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Aliases for ZNF333 Gene

Aliases for ZNF333 Gene

  • Zinc Finger Protein 333 2 3 4 5
  • KIAA1806 4

External Ids for ZNF333 Gene

Previous GeneCards Identifiers for ZNF333 Gene

  • GC19P015169
  • GC19P014646
  • GC19P014800
  • GC19P014367

Summaries for ZNF333 Gene

GeneCards Summary for ZNF333 Gene

ZNF333 (Zinc Finger Protein 333) is a Protein Coding gene. Among its related pathways are Herpes simplex virus 1 infection and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is ZNF17.

UniProtKB/Swiss-Prot for ZNF333 Gene

Additional gene information for ZNF333 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF333 Gene

Genomics for ZNF333 Gene

GeneHancer (GH) Regulatory Elements for ZNF333 Gene

Promoters and enhancers for ZNF333 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J014689 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 615.8 +0.1 114 2.6 ELF3 ZFX NKRF POLR2A ZNF687 ELF1 KLF14 CREM PRDM1 EGR1 ZNF333 ADGRE3 NDUFB7
GH19J013833 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE dbSUPER 53.6 -845.2 -845215 23.1 HDGF MTA3 SP1 ZFX CC2D1A ZNF652 ELF3 ZKSCAN8 MNT CBFA2T2 GC19M013965 ENSG00000267519 CCDC130 ZNF333 MRI1 TRMT1 DCAF15 RFX1 DDX39A RPS6P25
GH19J014378 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 40.9 -307.2 -307211 7.7 SP1 CC2D1A ZFX ZNF148 NKRF MLLT1 ZNF121 GTF2F1 CSDE1 ZNF687 ADGRE5 CCDC130 AKAP8 MRI1 ZNF333 BRD4 DDX39A DCAF15 RFX1 ENSG00000267519
GH19J015376 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 34.3 +689.5 689514 5.5 SP1 ELF3 ZFX SIX5 NKRF POLR2A ZNF121 RERE ZNF687 FOS AKAP8 ENSG00000268189 ZNF333 BRD4 TPM4 DDX39A AKAP8L GC19M015202
GH19J014000 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.7 -685.7 -685687 7 MTA3 ZNF652 SP1 ELF3 CC2D1A ZFX MNT SIX5 CBFA2T2 ZNF148 RFX1 CCDC130 TRMT1 DDX39A DCAF15 MRI1 ZNF333 ENSG00000267519 ZSWIM4 TECR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF333 on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF333 Gene

Genomic Locations for ZNF333 Gene
chr19:14,689,787-14,733,746
(GRCh38/hg38)
Size:
43,960 bases
Orientation:
Plus strand
chr19:14,800,613-14,844,558
(GRCh37/hg19)
Size:
43,946 bases
Orientation:
Plus strand

Genomic View for ZNF333 Gene

Genes around ZNF333 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF333 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF333 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF333 Gene

Proteins for ZNF333 Gene

  • Protein details for ZNF333 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JL9-ZN333_HUMAN
    Recommended name:
    Zinc finger protein 333
    Protein Accession:
    Q96JL9
    Secondary Accessions:
    • Q6P2E6
    • Q86WS6
    • Q8TDL0

    Protein attributes for ZNF333 Gene

    Size:
    665 amino acids
    Molecular mass:
    75544 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF333 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF333 Gene

Post-translational modifications for ZNF333 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF333 Gene

Domains & Families for ZNF333 Gene

Gene Families for ZNF333 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Transcription factors

Protein Domains for ZNF333 Gene

Suggested Antigen Peptide Sequences for ZNF333 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ36709 fis, clone UTERU2009951, highly similar to Zinc finger protein 333 (B3KSN8_HUMAN)
  • cDNA FLJ78332, highly similar to Homo sapiens zinc finger protein 333, mRNA (Q6P2E6_HUMAN)
  • ZNF333 protein (Q86WS6_HUMAN)
  • Zinc finger protein 333 (ZN333_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96JL9

UniProtKB/Swiss-Prot:

ZN333_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF333: view

Function for ZNF333 Gene

Molecular function for ZNF333 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.

