Aliases for ZNF335 Gene
Aliases for ZNF335 Gene
External Ids for ZNF335 Gene
- HGNC: 15807
- Entrez Gene: 63925
- Ensembl: ENSG00000198026
- OMIM: 610827
- UniProtKB: Q9H4Z2
Previous GeneCards Identifiers for ZNF335 Gene
- GC20M044305
- GC20M045215
- GC20M045262
- GC20M044010
- GC20M044577
- GC20M041318
Summaries for ZNF335 Gene
-
The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008]
GeneCards Summary for ZNF335 Gene
ZNF335 (Zinc Finger Protein 335) is a Protein Coding gene. Diseases associated with ZNF335 include Microcephaly 10, Primary, Autosomal Recessive and Microcephaly. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Developmental Biology. Gene Ontology (GO) annotations related to this gene include transcription regulatory region DNA binding and RNA polymerase II core promoter sequence-specific DNA binding. An important paralog of this gene is ZFP64.
UniProtKB/Swiss-Prot for ZNF335 Gene
-
Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation.
Additional gene information for ZNF335 Gene
- Monarch Initiative
- Search for ZNF335 at DataMed
- Search for ZNF335 at HumanCyc
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF335 Gene
Genomics for ZNF335 Gene
GeneHancer (GH) Regulatory Elements for ZNF335 Gene
Promoters and enhancers for ZNF335 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around ZNF335 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the ZNF335 gene promoter:
-
- AP-1
- c-Jun
- ATF-2
- NF-kappaB1
- RelA
- CREB
- deltaCREB
- NF-kappaB
- NF-kappaB2
Regulatory Element Products
Genomic Locations for ZNF335 Gene
Genomic Locations for ZNF335 Gene
- chr20:45,948,653-45,972,194
- (GRCh38/hg38)
- Size:
- 23,542 bases
- Orientation:
- Minus strand
- chr20:44,577,292-44,600,833
- (GRCh37/hg19)
- Size:
- 23,542 bases
- Orientation:
- Minus strand
Genomic View for ZNF335 Gene
Genes around ZNF335 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q13.12 by Entrez Gene
- 20q13.12 by HGNC
- 20q13.12 by Ensembl
ZNF335 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for ZNF335 Gene
Proteins for ZNF335 Gene
-
Protein details for ZNF335 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H4Z2-ZN335_HUMAN
- Recommended name:
- Zinc finger protein 335
- Protein Accession:
- Q9H4Z2
- B4DLG7
- Q548D0
- Q9H684
Protein attributes for ZNF335 Gene
- Size:
- 1342 amino acids
- Molecular mass:
- 144893 Da
- Quaternary structure:
-
- Interacts with NCOA6; may enhance ligand-dependent transcriptional activation by nuclear hormone receptors. Interacts with CNOT6. Interacts with CNOT9; the interaction is direct. Interacts with members of histone H3Lys4(H3K4) methyltransferase complexes ASCL2, CXXC1, KMT2A/MLL1, RBBP5, SETD1A and WDR5. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity.
- SequenceCaution:
-
- Sequence=BAB15379.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for ZNF335 Gene
Post-translational modifications for ZNF335 Gene
Other Protein References for ZNF335 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for ZNF335
- Novus Biologicals Antibodies for ZNF335
-
Abcam antibodies for ZNF335
- Invitrogen Antibodies for ZNF335 (AFLGC-ZNF335)
- GeneTex ZNF335 Antibody for ZNF335
-
Boster Bio Antibodies for ZNF335
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for ZNF335
- Origene Custom Protein Services for ZNF335
- Novus Biologicals proteins for ZNF335
- Search GeneTex for Proteins for ZNF335
Assay Products
- antibodies-online: Search results for 8 available ZNF335 Elisa Kits ranked by validation data
- Compare Top ZNF335 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for ZNF335 Gene
Domains & Families for ZNF335 Gene
Gene Families for ZNF335 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for ZNF335 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for ZNF335 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H4Z2- Family:
-
- Belongs to the krueppel C2H2-type zinc-finger protein family.
