLF7 NINL PIR54986 PYGB ZNF337 FAM182A FAM182B
GH20I025245 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.3 +448.2 448225 6 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 PYGB LOC105372580 ABHD12 ENTPD6 ZNF337 FAM182A FAM182B ENSG00000274507
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF337 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF337 Gene

Genomic Locations for ZNF337 Gene
23,710 bases
Minus strand

Genomic View for ZNF337 Gene

Genes around ZNF337 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF337 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF337 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF337 Gene

Proteins for ZNF337 Gene

  • Protein details for ZNF337 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 337
    Protein Accession:
    Secondary Accessions:
    • B4DSM2
    • Q9Y3Y5

    Protein attributes for ZNF337 Gene

    751 amino acids
    Molecular mass:
    86875 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF337 Gene


neXtProt entry for ZNF337 Gene

Post-translational modifications for ZNF337 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF337 Gene

Domains & Families for ZNF337 Gene

Gene Families for ZNF337 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF337 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF337: view

Function for ZNF337 Gene

Molecular function for ZNF337 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF337 Gene

Gene Ontology (GO) - Molecular Function for ZNF337 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF337: view
genes like me logo Genes that share phenotypes with ZNF337: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF337 Gene

Localization for ZNF337 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF337 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF337 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF337 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF337: view

Pathways & Interactions for ZNF337 Gene

SuperPathways for ZNF337 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF337: view

Pathways by source for ZNF337 Gene

2 Reactome pathways for ZNF337 Gene

Gene Ontology (GO) - Biological Process for ZNF337 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF337: view

No data available for SIGNOR curated interactions for ZNF337 Gene

Drugs & Compounds for ZNF337 Gene

No Compound Related Data Available

Transcripts for ZNF337 Gene

Unigene Clusters for ZNF337 Gene

Zinc finger protein 337:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF337 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - -
SP5: - - - - - -
SP6: - - - - - - - - - - -
SP7: -
SP8: - -
SP9: - - - - -

Relevant External Links for ZNF337 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF337 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF337 Gene

Protein differential expression in normal tissues from HIPED for ZNF337 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF337 Gene

Protein tissue co-expression partners for ZNF337 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF337 Gene:


SOURCE GeneReport for Unigene cluster for ZNF337 Gene:


Evidence on tissue expression from TISSUES for ZNF337 Gene

  • Nervous system(4.8)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with ZNF337: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF337 Gene

Orthologs for ZNF337 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF337 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF337 33 34
  • 99.82 (n)
(Bos Taurus)
Mammalia -- 34
  • 40 (a)
Species where no ortholog for ZNF337 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF337 Gene

Gene Tree for ZNF337 (if available)
Gene Tree for ZNF337 (if available)

Paralogs for ZNF337 Gene

Paralogs for ZNF337 Gene

(515) SIMAP similar genes for ZNF337 Gene using alignment to 2 proteins: Pseudogenes for ZNF337 Gene

genes like me logo Genes that share paralogs with ZNF337: view

Variants for ZNF337 Gene

Sequence variations from dbSNP and Humsavar for ZNF337 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000259050 -- 25,688,111(-) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000464402 -- 25,689,201(-) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000505133 -- 25,683,234(-) T/G intron_variant
rs1000506668 -- 25,689,360(-) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000563850 -- 25,683,635(-) T/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF337 Gene

Variant ID Type Subtype PubMed ID
dgv4291n100 CNV gain 25217958
esv3567930 CNV loss 25503493
esv3575367 CNV gain 25503493
esv8845 CNV gain 19470904
nsv522873 CNV gain 19592680

Variation tolerance for ZNF337 Gene

Residual Variation Intolerance Score: 29.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.14; 80.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF337 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF337 Gene

Disorders for ZNF337 Gene

Additional Disease Information for ZNF337

No disorders were found for ZNF337 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF337 Gene

Publications for ZNF337 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  4. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58
  5. System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability. (PMID: 25755297) Xiao Z … Vertegaal AC (Molecular & cellular proteomics : MCP 2015) 4 58

Products for ZNF337 Gene

Sources for ZNF337 Gene

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