Phenotypes From GWAS Catalog for ZNF333 Gene

Gene Ontology (GO) - Molecular Function for ZNF333 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF333: view
genes like me logo Genes that share phenotypes with ZNF333: view

Animal Model Products

CRISPR Products

miRNA for ZNF333 Gene

miRTarBase miRNAs that target ZNF333

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF333 - Now 50% OFF >
  • * ZNF333 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF333 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF333 Gene

Localization for ZNF333 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF333 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF333 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF333 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with ZNF333: view

Pathways & Interactions for ZNF333 Gene

genes like me logo Genes that share pathways with ZNF333: view

Pathways by source for ZNF333 Gene

2 Reactome pathways for ZNF333 Gene
1 KEGG pathway for ZNF333 Gene

Gene Ontology (GO) - Biological Process for ZNF333 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF333: view

No data available for SIGNOR curated interactions for ZNF333 Gene

Drugs & Compounds for ZNF333 Gene

No Compound Related Data Available

Transcripts for ZNF333 Gene

Unigene Clusters for ZNF333 Gene

Zinc finger protein 333:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for ZNF333 - Now 50% OFF >
  • * ZNF333 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * ZNF333 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF333 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15
SP1: - - - - - -
SP2: - -
SP3: - -
SP4:
SP5:

Relevant External Links for ZNF333 Gene

GeneLoc Exon Structure for
ZNF333
ECgene alternative splicing isoforms for
ZNF333

Expression for ZNF333 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF333 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF333 Gene



NURSA nuclear receptor signaling pathways regulating expression of ZNF333 Gene:

ZNF333

SOURCE GeneReport for Unigene cluster for ZNF333 Gene:

Hs.515215

mRNA Expression by UniProt/SwissProt for ZNF333 Gene:

Q96JL9-ZN333_HUMAN
Tissue specificity: Highly expressed in heart.

Evidence on tissue expression from TISSUES for ZNF333 Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with ZNF333: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF333 Gene

Orthologs for ZNF333 Gene

This gene was present in the common ancestor of animals.

Orthologs for ZNF333 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF333 35 34
  • 99 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF333 35 34
  • 81.86 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF333 35 34
  • 76.14 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 46 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
-- 35
  • 39 (a)
ManyToMany
-- 35
  • 35 (a)
ManyToMany
-- 35
  • 32 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm14444 35
  • 32 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 28 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ZNF557 35
  • 22 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Kr 36
  • 48 (a)
CG6254 36
  • 38 (a)
CG10366 36
  • 34 (a)
CG17568 36
  • 34 (a)
Species where no ortholog for ZNF333 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF333 Gene

ENSEMBL:
Gene Tree for ZNF333 (if available)
TreeFam:
Gene Tree for ZNF333 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF333: view image

Paralogs for ZNF333 Gene

(498) SIMAP similar genes for ZNF333 Gene using alignment to 8 proteins:

  • ZN333_HUMAN
  • B3KSN8_HUMAN
  • F5H0A3_HUMAN
  • M0R0S8_HUMAN
  • M0R113_HUMAN
  • M0R1P1_HUMAN
  • Q6P2E6_HUMAN
  • Q86WS6_HUMAN
genes like me logo Genes that share paralogs with ZNF333: view

Variants for ZNF333 Gene

Sequence variations from dbSNP and Humsavar for ZNF333 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000129148 -- 14,706,871(+) CTGCAGGCACTGCCGTGGC/C genic_upstream_transcript_variant, intron_variant
rs1000297069 -- 14,714,250(+) G/A intron_variant
rs1000373204 -- 14,708,306(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000446831 -- 14,690,041(+) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000560575 -- 14,690,233(+) T/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF333 Gene

Variant ID Type Subtype PubMed ID
esv3893167 CNV gain 25118596
nsv1060306 CNV loss 25217958
nsv1072329 CNV deletion 25765185
nsv1126515 CNV deletion 24896259
nsv458357 CNV loss 19166990
nsv578680 CNV loss 21841781

Variation tolerance for ZNF333 Gene

Residual Variation Intolerance Score: 97.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.43; 92.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF333 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF333

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF333 Gene

Disorders for ZNF333 Gene

Additional Disease Information for ZNF333

No disorders were found for ZNF333 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF333 Gene

Publications for ZNF333 Gene

  1. Characterization of ZNF333, a novel double KRAB domain containing zinc finger gene on human chromosome 19p13.1. (PMID: 12151103) Tian Y … Lo WH (Biochimica et biophysica acta 2002) 2 3 4 58
  2. Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin. (PMID: 17607528) Oh Y … Fung LW (Cellular & molecular biology letters 2007) 3 23 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Identification of the DNA binding element of the human ZNF333 protein. (PMID: 15607024) Jing Z … Huang S (Journal of biochemistry and molecular biology 2004) 3 23 58
  5. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 58

Products for ZNF333 Gene

Sources for ZNF333 Gene

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