Function for ZNF335 Gene
Molecular function for ZNF335 Gene
- UniProtKB/Swiss-Prot Function:
- Component or associated component of some histone methyltransferase complexes may regulate transcription through recruitment of those complexes on gene promoters. Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. Plays an important role in neural progenitor cell proliferation and self-renewal through the regulation of specific genes involved brain development, including REST. Also controls the expression of genes involved in somatic development and regulates, for instance, lymphoblast proliferation.
Phenotypes From GWAS Catalog for ZNF335 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding | IBA | -- |
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISM | 19274049 |
| GO:0003676 | nucleic acid binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for ZNF335 Gene
- MGI mutant phenotypes for ZNF335:
- inferred from 7 alleles
- GenomeRNAi human phenotypes for ZNF335:
Animal Models for ZNF335 Gene
- MGI Knock Outs for ZNF335:
-
- Zfp335 Zfp335<tm1.2Caw>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for ZNF335
-
CRISPR Products
-
OriGene CRISPR knockouts for ZNF335
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF335
- genomics-online: gRNA clones - Search results for 37 available ZNF335 gene related products
- Overview of 37 available ZNF335 gene related products
- Applied Biological Materials CRISPR for ZNF335
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF335
- GenScript: Design CRISPR guide RNA sequences for ZNF335
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF335
- Browse OriGene Inhibitory RNA Products For ZNF335
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF335
- genomics-online: shRNA clones - Search results for 37 available ZNF335 gene related products
- Overview of 37 available ZNF335 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ZNF335
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF335
- Applied Biological Materials Clones for ZNF335
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF335 Gene
Localization for ZNF335 Gene
Subcellular locations from UniProtKB/Swiss-Prot for ZNF335 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0035097 | colocalizes_with histone methyltransferase complex | IDA,IEA | 23178126 |
Pathways & Interactions for ZNF335 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
| 2 | Developmental Biology | ||
Pathways by source for ZNF335 Gene
3 Reactome pathways for ZNF335 Gene
Interacting Proteins for ZNF335 Gene
GPS-Prot Interaction Network for ZNF335
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001701 | in utero embryonic development | IEA | -- |
| GO:0002052 | positive regulation of neuroblast proliferation | IEA,ISS | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
No data available for SIGNOR curated interactions for ZNF335 Gene
Transcripts for ZNF335 Gene
mRNA/cDNA for ZNF335 Gene
- (4) REFSEQ mRNAs :
- (7) Additional mRNA sequences :
- (110) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000322927 4430 bps (uc002xqw.4)
- ENST00000475002 1721 bps (uc061xkt.1)
- ENST00000476822 1370 bps (uc061xku.1)
- ENST00000494955 1893 bps (uc002xqy.4)
Unigene Clusters for ZNF335 Gene
- Zinc finger protein 335:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for ZNF335
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for ZNF335
- genomics-online: gRNA clones - Search results for 37 available ZNF335 gene related products
- Overview of 37 available ZNF335 gene related products
- Applied Biological Materials CRISPR for ZNF335
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for ZNF335
- GenScript: Design CRISPR guide RNA sequences for ZNF335
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for ZNF335
- Browse OriGene Inhibitory RNA Products For ZNF335
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF335
- genomics-online: shRNA clones - Search results for 37 available ZNF335 gene related products
- Overview of 37 available ZNF335 gene related products
Clone Products
- Sino Biological Human cDNA Clone for ZNF335
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for ZNF335
- Applied Biological Materials Clones for ZNF335
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | · | 10d | ^ | 11a | · | 11b | ^ |
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| SP21: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP22: |
| ExUns: | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | · | 16d | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21a | · | 21b | · | 21c | · | 21d | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25 | ^ |
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| SP22: |
| ExUns: | 26 | ^ | 27a | · | 27b | ^ | 28 | ^ | 29a | · | 29b |
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Expression for ZNF335 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Intermediate Mesoderm (Gastrulation Derivatives)
This gene is overexpressed in Blymphocyte (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF335 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of ZNF335 Gene:
ZNF335SOURCE GeneReport for Unigene cluster for ZNF335 Gene:
Hs.174193mRNA Expression by UniProt/SwissProt for ZNF335 Gene:
Q9H4Z2-ZN335_HUMAN
Tissue specificity:
Ubiquitously expressed.
