This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [pr... See more...

Aliases for ZNF334 Gene

Aliases for ZNF334 Gene

  • Zinc Finger Protein 334 2 3 4 5

External Ids for ZNF334 Gene

Previous GeneCards Identifiers for ZNF334 Gene

  • GC20M044858
  • GC20M045682
  • GC20M045729
  • GC20M045263
  • GC20M044563
  • GC20M045129
  • GC20M041870

Summaries for ZNF334 Gene

Entrez Gene Summary for ZNF334 Gene

  • This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for ZNF334 Gene

ZNF334 (Zinc Finger Protein 334) is a Protein Coding gene. Diseases associated with ZNF334 include Rheumatoid Arthritis. Among its related pathways are Gene Expression and Herpes simplex virus 1 infection. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA-binding transcription factor activity. An important paralog of this gene is ZNF33B.

UniProtKB/Swiss-Prot Summary for ZNF334 Gene

Additional gene information for ZNF334 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for ZNF334 Gene

Genomics for ZNF334 Gene

GeneHancer (GH) Regulatory Elements for ZNF334 Gene

Promoters and enhancers for ZNF334 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J046512 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 567.4 +0.3 280 1.8 ZBTB40 NRF1 POLR2G ZBTB11 GABPA ZBTB26 SAP30 KLF7 ZEB1 ZNF341 ZNF334 piR-41306-165
GH20J045967 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 58.7 +542.7 542707 5.8 EP300 FOXK2 ZBTB40 ZNF217 CTCF ZSCAN5C TCF12 SIN3A MYC NRF1 ZNF335 lnc-PCIF1-2 NCOA5 ZNF334 TP53RK SLC35C2 PCIF1 CD40 ZNF663P SYS1
GH20J046255 Enhancer 1 Ensembl ENCODE 50.5 +257.8 257826 0.9 ZNF217 ZNF300 ZNF662 CTBP1 ZNF341 ZNF148 ZNF491 CTCF KLF9 WT1 NCOA5 ZNF334 ZNF663P ZSWIM1 TP53RK SPATA25 ZNF335 ZSWIM3 SLC2A10 ELMO2
GH20J046522 Enhancer 0.8 ENCODE 60.6 -9.7 -9682 1.2 EP300 NCOR1 SKI TEAD1 ZKSCAN8 ZSCAN9 KMT2B FOXA2 CEBPB KAT7 ZNF334 OCSTAMP SLC13A3 SLC2A10 ELMO2 HSALNG0130491
GH20J046088 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 18.7 +424.3 424280 3 HNRNPK ZBTB40 EP300 CTCF ZSCAN5C SIN3A MYC NRF1 POLR2G GTF2E2 NCOA5 CD40 TP53RK PCIF1 ZNF335 SLC35C2 ZNF334 SNX21 ENSG00000271984 SYS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF334 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for ZNF334

Top Transcription factor binding sites by QIAGEN in the ZNF334 gene promoter:
  • AREB6
  • GATA-1
  • GATA-2
  • GATA-3
  • HNF-3beta
  • LCR-F1
  • PPAR-alpha

Genomic Locations for ZNF334 Gene

Genomic Locations for ZNF334 Gene
chr20:46,481,908-46,513,581
(GRCh38/hg38)
Size:
31,674 bases
Orientation:
Minus strand
chr20:45,129,701-45,142,198
(GRCh37/hg19)
Size:
12,498 bases
Orientation:
Minus strand

Genomic View for ZNF334 Gene

Genes around ZNF334 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF334 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF334 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF334 Gene

Proteins for ZNF334 Gene

  • Protein details for ZNF334 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCZ1-ZN334_HUMAN
    Recommended name:
    Zinc finger protein 334
    Protein Accession:
    Q9HCZ1
    Secondary Accessions:
    • Q5T6U2
    • Q9NVW4

    Protein attributes for ZNF334 Gene

    Size:
    680 amino acids
    Molecular mass:
    79649 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZNF334 Gene

Post-translational modifications for ZNF334 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF334 Gene

Domains & Families for ZNF334 Gene

Gene Families for ZNF334 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF334 Gene

Blocks:
  • KRAB box
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ZNF334 Gene

GenScript: Design optimal peptide antigens:
  • Zinc finger protein 334 (Q5XKG8_HUMAN)
  • Zinc finger protein 334 (ZN334_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9HCZ1