Evidence on tissue expression from TISSUES for ZNF335 Gene
- Kidney(4.1)
- Liver(4.1)
- Nervous system(2.4)
Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF335 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cerebellum
- chin
- eye
- face
- forehead
- head
- jaw
- mandible
- maxilla
- mouth
- nose
- pharynx
- skull
Limb:
- ankle
- digit
- elbow
- finger
- foot
- hand
- hip
- knee
- lower limb
- shoulder
- toe
- upper limb
- wrist
General:
- spinal cord
Primer Products
-
OriGene qPCR primer pairs for ZNF335
- genomics-online: primer clones - Search results for 37 available ZNF335 gene related products
- Overview of 37 available ZNF335 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for ZNF335 Gene
Orthologs for ZNF335 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | ZNF335 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | ZNF335 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | ZNF335 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Zfp335 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Zfp335 16 34 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | ZNF335 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | ZNF335 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.27543 33 |
|
||
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.1147 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | LOC100148891 33 |
|
||
| ZNF335 34 |
|
OneToOne |
- Species where no ortholog for ZNF335 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for ZNF335 Gene
- ENSEMBL:
- Gene Tree for ZNF335 (if available)
- TreeFam:
- Gene Tree for ZNF335 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for ZNF335: view image
Paralogs for ZNF335 Gene
Variants for ZNF335 Gene
| SNP ID | Clin | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs117132825 | uncertain-significance, likely-benign, not specified, not provided | 45,960,265(-) | G/A | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs117802609 | likely-benign, not specified, not provided | 45,967,623(-) | C/T | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs145110365 | uncertain-significance, not provided, not specified | 45,967,740(-) | G/A | coding_sequence_variant, missense_variant, non_coding_transcript_variant | |
| rs397514642 | pathogenic, Inborn genetic diseases, Primary autosomal recessive microcephaly 10, Microcephaly 10, primary, autosomal recessive (MCPH10) [MIM:615095] | 45,950,453(-) | C/A/T | coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant | |
| rs749190523 | pathogenic, Primary autosomal recessive microcephaly 10 | 45,949,365(-) | C/A/T | coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant, non_coding_transcript_variant, stop_gained |
Residual Variation Intolerance Score:
2.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.56;
65.04% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for ZNF335 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF335 Gene
Disorders for ZNF335 Gene
(2) MalaCards diseases for ZNF335 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| microcephaly 10, primary, autosomal recessive |
|
|
| microcephaly |
|
|
Search ZNF335 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
ZN335_HUMAN- Microcephaly 10, primary, autosomal recessive (MCPH10) [MIM:615095]: A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH10 is characterized by extremely small head size and death usually by 1 year of age. Neuropathologic examination shows severe loss of neurons as well as neuronal loss of polarity and abnormal dendritic maturation. {ECO:0000269 PubMed:23178126}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for ZNF335
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for ZNF335 Gene
Publications for ZNF335 Gene
- Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation. (PMID: 19131338) Garapaty S … Samuels HH (The Journal of biological chemistry 2009) 2 3 4 22 58
- NRC-interacting factor 1 is a novel cotransducer that interacts with and regulates the activity of the nuclear hormone receptor coactivator NRC. (PMID: 12215545) Mahajan MA … Samuels HH (Molecular and cellular biology 2002) 2 3 4 22 58
- Components of the CCR4-NOT complex function as nuclear hormone receptor coactivators via association with the NRC-interacting Factor NIF-1. (PMID: 18180299) Garapaty S … Samuels HH (The Journal of biological chemistry 2008) 3 4 22 58
- Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation. (PMID: 23178126) Yang YJ … Walsh CA (Cell 2012) 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
Products for ZNF335 Gene
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- GeneTex ZNF335 Antibody for ZNF335
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- genomics-online: cdna clones - Search results for 37 available ZNF335 gene related products
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- Boster Bio Antibodies for ZNF335
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Sources for ZNF335 Gene
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