UniProtKB/Swiss-Prot:

ZN334_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF334: view

Function for ZNF334 Gene

Molecular function for ZNF334 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF334 Gene

Gene Ontology (GO) - Molecular Function for ZNF334 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF334: view
genes like me logo Genes that share phenotypes with ZNF334: view

Animal Models for ZNF334 Gene

MGI Knock Outs for ZNF334:
  • Zfp334 Zfp334<tm1.1(KOMP)Vlcg>

Animal Model Products

CRISPR Products

miRNA for ZNF334 Gene

miRTarBase miRNAs that target ZNF334

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZNF334 Gene

Localization for ZNF334 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF334 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF334 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF334 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF334: view

Pathways & Interactions for ZNF334 Gene

genes like me logo Genes that share pathways with ZNF334: view

Pathways by source for ZNF334 Gene

2 Reactome pathways for ZNF334 Gene
1 KEGG pathway for ZNF334 Gene

Gene Ontology (GO) - Biological Process for ZNF334 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ZNF334: view

No data available for SIGNOR curated interactions for ZNF334 Gene

Drugs & Compounds for ZNF334 Gene

No Compound Related Data Available

Transcripts for ZNF334 Gene

mRNA/cDNA for ZNF334 Gene

17 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF334 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - -
SP3: - - - - -
SP4: -
SP5: -

Relevant External Links for ZNF334 Gene

GeneLoc Exon Structure for
ZNF334

Expression for ZNF334 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ZNF334 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF334 Gene

This gene is overexpressed in Cervix (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF334 Gene



Protein tissue co-expression partners for ZNF334 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for ZNF334

SOURCE GeneReport for Unigene cluster for ZNF334 Gene:

Hs.147041
genes like me logo Genes that share expression patterns with ZNF334: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF334 Gene

Orthologs for ZNF334 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF334 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF334 31 30
  • 99.71 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC685574 30
  • 75.34 (n)
mouse
(Mus musculus)
Mammalia Zfp334 17 31 30
  • 72.67 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 37 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 36 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 33 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 31
  • 25 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 31
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 38 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii CU207245.2 31
  • 39 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
ManyToMany
-- 31
  • 36 (a)
ManyToMany
-- 31
  • 33 (a)
ManyToMany
-- 31
  • 28 (a)
ManyToMany
Species where no ortholog for ZNF334 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF334 Gene

ENSEMBL:
Gene Tree for ZNF334 (if available)
TreeFam:
Gene Tree for ZNF334 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF334: view image

Paralogs for ZNF334 Gene

Paralogs for ZNF334 Gene

(466) SIMAP similar genes for ZNF334 Gene using alignment to 3 proteins:

  • ZN334_HUMAN
  • M0R3E1_HUMAN
  • Q5XKG8_HUMAN
genes like me logo Genes that share paralogs with ZNF334: view

Variants for ZNF334 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for ZNF334 Gene

SNP ID Clinical significance and condition Chr 20 pos Variation AA Info Type
rs3764690 - p.Asn547Ser

Additional dbSNP identifiers (rs#s) for ZNF334 Gene

Structural Variations from Database of Genomic Variants (DGV) for ZNF334 Gene

Variant ID Type Subtype PubMed ID
esv3645954 CNV loss 21293372
nsv1061899 CNV loss 25217958
nsv833994 CNV gain 17160897

Variation tolerance for ZNF334 Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.71; 46.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF334 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF334

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF334 Gene

Disorders for ZNF334 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ZNF334 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
rheumatoid arthritis
  • ra
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for ZNF334

genes like me logo Genes that share disorders with ZNF334: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ZNF334 Gene

Publications for ZNF334 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 54
  4. The in vitro modulatory effect of TNFα on the mRNA expression and protein levels of zinc finger protein ZNF334 in CD4(+) lymphocytes of healthy people. (PMID: 25738173) Henc I … Witkowski JM (Acta biochimica Polonica 2015) 3 54
  5. Varying expression of four genes sharing a common regulatory sequence may differentiate rheumatoid arthritis from ageing effects on the CD4(+) lymphocytes. (PMID: 20738421) Soroczyńska-Cybula M … Witkowski JM (Immunology 2011) 3 54

Products for ZNF334 Gene

Sources for ZNF334 Gene